Summary: Chromosome segregation protein Spc25
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Chromosome segregation protein Spc25 Provide feedback
This is a family of chromosome segregation proteins. It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex  and in vertebrates it forms part of the Ndc80 complex .
Asakawa H, Hayashi A, Haraguchi T, Hiraoka Y; , Mol Biol Cell 2005; [Epub ahead of print]: Dissociation of the Nuf2-Ndc80 Complex Releases Centromeres from the Spindle-Pole Body during Meiotic Prophase in Fission Yeast. PUBMED:15728720 EPMC:15728720
McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT; , Curr Biol 2004;14:131-137.: The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. PUBMED:14738735 EPMC:14738735
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013255
This is a family of chromosome segregation proteins. It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex [PUBMED:15728720], and in vertebrates it forms part of the Ndc80 complex [PUBMED:14738735].
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Curation and family details
|Seed source:||Pfam-B_14484 (release 16.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||148|
|Number in full:||514|
|Average length of the domain:||70.60 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||27.23 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Spindle_Spc25 domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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