Summary: HPC2 and ubinuclein domain
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HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription . It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes . Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci . HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails . This domain is also referred to as the HRD or Hpc2-related domain.
Xu H, Kim UJ, Schuster T, Grunstein M; , Mol Cell Biol. 1992;12:5249-5259.: Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. PUBMED:1406694 EPMC:1406694
Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, Rhoades AR, Kaufman PD, Stillman DJ; , Genetics. 2002;162:1557-1571.: Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. PUBMED:12524332 EPMC:12524332
Anderson HE, Kagansky A, Wardle J, Rappsilber J, Allshire RC, Whitehall SK;, PLoS One. 2010;5:e13488.: Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4. PUBMED:20976105 EPMC:20976105
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014840
HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription [PUBMED:1406694]. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes [PUBMED:12524332].
This short domain is referred to as the HRD or Hpc2-related domain and is found in both human, yeast and Sch. pombe sequences. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication-independent nucleosome assembly, along with histone chaperone proteins. The Hip4 sequence from Sch. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci [PUBMED:20976105].
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Curation and family details
|Previous IDs:||HPC2; HRD;|
|Author:||Mistry J, Wood V, Balaji S, Iyer LM, Aravind L|
|Number in seed:||54|
|Number in full:||344|
|Average length of the domain:||52.80 aa|
|Average identity of full alignment:||40 %|
|Average coverage of the sequence by the domain:||6.69 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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