Summary: Lethal giant larvae(Lgl) like, C-terminal
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The Lethal giant larvae (Lgl) tumour suppressor family is conserved from yeast to mammals. The Lgl family functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface . The N-terminal half of Lgl members contains WD40 repeats (see PF00400), while the C-terminal half appears specific to the family .
Gangar A, Rossi G, Andreeva A, Hales R, Brennwald P; , Curr Biol. 2005;15:1136-1142.: Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function. PUBMED:15964280 EPMC:15964280
This tab holds annotation information from the InterPro database.
InterPro entry IPR013905
The Lethal giant larvae (Lgl) tumour suppressor protein is conserved from yeast to mammals. The Lgl protein functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface [PUBMED:15964280]. The N-terminal half of Lgl members contains WD40 repeats (see INTERPRO), while the C-terminal half appears specific to the protein [PUBMED:15964280].
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This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled. The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.
The clan contains the following 70 members:ANAPC4_WD40 Arylesterase Arylsulfotran_2 Arylsulfotrans BBS2_Mid Beta_propel Coatomer_WDAD CPSF_A Cytochrom_D1 DPPIV_N DUF1513 DUF1668 DUF2415 DUF3312 DUF4221 DUF4934 DUF5050 DUF5122 DUF5128 DUF839 eIF2A FG-GAP FG-GAP_2 Ge1_WD40 Glu_cyclase_2 Gmad1 GSDH IKI3 Itfg2 Kelch_1 Kelch_2 Kelch_3 Kelch_4 Kelch_5 Kelch_6 Lactonase Ldl_recept_b Lgl_C LVIVD Me-amine-dh_H MRJP Nbas_N Neisseria_PilC NHL Nucleoporin_N Nup160 PALB2_WD40 PD40 Pectate_lyase22 Peptidase_S9_N Phytase-like PQQ PQQ_2 PQQ_3 RAG2 RCC1 RCC1_2 Reg_prop SBBP SBP56 SdiA-regulated SGL Str_synth TcdB_toxin_midN TolB_like VCBS WD40 WD40_3 WD40_4 WD40_like
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Curation and family details
|Author:||Wood V, Finn RD|
|Number in seed:||13|
|Number in full:||408|
|Average length of the domain:||281.30 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||27.99 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Lgl_C domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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