Summary: Transcription factor regulating root and shoot growth via Pin3
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Transcription factor regulating root and shoot growth via Pin3 Provide feedback
The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2]. BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway. BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot . The family features a short region of alpha-helix, approximately 60 residues in length, which is found repeated up to three times . BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action .
Mouchel CF, Briggs GC, Hardtke CS;, Genes Dev. 2004;18:700-714.: Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell proliferation and elongation in the root. PUBMED:15031265 EPMC:15031265
Briggs GC, Mouchel CF, Hardtke CS;, Plant Physiol. 2006;140:1306-1316.: Characterization of the plant-specific BREVIS RADIX gene family reveals limited genetic redundancy despite high sequence conservation. PUBMED:16514016 EPMC:16514016
Scacchi E, Salinas P, Gujas B, Santuari L, Krogan N, Ragni L, Berleth T, Hardtke CS;, Proc Natl Acad Sci U S A. 2010;107:22734-22739.: Spatio-temporal sequence of cross-regulatory events in root meristem growth. PUBMED:21149702 EPMC:21149702
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013591
This is a short domain, approximately 35 residues in length that is found near the C terminus in a number of plant proteins, being repeated in some members.
It is found in Brevis radix-like proteins. These may act as a regulator of cell proliferation and elongation in the root [PUBMED:16514016]. It is also found in proteins annotated as involved in disease resistance and in the regulation of chromosome condensation, which also contain other domains with varied functions, such as TIR (INTERPRO) and FYVE (INTERPRO) respectively.
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Curation and family details
|Seed source:||Pfam-B_2116 (release 18.0)|
|Author:||Fenech M, Coggill P|
|Number in seed:||65|
|Number in full:||771|
|Average length of the domain:||54.10 aa|
|Average identity of full alignment:||53 %|
|Average coverage of the sequence by the domain:||9.86 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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