# STOCKHOLM 1.0 #=GF ID HUN #=GF AC PF08729.12 #=GF DE HPC2 and ubinuclein domain #=GF PI HPC2; HRD; #=GF AU Mistry J;0000-0003-2479-5322 #=GF AU Wood V;0000-0001-6330-7526 #=GF AU Balaji S; #=GF AU Iyer LM;0000-0002-4844-2022 #=GF AU Aravind L;0000-0003-0771-253X #=GF SE manual #=GF GA 26.90 26.90; #=GF TC 26.90 26.90; #=GF NC 26.80 26.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 1406694 #=GF RT Identification of a new set of cell cycle-regulatory genes that #=GF RT regulate S-phase transcription of histone genes in Saccharomyces #=GF RT cerevisiae. #=GF RA Xu H, Kim UJ, Schuster T, Grunstein M; #=GF RL Mol Cell Biol. 1992;12:5249-5259. #=GF RN [2] #=GF RM 12524332 #=GF RT Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae #=GF RT cause dependence on the Hir/Hpc pathway: polymerase passage may #=GF RT degrade chromatin structure. #=GF RA Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, #=GF RA Rhoades AR, Kaufman PD, Stillman DJ; #=GF RL Genetics. 2002;162:1557-1571. #=GF RN [3] #=GF RM 20976105 #=GF RT Silencing mediated by the Schizosaccharomyces pombe HIRA complex #=GF RT is dependent upon the Hpc2-like protein, Hip4. #=GF RA Anderson HE, Kagansky A, Wardle J, Rappsilber J, Allshire RC, #=GF RA Whitehall SK; #=GF RL PLoS One. 2010;5:e13488. #=GF RN [4] #=GF RM 19225618 #=GF RT HPC2 and ubinuclein define a novel family of histone chaperones #=GF RT conserved throughout eukaryotes. #=GF RA Balaji S, Iyer LM, Aravind L; #=GF RL Mol Biosyst. 2009;5:269-75. #=GF DR INTERPRO; IPR014840; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC HPC2 (Histone promoter control 2) is required for cell-cycle #=GF CC regulation of histone transcription [1]. It regulates #=GF CC transcription of the histone genes during the S-phase of the #=GF CC cell cycle by repressing transcription at other cell cycle #=GF CC stages. HPC2 mutants display synthetic interactions with FACT #=GF CC complex which allows RNA Pol II to elongate through nucleosomes #=GF CC [2]. Hpc2 is one of the proteins of one of the multi-subunit #=GF CC complexes that mediate replication- independent nucleosome #=GF CC assembly, along with histone chaperone proteins. the Hip4 #=GF CC sequence from SCH. pombe is an integral component of this #=GF CC complex that is required for transcriptional silencing at #=GF CC multiple loci [3]. HPC2, ubinuclein/yemanuclein, and the cell #=GF CC cycle regulator FLJ25778 share a conserved domain that is #=GF CC predicted to bind