Summary: Archaeal TRASH domain
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Archaeal TRASH domain Provide feedback
This region is found in the C-terminus of a number of archaeal transcriptional regulators. It is thought to function as a metal-sensing regulatory module .
Ettema TJ, Huynen MA, de Vos WM, van der Oost J; , Trends Biochem Sci 2003;28:170-173.: TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance. PUBMED:12713899 EPMC:12713899
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TRASH-like domains contain well-conserved cysteine residues that are thought to be involved in metal coordination. These domains are thus expected to be involved in metal trafficking and heavy-metal resistance. It has been suggested that the members adopt a 'treble-clef' fold, with 3/4 beta strands preceding a C-terminal alpha helix .
The clan contains the following 11 members:Arc_trans_TRASH ATPase-cat_bd DUF2256 DUF329 DUF581 Ribosomal_L24e YHS zf-FCS zf-HIT zf-Mss51 zf-MYND
We make a range of alignments for each Pfam-A family:
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- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_18882 (release 17.0)|
|Author:||Fenech M, |
|Number in seed:||8|
|Number in full:||65|
|Average length of the domain:||36.70 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||22.76 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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