Summary: Transcription factor AFT
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AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis . This family includes the paralogous pair of transcription factors AFT1 and AFT2.
Casas C, Aldea M, Espinet C, Gallego C, Gil R, Herrero E; , Yeast. 1997;13:621-637.: The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae. PUBMED:9200812 EPMC:9200812
Rutherford JC, Jaron S, Winge DR; , J Biol Chem. 2003;278:27636-27643.: Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. PUBMED:12756250 EPMC:12756250
Babu MM, Iyer LM, Balaji S, Aravind L; , Nucleic Acids Res. 2006; [Epub ahead of print]: The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons. PUBMED:17130173 EPMC:17130173
Internal database links
|Similarity to PfamA using HHSearch:||DBD_Tnp_Mut|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014842
AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis. This entry includes the paralogous pair of transcription factors AFT1 and AFT2.
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WRKY and GCM1 are metal chelating DNA-binding domains (DBD) which share a four stranded fold . We present evidence that they share a stabilising core, which suggests a possible origin from a BED finger-like intermediate that was in turn ultimately derived from a C2H2 Zn-finger domain .
The clan contains the following 6 members:AFT DBD_Tnp_Mut FAR1 FLYWCH GCM WRKY
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Curation and family details
|Author:||Mistry J, Wood V|
|Number in seed:||8|
|Number in full:||82|
|Average length of the domain:||88.90 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||18.93 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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