Summary: Toxin SymE, type I toxin-antitoxin system
This is the Wikipedia entry entitled "SymR RNA". More...
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Toxin SymE, type I toxin-antitoxin system Provide feedback
SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin [1,2].
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR014944
This entry represents a SOS-induced gene whose product shows homology to the antitoxin MazE (SymE), the coding region contains a cis-encoded antisense RNA. The small antisense RNA and the gene have the all the hallmarks of a toxin-antitoxin module. The synthesis of the SymE is tightly repressed at multiple levels; at the transcriptional level by the LexA repressor, at the level of mRNA stability and translation by the SymR RNA and at the level of protein stability by the Lon protease. SymE co-purifies with ribosomes and overproduction of the protein leads to cell growth inhibition, decreased protein synthesis and increased RNA degradation. These properties are shared with several RNA endonuclease toxins of toxin-antitoxin modules. It seems probable that the SymE protein represents an evolutionary derivative of a toxin containing the AbrB fold, whose representatives are typically antitoxins. The SymE promoted cleavage of RNA cleavage may be important for the recycling of RNAs damaged under SOS-inducing conditions [PUBMED:17462020].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||cytoplasm (GO:0005737)|
|Molecular function||RNA binding (GO:0003723)|
|hydrolase activity, acting on ester bonds (GO:0016788)|
|Biological process||RNA metabolic process (GO:0016070)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
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EGFdomains, and finally a single
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This superfamily includes the DNA-binding domain of AbrB as well as the presumed DNA-binding protein MraZ (per. comm. A Andreeva and A Murzin).
The clan contains the following 3 members:Antitoxin-MazE MraZ SymE_toxin
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||PSI2 target AAC77303.1|
|Author:||Bateman A, Eberhardt R|
|Number in seed:||23|
|Number in full:||839|
|Average length of the domain:||49.20 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||50.52 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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