# STOCKHOLM 1.0
#=GF ID Forkhead_N
#=GF AC PF08430.13
#=GF DE Forkhead N-terminal region
#=GF AU Fenech M;0000-0001-7933-4617
#=GF GA 21.6 21.6
#=GF NC 21.4 21.5
#=GF TC 21.6 21.6
#=GF PI Fork_head_N;
#=GF SE Pfam-B_3191 (release 18.0)
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 8817449
#=GF RT Five years on the wings of fork head. 
#=GF RA Kaufmann E, Knochel W; 
#=GF RL Mech Dev 1996;57:3-20.
#=GF DR INTERPRO; IPR013638;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The region described in this family is found towards the
#=GF CC N-terminus of various eukaryotic forkhead/HNF-3-related
#=GF CC transcription factors (which contain the Pfam:PF00250 domain).
#=GF CC These proteins play key roles in embryogenesis, maintenance of
#=GF CC differentiated cell states, and tumourigenesis [1].
#=GF SQ 56
P55317.2/17-169     SYYADTQEAYSSVPvSnmn.................sglGSMNS.MNTYMTMNTM....TTSGNm..............tpASFNM-SYANPGLGAGLSP..GAVAGMPGGSAGAMNSM.........TAAGVTAMGT.ALSPSG-MGA.MGAQQA.AS--MNGLGPY.aAAMNPCMSpm..ayaPSNLGRSRaggggDAKTFKRSYPHA
P23512.1/17-169     SYYADTQEAYSSVPvSnmn.................sglGSMNS.MNTYMTMNTM....TTSGNm..............tpASFNM-SYANPGLGAGLSP..GAVAGMPGGSAGAMNSM.........TAAGVTAMGA.ALSPGG-MGS.MGAQPA.AS--MNGLGPY.aAAMNPCMSpm..ayaPSNLGRSRaggggDAKTFKRSYPHA
P35582.2/17-169     SYYADTQEAYSSVPvSnmn.................sglGSMNS.MNTYMTMNTM....TTSGNm..............tpASFNM-SYANTGLGAGLSP..GAVAGMPGASAGAMNSM.........TAAGVTAMGT.ALSPGG-MGS.MGAQPA.TS--MNGLGPY.aAAMNPCMSpm..ayaPSNLGRSRaggggDAKTFKRSYPHA
Q6P0C9.1/17-156     SYYNDAQEVYSPMT.Nssm................npglSSMNN.MNSYMGMSTS...gN--MT................sSSFNM-SYANPALGAGLSP..GTMAGMPTGG--AMNGM.........G-GGVSSMGT.ALSPSN-LNA.MTAQ-H.SS--MNALNPY..TSMSPTMSsm..tyaQPNLNRAR.....DNKTFRRSYPHA
A0A1D5NX62.1/17-150 NYYGEP-ESYSSVS.Nmn...................agLGMNS.MNTYMTMSAM....STTANmt.............aaTSMNM-SYAN----TGMSP..-SLAGMSPGA-GAMAGM.........GSAGVAGMGA.HLSPS--MSP.MGGQ-A.GS--MNALAPY..TNMNSMSPi....ygQSNLNRSR.....DPKTYRRSYTHA
A0A3M0K4N6.1/24-157 -YYGEP-EGYSSVS.Nmn...................agLGMNS.MNTYMTMSAM....SSTANmt............aaaTSMNM-SYAN----TGMSP..-SLTGMSPGA-GAMSAM.........GSAGVPGMGA.HLSPS--MSP.MGGQ-A.GS--MNALAPY..SNMNSMSPi....ygQSNLNRSR.....DPKTYRRSYTHA
