Summary: Utp13 specific WD40 associated domain
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Utp13 specific WD40 associated domain Provide feedback
Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome . Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end .
Dosil M, Bustelo XR; , J Biol Chem. 2004;279:37385-37397.: Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. PUBMED:15231838 EPMC:15231838
Internal database links
|Similarity to PfamA using HHSearch:||Utp12 UTP15_C|
This tab holds annotation information from the InterPro database.
InterPro entry IPR013934
A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA - the small-subunit (SSU) processome [PUBMED:12068309, PUBMED:15590835]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties:
- They are nucleolar.
- They are able to coimmunoprecipitate with the U3 snoRNA and Mpp10 (a protein specific to the SSU processome).
- They are required for 18S rRNA biogenesis.
There appears to be a linkage between polymerase I transcription and the formation of the SSU processome; as some, but not all, of the SSU processome components are required for pre-rRNA transcription initiation. These SSU processome components have been termed t-Utps. They form a pre-complex with pre-18S rRNA in the absence of snoRNA U3 and other SSU processome components. It has been proposed that the t-Utp complex proteins are both rDNA and rRNA binding proteins that are involved in the initiation of pre18S rRNA transcription. Initially binding to rDNA then associating with the 5' end of the nascent pre18S rRNA. The t-Utpcomplex forms the nucleus around which the rest of the SSU processome components, including snoRNA U3, assemble [PUBMED:15489292]. From electron microscopy the SSU processome may correspond to the terminal knobs visualized at the 5' ends of nascent 18S rRNA.
Utp13 is a nucleolar protein and component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [PUBMED:12068309].
Upt13 is also a component of the Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [PUBMED:15231838]. Components of the Pwp2 complex are: Utp1 (Pwp2), Utp6, Utp12 (Dip2), Utp13, Utp18, and Utp21. The relationship between the Pwp2 complex and the t-Utps complex [PUBMED:15489292] that also associates with the 5' end of nascent pre-18S rRNA is unclear.
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|Cellular component||small-subunit processome (GO:0032040)|
|Biological process||rRNA processing (GO:0006364)|
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Curation and family details
|Seed source:||Pfam-B_8625 (release 19.0)|
|Author:||Wood V, Finn RD|
|Number in seed:||164|
|Number in full:||802|
|Average length of the domain:||145.00 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||16.97 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Utp13 domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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