Summary: Prokaryotic membrane lipoprotein lipid attachment site
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Prokaryotic membrane lipoprotein lipid attachment site Provide feedback
In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached .
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012640
In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognises a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached [PUBMED:2202727,PUBMED:3253732].This lipid attachment site is found in homologues of the VirB proteins of type IV secretion systems (T4SS). Conjugal transfer across the cell envelope of Gram-negative bacteria is mediated by a supramolecular structure termed mating pair formation (Mpf) complex. Collectively, secretion pathways ancestrally related to bacterial conjugation systems are now known as T4SS. T4SS are involved in the delivery of effector molecules to eukaryotic target cells; each of these systems exports distinct DNA or protein substrates to effect a myriad of changes in host cell physiology during infection [PUBMED:11309113].
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Superfamily consists of those protein families wherein the lipo-protein attachmnet motif, usually at the N-terminus, is found. regions of sequence downstream of this motif may not be conserved between families in the clan.
The clan contains the following 3 members:Lambda_Bor LPAM_1 MLTD_N
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Short protein clustering|
|Author:||Lee SC, Bateman A|
|Number in seed:||14|
|Number in full:||4523|
|Average length of the domain:||25.00 aa|
|Average identity of full alignment:||59 %|
|Average coverage of the sequence by the domain:||12.27 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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