Summary: CRPV capsid protein like
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CRPV capsid protein like Provide feedback
This is a family of capsid proteins found in positive stranded ssRNA viruses such as cricket paralysis virus (CRPV). It forms an all beta sheet structure .
Tate J, Liljas L, Scotti P, Christian P, Lin T, Johnson JE; , Nat Struct Biol. 1999;6:765-774.: The crystal structure of cricket paralysis virus: the first view of a new virus family. PUBMED:10426956 EPMC:10426956
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014872
This domain is found in the Dicistroviruses (Picornavirus) that include Cripavirus capsid proteins, (which are positive stranded ssRNA viruses) such as Cricket paralysis virus (CRPV). It forms an all beta sheet structure [PUBMED:10426956].
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The clan contains a set of viral coat protein families and peptidase A6. The only known peptidase activity is an autolytic cleavage releasing a 44-residue C-terminal fragment. The reaction is very slow and only occurs within the assembled virion. There is debate whether this is actually a true peptidase. The virion with these coat or capsid proteins are icosahedral viruses containing sixty triangular coat protein units, each unit consisting of three proteins. The coat protein consists of two subdomains, an eight-stranded beta-barrel on the surface and a three-helix bundle on the inner face.
The clan contains the following 17 members:Birna_VP2 Bromo_coat Calici_coat Capsid-VNN Circo_capsid Como_LCP CRPV_capsid Cucumo_coat Luteo_coat Nepo_coat Peptidase_A21 Peptidase_A6 Rhv SP2 TT_ORF1 Tymo_coat Viral_coat
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Curation and family details
|Number in seed:||7|
|Number in full:||192|
|Average length of the domain:||163.40 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||24.60 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CRPV_capsid domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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