Summary: FR47-like protein
FR47-like protein Provide feedback
The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47 (Q9VR51). This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.
Internal database links
|Similarity to PfamA using HHSearch:||Acetyltransf_1 Gly_acyl_tr_C GNAT_acetyltran Acetyltransf_3 Acetyltransf_7 Acetyltransf_8 Acetyltransf_9 Acetyltransf_10 Acetyltransf_CG|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR013653
Proteins in this entry have a conserved region similar to the C-terminal region of the Drosophila melanogaster (Fruit fly) hypothetical protein FR47 (SWISSPROT). This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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This clan contains families related to N-acetyltransferases. N-acetyltransferases catalyse the transfer of acetyl groups from acetyl-CoA to arylamines.
The clan contains the following 31 members:Acetyltransf_1 Acetyltransf_10 Acetyltransf_13 Acetyltransf_3 Acetyltransf_4 Acetyltransf_5 Acetyltransf_6 Acetyltransf_7 Acetyltransf_8 Acetyltransf_9 Acetyltransf_CG ATE_C ATE_N Autoind_synth DUF1248 DUF1999 DUF2156 DUF3749 DUF482 DUF619 FemAB FR47 Gly_acyl_tr_C GNAT_acetyltr_2 GNAT_acetyltran Leu_Phe_trans Mec-17 Mig-14 MOZ_SAS NMT NodA
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- Pfam viewer
- an HTML-based viewer that uses DAS to retrieve alignment fragments on request
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_71946 (release 17.0)|
|Number in seed:||9|
|Number in full:||870|
|Average length of the domain:||82.70 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||31.53 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FR47 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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