Summary: MAATS-type transcriptional repressor, C-terminal region
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MAATS-type transcriptional repressor, C-terminal region Provide feedback
This family is named after the various transcriptional regulatory proteins that it contains, including MtrR (Q6RV06), AcrR (P34000), ArpR (Q9KJC4), TtgR (Q9AIU0) and SmeT (Q8KLP4). These are members of the TetR family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [1,2,3].
Kieboom J, de Bont J; , Microbiology 2001;147:43-51.: Identification and molecular characterization of an efflux system involved in Pseudomonas putida S12 multidrug resistance. PUBMED:11160799 EPMC:11160799
Sanchez P, Alonso A, Martinez JL; , Antimicrob Agents Chemother 2002;46:3386-3393.: Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF. PUBMED:12384340 EPMC:12384340
Internal database links
|Similarity to PfamA using HHSearch:||TetR_C_6|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013572
This entry is named after the various transcriptional regulatory proteins that it contains, including MtrR (SWISSPROT), AcrR (SWISSPROT), ArpR (SWISSPROT), TtgR (SWISSPROT) and SmeT (SWISSPROT). These are members of the TetR (tetracycline resistance) family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [PUBMED:1720861, PUBMED:11160799, PUBMED:12384340].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||DNA binding (GO:0003677)|
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This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].
The clan contains the following 9 members:DUF1956 TetR_C TetR_C_2 TetR_C_3 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_9
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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Curation and family details
|Seed source:||Pfam-B_3020 (release 18.0)|
|Number in seed:||12|
|Number in full:||1463|
|Average length of the domain:||119.10 aa|
|Average identity of full alignment:||37 %|
|Average coverage of the sequence by the domain:||55.81 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TetR_C_2 domain has been found. There are 24 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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