Summary: 7tm Chemosensory receptor
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7tm Chemosensory receptor Provide feedback
This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [1,2].
Robertson HM, Warr CG, Carlson JR; , Proc Natl Acad Sci U S A 2003;100:14537-14542.: Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. PUBMED:14608037 EPMC:14608037
Hill CA, Fox AN, Pitts RJ, Kent LB, Tan PL, Chrystal MA, Cravchik A, Collins FH, Robertson HM, Zwiebel LJ; , Science 2002;298:176-178.: G protein-coupled receptors in Anopheles gambiae. PUBMED:12364795 EPMC:12364795
Internal database links
|SCOOP:||DUF2530 DUF3328 Lant_dehydr_C UBN_AB Adipogenin Abhydrolase_9_N TMEM100|
|Similarity to PfamA using HHSearch:||7tm_6 Trehalose_recp|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013604
This family includes a number of gustatory and odorant receptors mainly from insect species such as Anopheles gambiae (African malaria mosquito) and Drosophila melanogaster (Fruit fly). They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [PUBMED:14608037, PUBMED:12364795].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral component of membrane (GO:0016021)|
|Biological process||sensory perception of taste (GO:0050909)|
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The members of this clan are families of various gustatory and odorant receptors. They are described as being seven-transmembrane receptors, and in fact all show characteristic regions of hydrophobicity on the alignment.
The clan contains the following 4 members:7tm_6 7tm_7 DUF267 Trehalose_recp
We make a range of alignments for each Pfam-A family:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Curation and family details
|Seed source:||Robertson H|
|Author:||Robertson H, Finn R, Fenech M|
|Number in seed:||76|
|Number in full:||1907|
|Average length of the domain:||316.90 aa|
|Average identity of full alignment:||11 %|
|Average coverage of the sequence by the domain:||89.24 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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