A0A3M0JPD2.1/11-155 SYYADTQEAYSSVPvSnmn.................sglGSMNT.MNTYMTMNTM....TTSGNm..............tsSSFNM-SYANTGLGAGLSP..GAVAGMPAGSAGPVNGM.........P-AGVAAMGT.ALSPGG-INA.MSAQPA.P---MNGLSPY..GGMNPCMSpm..aytQSNLGRTR.....DAKSFKRTYPHA
A0A1D5PCB1.1/17-161 SYYADTQEAYSSVPvSnmn.................sglGSMNT.MNTYMSMNTM....TTSGNm..............tsGSFNM-SYANTGLGAGLSP..GAVAAMPAGSAGAVNGM.........-AAGVAAMGA.ALSPGG-LSA.MSGQPA.A---MNGLGPY..GGMNPCVSpm..aysQSNLGRTR.....DAKSFKRSYPHA
Q9Y261.1/17-158     SYYAEP-EGYSSVS.Nmn...................agLGMNG.MNTYMSMSAAa.mgS---Gsgn...........msaGSMNMSSYVG----AGMSP..-SLAGMSPGAGAMA-GMgg.....saGAAGVAGMGP.HLSPS--LSP.LGGQAA.GA--MGGLAPY..ANMNSMSPm....ygQAGLSRAR.....DPKTYRRSYTHA
P35583.2/17-158     SYYAEP-EGYSSVS.Nmn...................agLGMNG.MNTYMSMSAAa.mgG---Gsgn...........msaGSMNMSSYVG----AGMSP..-SLAGMSPGAGAMAGMSg......saGAAGVAGMGP.HLSPS--LSP.LGGQAA.GA--MGGLAPY..ANMNSMSPm....ygQAGLSRAR.....DPKTYRRSYTHA
M7B113.1/4-128      --------------.G......................lGSMNT.MNTYMTMNTM....TTSGNm..............tsGSFNM-SYANTGLGAGLSP..GTMAGMSAGPTGAMNSM.........T-AGVTAMGT.ALTPTS-MNA.MSAQ-Q.AS--MNGLSPY..AGMNPCMSpm..ayaQSNLTRTR.....DTKSFKRSYPHA
P32182.1/17-158     SYYAEP-EGYSSVS.Nmn...................asLGMNG.MNTYMSMSAAa.mgS---Gsgn...........msaGSMNMSSYVG----AGMSP..-SLAGMSPGAGAMAGMSg......saGAAGVAGMGP.HLSPS--LSP.LGGQAA.GA--MGGLAPY..ANMNSMSPm....ygQAGLSRAR.....DPKTYRRSYTHA
P14734.1/102-209    --------------.-.......................-----.--SMSASMSA....SMSAS.................MNASMNGSMGAAAMNSMGG..NCMTPSSMSYASMGSPLgn.....mgGCMAMSAASMsAAGLSGTYGA.---MPP.GSREMETGSPN.sLGRSRVDK.......--------.....-PTTYRRSYTHA
Q07342.1/19-150     -YYGEP-ECYTSVS.Nmn...................tgLGMNS.MNTYMTMSGM....SSTANmt.............aaNTMNM-SYVN----TGMSP..-SMTGMSPGT-GAMAGM.........G-AGMTGMSA.ALS--PTMSP.MAAQAP.SM---NALTSY..SNMNAMSPm....ygQSNINRSR.....DPKTYRRSYTHA
Q1LV18.1/18-142     -FYSEANEMYSSPSaM.......................NSVSS.LNSYINLNSA....-CSTS.................-SMNM-GYPS----AGLNS..SPLSSMGGGP-------.........NHMSLSPVGS.SLNPSS-LTQ.LGSSAS.---TLGPLSHY..QSMGQPMSqis.ypsPTSLNRTK....eMPKPYRRSLTHA
A0A401PJN5.1/64-194 SYYGES-EGYPTVSnMn....................pgIGMNG.MNTYMTMSAM....GTTANm..............taGSMNM-SYVG----TGMNP..-AMTGMSPGAGSM-NGM.........G-AGMTAMGN.ALSPS--MSP.MSAQAT.S---MNALTSYsnMSMSPMYG.......QSNLNRSR.....DPKTYRRSYTHA
