Summary: G-box binding protein MFMR
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G-box binding protein MFMR Provide feedback
This region is found to the N-terminus of the PF00170 transcription factor domain. It is between 150 and 200 amino acids in length. The N-terminal half is rather rich in proline residues and has been termed the PRD (proline rich domain) [2] whereas the C-terminal half is more polar and has been called the MFMR (multifunctional mosaic region). It has been suggested that this family is composed of three sub-families called A, B and C [1] classified according to motif composition. It has been suggested that some of these motifs may be involved in mediating protein-protein interactions [1]. The MFMR region contains a nuclear localisation signal in bZIP opaque and GBF-2 [2]. The MFMR also contains a transregulatory activity in TAF-1. The MFMR in CPRF-2 contains cytoplasmic retention signals [2].
Literature references
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Meier I, Gruissem W; , Nucleic Acids Res 1994;22:470-478.: Novel conserved sequence motifs in plant G-box binding proteins and implications for interactive domains. PUBMED:8127687 EPMC:8127687
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Siberil Y, Doireau P, Gantet P; , Eur J Biochem 2001;268:5655-5666.: Plant bZIP G-box binding factors. Modular structure and activation mechanisms. PUBMED:11722549 EPMC:11722549
This tab holds annotation information from the InterPro database.
InterPro entry IPR012900
This region is often found to the N terminus of the basic-leucine zipper domain (INTERPRO). It is between 150 and 200 amino acids in length. The N-terminal half of this domain is rich in proline residues and has been termed the PRD (proline rich domain) [PUBMED:11722549], whereas the C-terminal half is more polar and has been called the MFMR (multifunctional mosaic region). According to their motif composition, proteins containing this domain can be classified into three sub-families called A, B and C [PUBMED:8127687]. It has been suggested that some of these motifs may be involved in mediating protein-protein interactions [PUBMED:8127687]. The MFMR region contains a nuclear localisation signal in bZIP opaque and GBF-2 [PUBMED:11722549]. The MFMR also contains a transregulatory activity in TAF-1. The MFMR in CPRF-2 contains cytoplasmic retention signals [PUBMED:11722549].
Domain organisation
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Alignments
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (39) |
Full (911) |
Representative proteomes | UniProt (1267) |
NCBI (1983) |
Meta (0) |
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RP15 (27) |
RP35 (497) |
RP55 (729) |
RP75 (897) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
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Seed (39) |
Full (911) |
Representative proteomes | UniProt (1267) |
NCBI (1983) |
Meta (0) |
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RP15 (27) |
RP35 (497) |
RP55 (729) |
RP75 (897) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
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Curation
Seed source: | Pfam-B_5000 (release 14.0) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Fenech M |
Number in seed: | 39 |
Number in full: | 911 |
Average length of the domain: | 90.80 aa |
Average identity of full alignment: | 48 % |
Average coverage of the sequence by the domain: | 25.04 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 97 | ||||||||||||
Family (HMM) version: | 12 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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