Summary: Rib/alpha-like repeat
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Rib/alpha-like repeat Provide feedback
The region featured in this family is found repeated in a number of bacterial surface proteins, such as Rib (P72362) and alpha (Q02192). These are expressed by group B streptococci, and Rib is thought to confer protective immunity.
Wastfelt M, Stalhammar-Carlemalm M, Delisse AM, Cabezon T, Lindahl G; , J Biol Chem 1996;271:18892-18897.: Identification of a family of streptococcal surface proteins with extremely repetitive structure. PUBMED:8702550 EPMC:8702550
Internal database links
|SCOOP:||APS-reductase_C TORC_M PepSY_2 DUF4520 DUF4881|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR012706
This entry represents a region of about 79 amino acids found tandemly repeated up to fourteen times within the proteins that contain it. The repeats lack cysteines and are highly conserved, even at the DNA level, within and between proteins [PUBMED:8702550]. Proteins containing these repeats include the Rib and alpha surface antigens of group B Streptococcus, Esp of Enterococcus faecalis (Streptococcus faecalis), and related proteins of Lactobacillus. Most members of this protein family also have the cell wall anchor motif, LPXTG, shared by many staphyloccal and streptococcal surface antigens. These repeats are thought to define protective epitopes and may play a role in generating phenotypic and genotypic variation [PUBMED:1438195].
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This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.
The clan contains the following 76 members:A2M_N Alpha_adaptinC2 Arch_flagellin Big_1 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 BiPBP_C BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_pro CARDB CBM39 CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N CHU_C Coatamer_beta_C COP-gamma_platf CopC DUF11 DUF2271 DUF3244 DUF4165 DUF4625 DUF5011 DUF916 EpoR_lig-bind Filamin FixG_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 Fn3_assoc He_PIG HYR IFNGR1 IL17R_fnIII_D2 IL6Ra-bind Integrin_alpha2 Interfer-bind Invasin_D3 LEA_2 MG1 Mo-co_dimer Neurexophilin NPCBM_assoc PhoD_N PKD PKD_2 PKD_3 Pur_ac_phosph_N Qn_am_d_aIII REJ RHD_dimer Rib SoxZ SprB SWM_repeat T2SS-T3SS_pil_N TIG Tissue_fac Transglut_C TRAP_beta Y_Y_Y
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_3139 (release 18.0)|
|Number in seed:||10|
|Number in full:||3619|
|Average length of the domain:||65.00 aa|
|Average identity of full alignment:||36 %|
|Average coverage of the sequence by the domain:||19.32 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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