Summary: HSCB C-terminal oligomerisation domain
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HSCB C-terminal oligomerisation domain Provide feedback
This domain is the HSCB C-terminal oligomerisation domain and is found on co-chaperone proteins.
Internal database links
|SCOOP:||Mvb12 DUF2533 SAC3 VPS11_C MTBP_N|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR009073
This entry represents the C-terminal oligomerisation domain found in HscB (heat shock cognate protein B), which is also known as HSC20 (20K heat shock cognate protein). HscB acts as a co-chaperone to regulate the ATPase activity and peptide-binding specificity of the molecular chaperone HscA, also known as HSC66 (HSP70 class). HscB proteins contain two domains, an N-terminal J-domain, which is involved in interactions with HscA, connected by a short loop to the C-terminal oligomerisation domain; the two domains make contact through a hydrophobic interface. The core of the oligomerisation domain is thought to bind and target proteins to HscA and consists of an open, three-helical bundle [PUBMED:11124030]. HscB, along with HscA, has been shown to play a role in the biogenesis of iron-sulphur proteins.
|Biological process||protein oligomerization (GO:0051259)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Pfam-B_6234 (release 14.0)|
|Author:||Bateman A, Finn RD|
|Number in seed:||345|
|Number in full:||6140|
|Average length of the domain:||75.40 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||41.88 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HSCB_C domain has been found. There are 13 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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