D6WMG3.1/6-139      -LYSDSTTMATSSNaMspm.................tptYSMNS.MSCVSMPSMNc.spQAASF.................GSSMLNSGMP--GGMAMNG..NGMTSSSMGYTTIGSPI.........SNMNAACMAT.PMATMNSYGS.VGTLGR.GDLGGGDTSPN..SALQRARA.......--------.....-DKTYRRSYTHA
Q1PA44.1/13-143     --YPAASPVSMNTMtGmt...................gvGSMTS.MNSYSSMSTTg..mPGSAI.................TSMSGMTHAGMTGMSSMSS..MAGMGMNPGMGSMGHMN.........SMGSMNTMG-.SINGMNSMGA.MNNPAA.MS---------..MRYAQAQA.......ANSIDRIR.....ADKTYRRSYTHA
Q4H3J7.1/8-130      SKYQPFQQSYATGMnNmtngm.............qpsyvNQMNP.MSLTAAGNQV....----G.................FNQALPQGYGGVSFNGMGT..SAMNGHSPHSVQIA---.........---------A.AAAAAVGSPP.MGTAYA.GMPTGVGITPN..--MALMLN.......------RR.....TEKQYRRNYTHA
C3XR49.1/7-149      SAYEAQGGSPSSMQ.A.......................--MTA.MTTGNSYSPS....-----.................-SYTSSGYSVTQSMTTLGS..SYSTGMNGVGMGTIPPSht.....smTTMGMNSVPGsQLTTMSTMGA.QHPGLA.NSLGVGMAHPG..QSMSPMSMqg..svnGVNMNLTRedvlnRQKQYRRSYTHA
Q7PXZ4.4/5-163      --YPESSINTSSSM.AvgggggggggggggnmspmattySSMNS.MGMAVGGMTSv.spQGGGFga............tvlGSPGM-GGMG-AAMNSMSG..NCLTSTPIGYSSMGSPIsn.....mgSCMGGNGMST.MAAMSG-YSS.VAGSR-.-EVLGDPSSPN.sVALQRART.......------EK.....PAATYRRNYTHA
A0A444T114.1/20-142 ---------V----.Spms.................qtsYGMNS.MNSMMGMNSY....QQRLP.................PNMDFSSSMGSISAMGMSG..QCMSPSMTSM-GAFPPMn.......aPMQQMNGMS-.--GCMTTMGS.MGTMNQ.MV-------PY.gRELQEPDSp.....vSSALQRAR.....QDKTYRRSYTHA
V4B9B8.1/8-148      SYDPTSTGGYSMAS.M.......................PGINT.MGGVGPMSNMn.ysP---Qgmggm.......hsamnSMNTMPPAMGSMGLGSMAM..-HGSSMHGQVSAMNPMN.........TMGSMNSMG-.SMGSMNGMSS.IGSMSS.MNGINRPMDPN.mMSMDRAQA.......---LNRAR.....-DKNYRRSYTHA
A0A401NI77.1/18-151 TYYGEPQEVYSTVPvNs....................mnPGLSS.MNSYMAMNSM....GSGGNm..............tsGSFNM-SYGNPGMSTGLSP..-GMAGMPCSGAGAMNGM.........G----AAMGS.AISPN--MSS.---Q-Q.AP--MNALSPY..SSMSPAISpm..aysQSNLSRPR.....DSKTFRRTYPHA
E0W062.1/21-146     ---NMATTINSMAS.S.......................YSMNS.MACVSSMNSCs..pQSGSG.................FSSNM----LSSGMSSMNG..NCMS-SPMSYGSIGSPM.........--ANMNGVAS.CMGGMSSINS.YGGA--.-LTPVSSMSNT..RDLNPSSP......nSAALQRAR.....ADKTYRRSYTHA
A0A423U7B8.1/20-140 --------------.Pvspm...............sqttYGMNS.MNSMMGMNTY....QQRLP.................PNMDFSSSMTGIGAMGMGG..QCMSPGMTGM-GAFPPMn.......sSMQQMNGMSG.CMSGMGGMNQ.MVPY--.----GRELQEP..--DSPVSS.......--ALQRAR.....QDKTYRRSYTHA
