# STOCKHOLM 1.0 #=GF ID HIRAN #=GF AC PF08797.12 #=GF DE HIRAN domain #=GF AU Iyer LM;0000-0002-4844-2022 #=GF SE Iyer L #=GF GA 24.70 24.70; #=GF TC 24.70 24.70; #=GF NC 24.60 24.60; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cut_ga HMM metaseq #=GF TP Domain #=GF RN [1] #=GF RM 16627993 #=GF RT The HIRAN domain and recruitment of chromatin remodeling and #=GF RT repair activities to damaged DNA. #=GF RA Iyer LM, Babu MM, Aravind L; #=GF RL Cell Cycle. 2006;5:775-782. #=GF DR INTERPRO; IPR014905; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC The HIRAN domain (HIP116, Rad5p N-terminal) is found in the #=GF CC N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 #=GF CC and Rad5p. The HIRAN domain is found as a standalone protein in #=GF CC several bacteria and prophages, or fused to other catalytic #=GF CC domains, such as a nuclease of the restriction endonuclease fold #=GF CC and TDP1-like DNA phosphoesterases, in the eukaryotes [1]. It #=GF CC has been predicted that this domain functions as a DNA-binding #=GF CC domain that probably recognises features associated with damaged #=GF CC DNA or stalled replication forks [1] #=GF SQ 35 #=GS ECH76192.1/30-99 DE [subseq from] hypothetical protein GOS_3979435 [marine metagenome] #=GS EBO63721.1/52-142 DE [subseq from] hypothetical protein GOS_8046692 [marine metagenome] #=GS EBX73920.1/12-93 DE [subseq from] hypothetical protein GOS_6540528 [marine metagenome] #=GS 2000412030/34-123 DE [subseq from] '[Sludge/Australian, Phrap Assembly]' #=GS 2000115980/34-123 DE [subseq from] '[Sludge/US, Phrap Assembly]' #=GS 2000178390/34-123 DE [subseq from] '[Sludge/US, Phrap Assembly]' #=GS 2001020610/34-123 DE [subseq from] '[Sludge/US, Jazz Assembly]' #=GS EBG54264.1/14-92 DE [subseq from] hypothetical protein GOS_9415665 [marine metagenome] #=GS 2004004918/10-91 DE [subseq from] '[Human Gut Community Subject 7]' #=GS 2004002365/15-107 DE [subseq from] '[Human Gut Community Subject 7]' #=GS 2004040867/10-91 DE [subseq from] '[Human Gut Community Subject 8]' #=GS EBF88537.1/5-111 DE [subseq from] hypothetical protein GOS_9524812 [marine metagenome] #=GS 2004040927/3-55 DE [subseq from] '[Human Gut Community Subject 8]' #=GS 2004006303/10-64 DE [subseq from] '[Human Gut Community Subject 7]' #=GS EBF20242.1/61-120 DE [subseq from] hypothetical protein GOS_9636325 [marine metagenome] #=GS EBF20506.1/61-120 DE [subseq from] hypothetical protein GOS_9635881 [marine metagenome] #=GS EBF32622.1/49-152 DE [subseq from] hypothetical protein GOS_9616156 [marine metagenome] #=GS EBF70672.1/92-137 DE [subseq from] hypothetical protein GOS_9553905 [marine metagenome] #=GS ECW15383.1/30-98 DE [subseq from] hypothetical protein GOS_2771242 [marine metagenome] #=GS ECW09508.1/92-149 DE [subseq from] hypothetical protein GOS_2781545 [marine metagenome] #=GS EBF76019.1/54-152 DE [subseq from] hypothetical protein GOS_9545000 [marine metagenome] #=GS EDJ05484.1/54-152 DE [subseq from] hypothetical protein GOS_1762753 [marine metagenome] #=GS EBF14316.1/49-151 DE [subseq from] hypothetical protein GOS_9645877 [marine metagenome] #=GS 2001253010/136-207 DE [subseq from] '[Soil: Diversa Silage]' #=GS 2004037144/89-138 