Summary: SRP72 RNA-binding domain
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SRP72 RNA-binding domain Provide feedback
This region has been identified as the binding site of the SRP72 protein to SRP RNA .
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This tab holds annotation information from the InterPro database.
InterPro entry IPR013699
The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [PUBMED:17622352, PUBMED:16469117]. SRP recognises the signal sequence of the nascent polypeptide on the ribosome, retards its elongation, and docks the SRP-ribosome-polypeptide complex to the RER membrane via the SR receptor. Eukaryotic SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide 7S RNA molecule. The RNA component catalyses the interaction of SRP with its SR receptor [PUBMED:17507650]. In higher eukaryotes, the SRP complex consists of the Alu domain and the S domain linked by the SRP RNA. The Alu domain consists of a heterodimer of SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. This domain is necessary for retarding the elongation of the nascent polypeptide chain, which gives SRP time to dock the ribosome-polypeptide complex to the RER membrane. In archaea, the SRP complex contains 7S RNA like its eukaryotic counterpart, yet only includes two of the six protein subunits found in the eukarytic complex: SRP19 and SRP54 [PUBMED:12364595].
This entry represents the RNA binding domain of the SRP72 subunit. This domain is responsible for the binding of SRP72 to the 7S SRP RNA [PUBMED:15588816].
|Cellular component||signal recognition particle (GO:0048500)|
|Molecular function||7S RNA binding (GO:0008312)|
|Biological process||SRP-dependent cotranslational protein targeting to membrane (GO:0006614)|
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Curation and family details
|Seed source:||Pfam-B_7529 (Release 18.0)|
|Author:||Zwieb C, Rosenblad MA, Bateman A|
|Number in seed:||19|
|Number in full:||306|
|Average length of the domain:||65.40 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||10.29 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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