A0A2J7Q4V9.1/30-159 --------VNSMSP.Mt....................ptYSMNS.MSCVSMNSCS...pQTAAT.................FGSNMLGSAM--GSINMNG..SCMSSTGMGYSSPMGNMn.......gVGSCMGSMGS.IQGYNGALAP.VGSMGV.GRGELGAVPGD.aGSPNSAAA.......---LQRAR.....NDKTYRRSYTHA
A0A210QCG1.1/32-152 -------GSNYPT-.S......................lPSMNS.IGNMGSMSTM....----A.................MSNVSYSPPAMGGMGTMTP..PGMTSMGMGAP-MGMPG........gMHAGMNSMN-.SMNGMSGMTS.MGQM-P.MNGMSGAMSP-..MRMDTFNR.......AQAINRAR.....-DKTYRRSYTHA
T1H7V7.1/71-185     -----------NVN.Mspt................mtstYNINS.MPCVSMNSSP....QAGSF.................STNMLGPHTGMGSMSAMNG..NCMSSSSMGYGNMNTVS.........NCMNINAYQM.STGLQN----.------.REAIGETVSP-..---SSVAA.......---LQRAR.....TDKSYRRSYTHA
Q17241.1/19-112     --------------.-.......................-----.----------....-----.................---SLSPGLAPPYVNGMGC..MPAQPYPNLYSNNM--V........aGGSCMGSPSV.GYSPPSTMAScMGGAGA.VP--YGSLPRE.qEAASPTSA.......---LQRAR.....NDKTYRRSYTHA
H9J6F9.1/19-112     --------------.-.......................-----.----------....-----.................---SLSPGLAPPYVNGMGC..MPAQPYPNLYSNNM--V........aGGSCMGSPSV.GYSPPSTMAScMGGAGA.VP--YGSLPRE.qEADSPTSA.......---LQRAR.....NDKTYRRSYTHA
A0A1J1J4N1.1/36-169 --------------.Nt....................nnGNMSP.MTPTYTMNTMg.mtG--MSsvspqgngsgsfgngvlTASNM-GAMS-SAMNAMNG..NCLTSTPIGYGSMGSPL........gNMGSCMGAGM.GTSMAS-MSQ.YTTMGR.GD-LQEPGSPN.sAVLQRARA.......-------E.....KPTTYRRSYTHA
A0A0L8FNY5.1/12-140 -----SSNNYAMTT.M.......................PGMNS.MGNVGSMNMS....SMAYSh...............qPMSNM-TSMN----PSLSG..MSMSGMGMHA-SMGAMNsmng.mgvgSMTPVNGVGVgSMGVGS-MNP.VNGVGV.GS--MRGVELN.mNSMNRAQA.......----MRA-.....RDKTYRRSYTHA
A0A1S3HM97.1/13-126 ------TSGYSM--.-.......................SSMPG.MNTAYGGMTS....---MG................yPQQTMQTMQTMGSMGGMPG..TGMGAMGM---------.........GHMGMTGMNMaNMGSMGGMNS.MG-MGT.MAGHMNGMSPS..--MSPVGL......dHQALNRAR.....-EKTYRRSYTHA
A0A2T7PG02.1/8-130  --YDATQAMSS---.-.......................YPMTS.MSSMGSMTSM....-GS--.................----M-GPLG--SMSTMSYspQTMPPMGGVSMGSMTPP.........-GMGVGGMPMgGMGMHTGISS.MGT-PP.MS-GMNGMSG-..MAMGGMRNtt...mdMMSINRAR.....HDKTYRRSYTHA
A0A482X9K7.1/12-122 -----S--VSS-AMgTna...................ptYGMNS.MMNSCSPQAA....---AA.................GSFNMLQGS--AAMAAMNG..NCMGGGAMGYGAQG---.........-------VG-.-SSCMGPYGA.---APL.TS--RTDVTPS..APPGEAAS.......PSALQRAR.....ADKSYRRSYTHA