histone tails [4]. This domain is also #=GF CC referred to as the HRD or Hpc2-related domain. #=GF SQ 35 #=GS W4XAC8_STRPU/96-147 AC W4XAC8.1 #=GS H2Y080_CIOIN/91-142 AC H2Y080.1 #=GS K1R3N7_CRAGI/102-153 AC K1R3N7.1 #=GS G3NRI2_GASAC/26-77 AC G3NRI2.1 #=GS T1K7Z6_TETUR/80-131 AC T1K7Z6.1 #=GS A0A068YBD9_ECHMU/71-122 AC A0A068YBD9.1 #=GS D2VB82_NAEGR/219-277 AC D2VB82.1 #=GS A0BCW0_PARTE/59-101 AC A0BCW0.1 #=GS Q5CUP5_CRYPI/223-272 AC Q5CUP5.1 #=GS A7APV8_BABBO/204-259 AC A7APV8.1 #=GS Q4UDH0_THEAN/221-276 AC Q4UDH0.1 #=GS S8FP03_FOMPI/160-208 AC S8FP03.1 #=GS Q5K8G8_CRYNJ/340-384 AC Q5K8G8.2 #=GS Q55BH3_DICDI/342-405 AC Q55BH3.1 #=GS M9ME25_PSEA3/338-388 AC M9ME25.1 #=GS C1E748_MICCC/263-319 AC C1E748.1 #=GS H3HB60_PHYRM/316-371 AC H3HB60.1 #=GS F4HY28_ARATH/114-164 AC F4HY28.1 #=GS M0S3T3_MUSAM/125-176 AC M0S3T3.1 #=GS A0A3Q7JHC1_SOLLC/120-170 AC A0A3Q7JHC1.1 #=GS F4P2R4_BATDJ/171-224 AC F4P2R4.1 #=GS Q8ST29_ENCCU/29-71 AC Q8ST29.2 #=GS H3EZQ8_PRIPA/82-133 AC H3EZQ8.2 #=GS B3RWG6_TRIAD/106-157 AC B3RWG6.1 #=GS E9H1Q2_DAPPU/117-168 AC E9H1Q2.1 #=GS K7IYJ0_NASVI/109-159 AC K7IYJ0.1 #=GS D2A104_TRICA/104-155 AC D2A104.2 #=GS H9JIL7_BOMMO/96-147 AC H9JIL7.1 #=GS B3MT43_DROAN/124-175 AC B3MT43.2 #=GS B4JRR1_DROGR/127-177 AC B4JRR1.1 #=GS Q7PYP4_ANOGA/156-205 AC Q7PYP4.5 #=GS J9KB78_ACYPI/122-173 AC J9KB78.2 #=GS A7RVJ6_NEMVE/100-151 AC A7RVJ6.1 #=GS H2ZRP9_LATCH/121-172 AC H2ZRP9.1 #=GS H3CS34_TETNG/106-157 AC H3CS34.1 W4XAC8_STRPU/96-147 KKKMILEDLIDAGMGYDVDDPFVD............NSE...CYDELVPA....SLTTQFGG.....FYINSGQLK H2Y080_CIOIN/91-142 RRRDRIQDLADVGYGYDETDPFVD............DSE...CYDEMVPS....SLTTQFGG.....FYVNTGKLE K1R3N7_CRAGI/102-153 SRAGRITDLVDLGDGYDQEDPFID............NSE...AYDEVVPL....CLTTKLGG.....FYINSGKLD G3NRI2_GASAC/26-77 KKKDRMQDLIDIGYGYDETDPFID............NSE...AYDELVPA....SLTTKHGG.....FYINTGTLQ T1K7Z6_TETUR/80-131 KGKGFLEDFIDKGYGYDETDPFID............NSE...AYDELVPS....TMSTKYGG.....FYINTGLLE A0A068YBD9_ECHMU/71-122 RRRLRVDDFIDLGEGYDSQDSFID............DSE...AVELVVAP....TLRTRHGG.....FFVNEGFLE D2VB82_NAEGR/219-277 KSTKKKKEEEKRRFDYDSEDSFID............DTEYDVIATDFPMIPHQEAQQLEKHT.....FYDDEDSEE A0BCW0_PARTE/59-101 GAMQKDFDYEKGQNVYDQDDSFID............DEE................IDKENHA.....MVIPETELD Q5CUP5_CRYPI/223-272 GANRSREDY......YDVFDDFID............DSE...LVDDLGLSLDELYSRNADRG.....NHTADQGDD A7APV8_BABBO/204-259 GDPVSYLKIGGDDMHYDIDDPFID............DRD...MFNELQISRDDLMMKKAMEK.....DFSVWSEDE Q4UDH0_THEAN/221-276 GDPTSYLKKGGDDMHYDMDDPFFD............DSA...MLSELKMSKSDILLKRAMEK.....EFSDWSEDE