Summary: LNS2 (Lipin/Ned1/Smp2)
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This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins . SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration  and has been identified as a Mg2+-dependent phosphatidate phosphatase ( EC:220.127.116.11) that contains a haloacid dehalogenase (HAD)-like domain . Lipin proteins are involved in adipose tissue development and insulin resistance .
Irie K, Takase M, Araki H, Oshima Y; , Mol Gen Genet 1993;236:283-288.: A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein. PUBMED:8437575 EPMC:8437575
Tange Y, Hirata A, Niwa O; , J Cell Sci 2002;115:4375-4385.: An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin. PUBMED:12376568 EPMC:12376568
Huffman TA, Mothe-Satney I, Lawrence JC Jr; , Proc Natl Acad Sci U S A 2002;99:1047-1052.: Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. PUBMED:11792863 EPMC:11792863
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013209
This domain is found in Saccharomyces cerevisiae (Baker's yeast) protein SMP2, proteins with an N-terminal lipin domain (INTERPRO) and phosphatidylinositol transfer proteins [PUBMED:8437575]. SMP2 is involved in plasmid maintenance and respiration [PUBMED:12376568]. Lipin proteins are involved in adipose tissue development and insulin resistance [PUBMED:11792863].
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This clan represents the haloacid dehalogenase (HAD) superfamily that includes a diverse range of enzymes that use an asp carboxylate as a nucleophile .
The clan contains the following 21 members:5_nucleotid Acid_phosphat_B Acid_PPase DUF705 HAD HAD_2 Hydrolase Hydrolase_3 Hydrolase_6 Hydrolase_like Hydrolase_like2 LNS2 NIF NT5C PGP_phosphatase PMM PNK3P Put_Phosphatase S6PP Trehalose_PPase UMPH-1
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Curation and family details
|Seed source:||Pfam-B_2646 (release 16.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||16|
|Number in full:||814|
|Average length of the domain:||147.40 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||17.04 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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