K1QL47.1/11-136     ----NCSSGYPMTS.I.......................PSMNS.IGSMSMSMQS....-MAMT.................NNYS-PPSMG-GMAGTMTP..PGMTNLGMTP-----GMgmh...pgsMHAGMNSMN-.SMSPMNGMSS.MGGM-P.MNGMGAPMTP-..MRMESYNR.......AQAINRAR.....-DKSYRRSYTHA
A0A158NJ79.1/9-145  -LYGDAGAMTSAAMsSmgsm...............aptySSINS.MGCVPMGMSM....-GVGV.................GPSCSPQGAGGFNMSTMSS.aMGMASMGGGGM---SGY.........SGASMGAGGA.CMSAVG-YGP.LTPG--.-GGTGVSRDP-..LALTEPDS......pNSALQRAR.....SDKSYRRSYTHA
A0A2C9JEV0.1/21-128 --------------.G.......................NSINS.MGQSMSPMPS....-----.................-----------AAMSSIPP..MGYSPQSMTYLNTMNSM........gGMGAMGNMT-.SMTSMGGYGA.MAGNGM.G--AMAGISPI..GNRQFDQSlm...drNGSLNRPR.....TDKNYRRAYTHA
S4RKK9.1/16-160     SYYSDPAEGYSTVA.S.......................--MNSgLGGMAGMNYM....--SMTsmggs......galpsvPSYTG-GAALHAGSAAMGS..MAGGPVPMGGGGGVTALg.......gG---LGGVAG.AASP--GMSG.LSSQAG.SMQALGAYGPGvgAAVSPMGGy....gqANLANRAR.....DSKVYRRNYTHA
A0A4C1THA2.1/4-66   --------------.-.......................-----.----------....-----.................-------------------..---------------GG.........SCMGSPAVGY.--SPPTPSSM.ASCMAA.GGVGYAPLTRD.qDAASPTSA.......---LQRAR.....NDKTYRRSYTHA
A0A077Z0D9.1/46-163 --------------.-.......................-----.----------....----Ssata........aayanLSANMNASALNGPYSAMSS.fTGMNSMNGHPGLNGYGAmp....gmaTTMSSLSMGPtAMGSSA-LSP.LGCG-Q.MTVGVGSSTTP..TGAGVAQSg.....gASVSQRRN.....DKNSYRRSYTHA
A0A2G8LIB5.1/16-138 --------------.Ag.....................pGSMTN.MSMTSMAPAG....-MATA.................TMSPMNSYPGSMTMTSSGM..---HGGGTHMGAMGVNAqs....mgmGHSNMNGMG-.AMNSMQ-MSS.FGGMNM.AM-ANGMGSPM.tMRLAQAQA.......AVSLDRVR.....AEKSYRRSYTHA
C3XR51.1/1-92       --------------.-.......................--MNT.MSSMGGMNHA....-----.................-SYTGTGPVNPGAYSASAY.sGTMNGMGTGYPAAG---.........GMGGLQSYPAgSVNAMGTMQT.MNNM--.-A-----L---..-NRNAIAE.......--------.....REKAYRRSYTHA
A0A087UD34.1/69-165 --------------.-.......................-----.MGMGVGGTAG....---TC.................MSPTMTAMTPLGGMNSLNQ..-SMNGMTSPA-CMGSMT.........GLGSMNAPLV.AAAGRD-FGG.HGGAGD.GS---------..--ASAAT-.......-AALQRAR.....ADKTYRRSYSHA
P32183.1/16-118     SYYPEAGEVYSP--.-.......................--VNP.VPTMAPLNSY....-----.................-------------------..MSLNPLSSPYPP-----.........GGLQASPLPTgPLAPPAPTAP.LGPTFP.GLGA-GSGTGG..SASGYGAP......gPGLVHGKE.....MAKGYRRPLTHA
