Summary: MBA1-like protein
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Mba1 is an inner membrane protein that is part of the mitochondrial protein export machinery . It binds to the large subunit of mitochondrial ribosomes and cooperates with the C-terminal ribosome-binding domain of Oxa1, which is a central component of the insertion machinery of the inner membrane. In the absence of both Mba1 and the C-terminus of Oxa1, mitochondrial translation products fail to be properly inserted into the inner membrane and serve as substrates of the matrix chaperone Hsp70 . It is proposed that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosome exit site to the insertion machinery of the inner membrane .
Preuss M, Leonhard K, Hell K, Stuart RA, Neupert W, Herrmann JM; , J Cell Biol 2001;153:1085-1096.: Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae. PUBMED:11381092 EPMC:11381092
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024621
Mba1 is an inner membrane protein that is part of the mitochondrial protein export machinery [PUBMED:8690083, PUBMED:11381092]. It binds to the large subunit of mitochondrial ribosomes and cooperates with the C-terminal ribosome-binding domain of Oxa1, which is a central component of the insertion machinery of the inner membrane. In the absence of both Mba1 and the C terminus of Oxa1, mitochondrial translation products fail to be properly inserted into the inner membrane and serve as substrates of the matrix chaperone Hsp70 [PUBMED:16601683]. It is proposed that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosome exit site to the insertion machinery of the inner membrane [PUBMED:16601683].
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This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.
The clan contains the following 24 members:CaMKII_AD DUF1348 DUF2358 DUF3225 DUF3804 DUF4440 DUF4467 LEH Lumazine_bd Lumazine_bd_2 MBA1 MecA_N Mtr2 NTF2 PHZA_PHZB Ring_hydroxyl_B Scytalone_dh SnoaL SnoaL_2 SnoaL_3 SnoaL_4 Tim44 VirB8 WI12
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Curation and family details
|Seed source:||Groocock L|
|Author:||Groocock L, Finn RD|
|Number in seed:||7|
|Number in full:||74|
|Average length of the domain:||223.40 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||77.91 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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