DE [subseq from] '[Human Gut Community Subject 8]' #=GS 2004003858/90-139 DE [subseq from] '[Human Gut Community Subject 7]' #=GS 2004040902/57-117 DE [subseq from] '[Human Gut Community Subject 8]' #=GS 2000336500/4-65 DE [subseq from] '[Sludge/US, Phrap Assembly]' #=GS 2004029763/203-252 DE [subseq from] '[Human Gut Community Subject 8]' #=GS ECI38892.1/49-119 DE [subseq from] hypothetical protein GOS_4987293 [marine metagenome] #=GS EBO36809.1/78-128 DE [subseq from] hypothetical protein GOS_8092164 [marine metagenome] #=GS EDJ55276.1/128-205 DE [subseq from] hypothetical protein GOS_1675367 [marine metagenome] #=GS ECO20665.1/121-161 DE [subseq from] hypothetical protein GOS_6394916 [marine metagenome] #=GS EBF22566.1/49-117 DE [subseq from] hypothetical protein GOS_9632562 [marine metagenome] #=GS EBP01945.1/23-74 DE [subseq from] hypothetical protein GOS_7981119 [marine metagenome] ECH76192.1/30-99 ---QQSPLAGFQYY....DGk.....vvWDNMRVG.DAL..TLVREPQNPHDSNAVRVD-WKGQ....PL.GYVPRRDNRDVA.RQI...DR..G.AL--...----------...------------- EBO63721.1/52-142 ------PLAGFSHH....EGr.....alWTGLSRG.DTL..ALVREADNPHDANAVAVL-WRGH....KL.GYVPRTQNTALA.WAM...DR..G.ETISariSALRMERNP-...RKRIEFEVFV--- EBX73920.1/12-93 ----HCFIAGLQYY....DVl.....eiWKCLKIG.DQV..ELIPEPENGYDKNAVMVV-YKGT....QL.GYLPRSENRHIA.KIL...NA..G.LNPY...EARIQSLYQ-...DK----------- 2000412030/34-123 -------LAGSQFY....AVg.....evWPQIRLG.DRL..TLIREPENRHDRKAVRVE-WQGR....QL.GYVPRAENRAVA.RAL...DD..-.GEKL...EARVSRLREDpdpWRRVEFEVFL--- 2000115980/34-123 -------LAGSQFY....AVa.....evWPQIRLG.DRL..TLIREPENRHDRKAVRVE-WQGR....QL.GYVPRAENRAVA.RAL...DD..-.GEKL...EARVSRLREDpdpWRRVEFEVFL--- 2000178390/34-123 -------LAGSQFY....AVa.....evWPQIRLG.DRL..TLIREPENRHDRKAVRVE-WQGR....QL.GYVPRAENRAVA.RAL...DD..-.GEKL...EARVSRLREDpdpWRRVEFEVFL--- 2001020610/34-123 -------LAGSQFY....AVa.....evWPQIRLG.DRL..TLIREPENRHDRKAVRVE-WQGR....QL.GYVPRAENRAVA.RAL...DD..-.GEKL...EARVSRLREDpdpWRRVEFEVFL--- EBG54264.1/14-92 ------YIAGLSYY....DGa.....eaFSQLEIG.STI..SLLIEEDNFYDENAVVLY-YENY....KL.GYVPKESNKSLS.KIL...KA..G.YDVF...TGIVQQVDSS...------------- 2004004918/10-91 ----SFHIAGFQYA....DGa.....lvLGDLKVG.DKL..TLCAERDNPHDPEAVAIY-CGNT....KL.GYVPGNEVGPLS.LMM...YY..G.HEDV..fEARVQQVAPE...------------- 2004002365/15-107 ----SFHVAGFQHW....DGa.....tvLSKLSPG.CQL..DLVPEFDNPHDPEAIALY-IDGV....KI.GYVPADKNGLIS.TLAffgHT..G.VFEC...RVLQVAPEKD..pWEQVRVGI----- 2004040867/10-91 ----SFHIAGFQYA....DGa.....lvLGDLKAG.DKL..TLCAERDNPHDPEAVAIY-YGKT....KL.GYVPGNEVGPLS.LMM...YY..G.HEDV..fEARVQQVAPE...------------- EBF88537.1/5-111 -GSFSQEVVGESFY....KDsfktirayVEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAEIVQ.GQL..nDL.gG.SAKV...TGRFHFGKHN...SVRLDMKIPLEIK 2004040927/3-55 --KVYVTITGMKYY....YG........FNPFSIG.KKL..TCKKEHNNPYDSEAIKVTMKNIG....TV.GYIA--------.---...--..-.----...----------...------------- 2004006303/10-64 ----SFHIAGFQYA....DGa.....lvLGDLKAG.DKL..TLCAERDNPHDPEAVAIY-YGKT....KL.GYVPGN------.---...--..-.----...----------...------------- EBF20242.1/61-120 --------------....--........---IAIG.DPL..TLQHEPENQWDANAVKVF-WKDQ....WI.GYLPKDMAALVA.AEV...PD..A.AQGL...EAVVTGL---...------------- EBF20506.1/61-120 --------------....--........---IAIG.DPL..TLQHEPENQWDANAVKVF-WKDQ....WI.GYLPKDMAALVA.AEV...PD..A.AQGL...EAVVTGL---...