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27  structures 407  species 0  interactions 6305  sequences 125  architectures

Family: ADAM_CR (PF08516)

Summary: ADAM cysteine-rich

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The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ADAM cysteine-rich Provide feedback

ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity [1].

Literature references

  1. Smith KM, Gaultier A, Cousin H, Alfandari D, White JM, DeSimone DW; , J Cell Biol 2002;159:893-902.: The cysteine-rich domain regulates ADAM protease function in vivo. PUBMED:12460986 EPMC:12460986


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR006586

An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain (MEROPS peptidase family M12B). All members of the ADAM family display a common domain organisation - a pro-domain, the metalloprotease, disintigrin, cysteine-rich, epidermal-growth factor like, and transmembrane domains and a C-terminal cytoplasmic tail. They possess four potential functions: proteolysis, cell adhesion, cell fusion, and cell signalling. ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. They are responsible for the proteolytic cleavage of transmembrane proteins and release of their extracellular domain [ PUBMED:11193153 , PUBMED:12514095 ].

The ADAM cysteine-rich domain is not found in plant, archaeal, bacterial or viral proteins. The cysteine-rich domain complements the binding capacity of the disintegrin domain, and perhaps imparts specificity to disintegrin domain-mediated interactions. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity [ PUBMED:12460986 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(333)
Full
(6305)
Representative proteomes UniProt
(11035)
RP15
(560)
RP35
(1779)
RP55
(5071)
RP75
(7302)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(333)
Full
(6305)
Representative proteomes UniProt
(11035)
RP15
(560)
RP35
(1779)
RP55
(5071)
RP75
(7302)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(333)
Full
(6305)
Representative proteomes UniProt
(11035)
RP15
(560)
RP35
(1779)
RP55
(5071)
RP75
(7302)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_197 (release 18.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Wuster A
Number in seed: 333
Number in full: 6305
Average length of the domain: 113.70 aa
Average identity of full alignment: 32 %
Average coverage of the sequence by the domain: 14.59 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 29.4 29.4
Trusted cut-off 29.5 29.4
Noise cut-off 29.3 29.3
Model length: 116
Family (HMM) version: 14
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ADAM_CR domain has been found. There are 27 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JX23 View 3D Structure Click here
A0A0G2K0E8 View 3D Structure Click here
A0A0G2K693 View 3D Structure Click here
A0A0R4INJ8 View 3D Structure Click here
A0A1W2Q6C2 View 3D Structure Click here
A0A2R8Q0T5 View 3D Structure Click here
A0A2R8Q748 View 3D Structure Click here
A2RSG8 View 3D Structure Click here
B2RSY5 View 3D Structure Click here
B2RUD9 View 3D Structure Click here
D3ZB52 View 3D Structure Click here
D3ZEP8 View 3D Structure Click here
D3ZIP6 View 3D Structure Click here
D3ZPM7 View 3D Structure Click here
D3ZT36 View 3D Structure Click here
E7F494 View 3D Structure Click here
E7F698 View 3D Structure Click here
E7F6J8 View 3D Structure Click here
E7FGJ0 View 3D Structure Click here
E9PTA4 View 3D Structure Click here
E9PTQ3 View 3D Structure Click here
F1LW54 View 3D Structure Click here
F1LWE4 View 3D Structure Click here
F1LXB5 View 3D Structure Click here
F1M8J6 View 3D Structure Click here
F1M9Z9 View 3D Structure Click here
F1Q4N9 View 3D Structure Click here
F1QDC4 View 3D Structure Click here
F1QF43 View 3D Structure Click here
F1QFD2 View 3D Structure Click here
F1QU24 View 3D Structure Click here
F8VQ03 View 3D Structure Click here
F8W3T1 View 3D Structure Click here
G3V9N4 View 3D Structure Click here
G5EDW5 View 3D Structure Click here
G5EFD5 View 3D Structure Click here
M0R5P8 View 3D Structure Click here
O35227 View 3D Structure Click here
O35674 View 3D Structure Click here
O43184 View 3D Structure Click here
O43506 View 3D Structure Click here
O75077 View 3D Structure Click here
O75078 View 3D Structure Click here
O88839 View 3D Structure Click here
P70505 View 3D Structure Click here
P78325 View 3D Structure Click here
P97776 View 3D Structure Click here
Q05910 View 3D Structure Click here
Q13443 View 3D Structure Click here
Q13444 View 3D Structure Click here
Q3B7V9 View 3D Structure Click here
Q3TTE0 View 3D Structure Click here
Q5BK84 View 3D Structure Click here
Q60718 View 3D Structure Click here
Q60813 View 3D Structure Click here
Q61072 View 3D Structure Click here
Q61824 View 3D Structure Click here
Q63180 View 3D Structure Click here
Q63202 View 3D Structure Click here
Q6IMH6 View 3D Structure Click here
Q6IMH7 View 3D Structure Click here
Q6NVV9 View 3D Structure Click here
Q6QU65 View 3D Structure Click here
Q7M762 View 3D Structure Click here
Q7M763 View 3D Structure Click here
Q7M766 View 3D Structure Click here
Q7ZYZ9 View 3D Structure Click here
Q811Q3 View 3D Structure Click here
Q811Q4 View 3D Structure Click here
Q8CGQ2 View 3D Structure Click here
Q8K410 View 3D Structure Click here
Q8R534 View 3D Structure Click here
Q8TC27 View 3D Structure Click here
Q923W9 View 3D Structure Click here
Q99965 View 3D Structure Click here
Q9BZ11 View 3D Structure Click here
Q9H013 View 3D Structure Click here
Q9H2U9 View 3D Structure Click here
Q9JI76 View 3D Structure Click here
Q9JLN6 View 3D Structure Click here
Q9P0K1 View 3D Structure Click here
Q9QYV0 View 3D Structure Click here
Q9R157 View 3D Structure Click here
Q9R158 View 3D Structure Click here
Q9R159 View 3D Structure Click here
Q9R160 View 3D Structure Click here
Q9R1V4 View 3D Structure Click here
Q9R1V6 View 3D Structure Click here
Q9R1V7 View 3D Structure Click here
Q9UKF2 View 3D Structure Click here
Q9UKF5 View 3D Structure Click here
Q9UKJ8 View 3D Structure Click here
Q9UKQ2 View 3D Structure Click here
Q9Y3Q7 View 3D Structure Click here
X2JE21 View 3D Structure Click here