Summary: LETM1-like protein
LETM1-like protein Provide feedback
Members of this family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange . Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans .
Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A; , Genomics 1999;60:218-225.: LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients. PUBMED:10486213 EPMC:10486213
Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, Barsanti P; , Mol Gen Genet 1999;261:64-70.: Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. PUBMED:10071211 EPMC:10071211
Froschauer E, Nowikovsky K, Schweyen RJ; , Biochim Biophys Acta 2005;1711:41-48.: Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. PUBMED:15904662 EPMC:15904662
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR011685This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site [PUBMED:10486213], are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [PUBMED:10486213]. A member of this family, SWISSPROT, is known to be expressed in the mitochondria of Drosophila melanogaster [PUBMED:10071211], suggesting that this may be a group of mitochondrial proteins.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_2202 (release 14.0)|
|Author:||Fenech M, Wood V, Mistry J|
|Number in seed:||156|
|Number in full:||1461|
|Average length of the domain:||212.00 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||42.52 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the LETM1 domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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