------------- EBF32622.1/49-152 -GSFSQEVVGESFY....KDsfktirayIEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAEIVQgQLI...DL..GgGAKV...TGRFHFGKHN...SVRLDMNIPL--- EBF70672.1/92-137 --------------....--........----AIG.DPL..TLQHEPENQWDANAVKVC-WKDQ....WI.GYLPKDMAALVA.AEV...P-..-.----...----------...------------- ECW15383.1/30-98 --------------....--........-------.--C..FLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAEIVQ.SQL..nDL.gG.GAKV...TGRFHFGKHN...SVRLDMKIPL--- ECW09508.1/92-149 --------------....--........----AIG.DPL..TLQHEPENQWDANAVKVF-WKDQ....WI.GYLPKDMAALVA.AEV...PD..A.AQGL...EAVVTG----...------------- EBF76019.1/54-152 ------EVVGESFY....KDsyktirayVEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAEIVQ.GQL..nDL.gG.SAKV...TGRFHFGKHN...SVRLDMKIPL--- EDJ05484.1/54-152 ------EVVGESFY....KDsyktirayVEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAEIVQ.GQL..nDL.gG.SAKV...TGRFHFGKHN...SVRLDMKIPL--- EBF14316.1/49-151 -GSFSQEVVGESFY....KDsfktirayIEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAEIVR.GQL...NNlgG.SAKV...TGRFHFGKHN...SVRLDMKIP---- 2001253010/136-207 ----EFRIAGSPHY....EA........IKRLAVG.DDL..RLERDTPNAYDVHASWVLNLGSE....RL.GHVPRPYSKLLA.KHI...DL..-.AHQL...EARA------...------------- 2004037144/89-138 -----FTITGINYY....KN........DVQFNPG.LPL..KLVKEPDNEFDKDAIAVY-VEDK....KI.GYVAN-------.---...--..-.----...----------...------------- 2004003858/90-139 -----FTITGINYY....KN........DVQFNPG.LPL..KLVKEPDNEFDKDAIAVY-VEDK....KI.GYVAN-------.---...--..-.----...----------...------------- 2004040902/57-117 --------------....--........-RYNPET.VSF..ILNRESDNQYDRNAIAVYASVGSgkayKM.GYISAAVACLLS.GII...DN..-.ITTV...NA--------...------------- 2000336500/4-65 --------------....--........-------.---..------ETRHDRKPVRVE-WQGR....QL.GYVPRAENRAVA.RAL...DD..-.GEKL...EARVSRLREDpdpWRRVEFEVFL--- 2004029763/203-252 -----FTITGINYY....KN........DVQFNPG.LPL..KLVKEPDNEFDKDAIAVY-VEDK....KI.GYVAN-------.---...--..-.----...----------...------------- ECI38892.1/49-119 -GSFSQEVVGESFY....KDsfktirayIEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGVL....QV.GHIPREVAEIV-.---...--..-.----...----------...------------- EBO36809.1/78-128 --------------....--........-------.TSA..MLELEPTNDFDPNAVKVM-VNGL....QV.GYVPKTFSGDVM.RMM..nDK..G.VTEF...E---------...------------- EDJ55276.1/128-205 ------FARGLRHLgaadQA.......rAAKLAPG.ERL..YLLKDVQSTHDAMALVLRTEDPL....SLvGYVPRYHCADLS.KLL...EL..G.GAET...VTVTA-----...------------- ECO20665.1/121-161 -GTMPVLIVGCQYY....VG........--VIHAG.ELA..NLVREPHNQYDKNAIRVD-----....--.------------.---...--..-.----...----------...------------- EBF22566.1/49-117 -GSFSQEVVGESFY....KDsyktirahIEQNHPGeDEVvcFLVADPSNRFDKNAVRVM-AGDL....QV.GHIPREVAE---.---...--..-.----...----------...------------- EBP01945.1/23-74 -----FKIAGISNY....EE.......nAKTIGYD.TIL..EMEHEPNNPYDSSAIKIK-NKDK....MI.GYVPNN------.---...--..-.----...----------...------------- #=GC PP_cons .7887888899999....77........8888899.999..999****************8889....**.****9******9.999...77..6.6677...7777777777...7788877776875 #=GC RF xxxxxxxxxxxxxx....xx........xxxxxxx.xxx..xxxxxxxxxxxxxxxxxxxxxxx....xx.xxxxxxxxxxxx.xxx...xx..x.xxxx...xxxxxxxxxx...xxxxxxxxxxxxx //