Summary: Glycolipid transfer protein (GLTP)
This is the Wikipedia entry entitled "Glycolipid transfer protein". More...
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Glycolipid transfer protein Edit Wikipedia article
|Glycolipid transfer protein (GLTP)|
This protein transports primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.
Human proteins containing this domain
- Brown RE, Lin X, Rao CS, Pike HM, Molotkovsky JG (2004). "Glycolipid Transfer Protein Mediated Transfer of Glycosphingolipids between Membranes: A Model for Action Based on Kinetic and Thermodynamic Analyses". Biochemistry. 43 (43): 13805–15. doi:10.1021/bi0492197. PMC . PMID 15504043.
- Nymalm Y, Airenne TT, Kidron H, Salminen TA, Nylund M, West G, Mattjus P (2006). "Structural evidence for adaptive ligand binding of glycolipid transfer protein". J. Mol. Biol. 355 (2): 224–36. doi:10.1016/j.jmb.2005.10.031. PMID 16309699.
- Metz, RJ, and Radin, NS. Glucosylceramide Uptake Protein from Spleen Cytosol. Journal of Biological Chemistry. 1980;255(10):4463–67. PMID 7372587.
- Metz, RJ, and Radin NS. Purification and Properties of a Cerebroside Transfer Protein. Journal of Biological Chemistry. 1982;257(21):12901–07. PMID 7130186.
- Mattjus P. Glycolipid transfer proteins and membrane interaction. Biochimica et Biophysica Acta. 2009;1788:267–72. doi:10.1016/j.bbamem.2008.10.003. PMID 19007748.
- Brown RE, and Mattjus P. Glycolipid transfer proteins. Biochimica et Biophysica Acta. 2007;1771:746-60. doi:10.1016/j.bbalip.2007.01.011. PMID 17320476.
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Glycolipid transfer protein (GLTP) Provide feedback
GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids .
Rao CS, Lin X, Pike HM, Molotkovsky JG, Brown RE; , Biochemistry. 2004;43:13805-13815.: Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses. PUBMED:15504043 EPMC:15504043
Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA; , J Mol Biol. 2006;355:224-236.: Structural evidence for adaptive ligand binding of glycolipid transfer protein. PUBMED:16309699 EPMC:16309699
Malinina L, Malakhova ML, Kanack AT, Lu M, Abagyan R, Brown RE, Patel DJ; , PLoS Biol. 2006;4:e362.: The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure. PUBMED:17105344 EPMC:17105344
Rao CS, Chung T, Pike HM, Brown RE; , Biophys J. 2005;89:4017-4028.: Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition. PUBMED:16169991 EPMC:16169991
This tab holds annotation information from the InterPro database.
InterPro entry IPR014830
Glycolipid transfer protein (GLTP) is a cytosolic protein that catalyses the intermembrane transfer of glycolipids such as glycosphingolipids, glyceroglycolipids, and possibly glucosylceramides, but not of phospholipids. The GLTP protein consists of a single domain with a multi-helical structure consisting of two layers of orthogonally packed helices [PUBMED:15504043, PUBMED:16309699].
The GLTP domain is also found in trans-Golgi network proteins involved in Golgi-to-cell-surface membrane traffic [PUBMED:15107860].
|Cellular component||cytoplasm (GO:0005737)|
|Molecular function||glycolipid transporter activity (GO:0017089)|
|glycolipid binding (GO:0051861)|
|Biological process||glycolipid transport (GO:0046836)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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Curation and family details
|Number in seed:||278|
|Number in full:||1730|
|Average length of the domain:||137.00 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||54.49 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GLTP domain has been found. There are 74 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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