S8FP03_FOMPI/160-208 KKRRKKKNRASEY..YDTADPFID............DSE...LAQDERTF....FAQTKQKG.....FYVSSGQV. Q5K8G8_CRYNJ/340-384 KKKKRPTD.......YDLEDPFID............DSE...IMIDAPTH....YARPAREG.....FFVHSGPLQ Q55BH3_DICDI/342-405 FHYYLDSDGDSTISEYDIEDPFVDDSLLLIKDHAHSDSN...GIDDDSDD....INNLETNG.....FYVIQNGID M9ME25_PSEA3/338-388 KRRKVNDDKYDIG.QYDVRDPFVD............DSE...LNIDEPTH....FAKPKADG.....FYVTQGTVE C1E748_MICCC/263-319 KQQKRGGKNQYVEEWYDMDDDFID............DDE...LDEYFERT....GRKDKLGGKGGDRFYVNAGQIE H3HB60_PHYRM/316-371 GDEGGGLDRRDDDDLYDSEDSFID............DVE...LQQNIEDARGQTRVQTKHVG.....FFVNAGEEI F4HY28_ARATH/114-164 .SDGEELDGAPDDDEYDTEDSFID............DAE...LDEYFEVD....NSTVKHDG.....FYVNRGKLE M0S3T3_MUSAM/125-176 QSSDEELDDIPCDDQYDTEDSFID............DTE...LDEYFQVD....KMSTKHNG.....YFVNKGKLE A0A3Q7JHC1_SOLLC/120-170 .DDEEDLNDFPDDDEYDTEDSFID............DTE...LDEYFQVD....NSAIKHDG.....FFVNRGKLE F4P2R4_BATDJ/171-224 KPVKKTTNVADAECNYDLEDDFID............DSE...MFTDAMEGV..EEVPEWDFG.....YFVWHGSVE Q8ST29_ENCCU/29-71 KRRQRTDE.......YDYNDPFIE............PFE...GETEMV......MIECNLED.....FFVYKGELP H3EZQ8_PRIPA/82-133 KVKYNEDDFIQKSLGYDMEDEFID............DSE...AHDELVPS....TLDTKKGG.....FYVNKGVLE B3RWG6_TRIAD/106-157 HRTKAKDHVAYRAHGYDANDTFID............DNQ...HCDENIPN....NVTFKYGG.....FYINSNEVE E9H1Q2_DAPPU/117-168 KKSRKYDEYVDLGAGYDENDPFID............NTD...AYDEIVPA....EVTTAHGG.....FYINSGALE K7IYJ0_NASVI/109-159 .GNRKKNDYVDLGAGYDENDSFID............NTD...AYDELVPE....DITTAFGG.....FYVNSGALV D2A104_TRICA/104-155 KRKGRKDDYADIGMGYDESDSFID............NTD...GYDEMIPQ....NVTTLHGG.....FYINSGALE H9JIL7_BOMMO/96-147 KGRSKMDEFADIGAGYDETDSFID............NTH...GYDEMIPP....DRDTLHGG.....FYINCGDLE B3MT43_DROAN/124-175 RGKSKKDDYRDIGMGYDESDSFID............NTE...AYDEIIPE....EAETLKGG.....FYINCGALE B4JRR1_DROGR/127-177 .GRRKKNEFCDIGMGYDETDSFID............NTE...AYDEILPE....EVETLQGG.....FYINCGALV Q7PYP4_ANOGA/156-205 ..RPSKLDYYDRGAGYDEEDSFID............NSE...AYDELIPQ....EIETVGGG.....FYINSGQLE J9KB78_ACYPI/122-173 KKKTAFYNYSELAAGYDESDSFID............NTE...ICDEVMPK....EVETKHGG.....YYVNSGSLE A7RVJ6_NEMVE/100-151 RRQERIADLVDVTYGYDENDPFVD............NSE...AYDELIPV....DWTTEHGG.....FYINQGSLN H2ZRP9_LATCH/121-172 RRRDRIQDLIDMGYGYDDSDSFID............NSE...AYDELVPA....SLNTKYGG.....FYINSGTLQ H3CS34_TETNG/106-157 RKSDRIQDLIDFGYGYDEDDSFID............NTE...PYDEYVPA....SLTTMLSG.....FYVNSGVLQ #=GC seq_cons +cppchpDhhchshsYDpsDsFID............soE...hh-Ehhss....phpTppsG.....FYlNsGpL- //