J9M3K2.2/175-250    --------------.-.......................-----.----------....-----.................-------------------..----GSSASAAANMQQQ.........LYGGMNSAAT.AAAAMYGLNAsAAAVAAaAAAAGAGGDP-..TGAANAAA.......---LQRVR.....ADKTYRRNYTHA
P35584.1/16-118     SYYPEAGEVYSP--.-.......................--VNP.VPTMAPLNSY....-----.................-------------------..MTLNPLSSPYPP-----.........GGLQASPLPTgPLAPPAPTAP.LGPTFP.SL--GTGGSTG.gSASGYVAP......gPGLVHGKE.....MAKGYRRPLAHA
A0A1S3D2C1.1/14-122 -----------PGM.Tp.....................sYSMNS.VINSCSPQSG....STG-Tpl.............ggFSSNM-HSMG--SINGMNG.pNCMSTGSMGYSSNMNAA.........CMGGINSYNT.ALTTGR--AE.------.----LAENSPS.pGALQRV--.......------AR.....ADKTYRRSYTHA
M7AZI7.1/6-109      --------------.-.......................GPMNT.INSYMTLNSL....--SSP.................SSINM-TYPNSPSLTGLTS..---STSPMGLPTMTSP-.........-------VS-.---PV--LTP.LGTQAP.T---INSLSPY..PNVSQSLApl..gypASGISRPK....eINKSYRRTLTHA
P55318.2/16-116     SYYPEAGEVYSP--.-.......................--VTP.VPTMAPLNSY....-----.................-------------------..MTLNPLSSPYPP-----.........GGLPASPLPSgPLAPPAPAAP.LGPTFP.GL--GVSGGSS.sSGYGAPG-.......PGLVHGKE.....MPKGYRRPLAHA
T1IV46.1/8-159      ---STD-NVSSSMStM.......................NTMNP.MTSSYSINGMggmgQMGMSyst...........qglGSNMLSAGG---SMTSMGG..MNGACMGSPVGPMASLSsmqsygsapTMTNMSSVPPaCMGSMS-PNG.MGAA--.MNGAMTPVSMN..--RDLASPganaaaaNAALQRVR.....ADKTYRRNYTHA
E9H4D8.1/65-179     --------------.-.......................-NISS.MSSCSPQTSA....AAAAA.................---AGSSV---FGMSNLGG..GNGGGAGQGHATMNNTT.........CMSPGMSVSG.SYAMRSGIDSgMGQ--C.MSSTFGGGVPS.sMGPSMGNT.......GNASSGGR....nDNKAYRRSYTHA
A0A0S2M610.1/31-113 --------------.-.......................---SH.LSYPTASNSS....----Fi..............ylMSQRQQGGGMGMGGMGMGG..MGMGGMGMGGMGMMNPM.........-MGGMGGMG-.MMNPMMGMGG.MGMASP.MM-GMGGY---..--------.......--------.....------------
A0A2B4SCA7.1/2-46   --------------.-.......................-----.----------....-----.................-------------------..-----------------.........----------.-------MEA.MNPGNP.AA-AMGVGNPQ..AQGHPLDD.......-SKSKQA-.....KEKVYRRSYTHA
A7S1E3.1/8-39       --------------.-.......................-----.----------....-----.................-------------------..-----------------.........----------.----------.------.--------PP-..AAMQDPSQ......nPHELKKSK....dKEKAYRRSYTHA
//