Summary: Yeast RNA polymerase I subunit RPA14
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Yeast RNA polymerase I subunit RPA14 Provide feedback
This is a family of yeast proteins. A14 is one of the final two subunits of Saccharomyces cerevisiae RNA polymerase I and is proposed to play a role in the recruitment of pol I to the promoter .
Imazawa Y, Hisatake K, Mitsuzawa H, Matsumoto M, Tsukui T, Nakagawa K, Nakadai T, Shimada M, Ishihama A, Nogi Y; , J Biol Chem 2005; [Epub ahead of print]: The fission yeast protein, Ker1p, is an ortholog of RNA polymerase I subunit A14 in saccharomyces cerevisiae, and is required for stable association of Rrn3p and RPA21 in Pol I. PUBMED:15647272 EPMC:15647272
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013239
Saccharomyces cerevisiae RNA polymerase I (Pol I) is a complex consisting of 14 subunits. Subunit RPA14 forms part of a Pol I subcomplex consisting of RPA14 and and RPA43. The RPA14 and RPA43 heterodimer is proposed to play a role in the recruitment of Pol I to the promoter [PUBMED:15647272].
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||17|
|Number in full:||47|
|Average length of the domain:||79.80 aa|
|Average identity of full alignment:||43 %|
|Average coverage of the sequence by the domain:||51.19 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the RNA_polI_A14 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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