Summary: Stannin unstructured linker
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Stannin unstructured linker Provide feedback
Members of this family are unstructured, acting as connectors of the stannin helical domains. They contain a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade .
Buck-Koehntop BA, Mascioni A, Buffy JJ, Veglia G; , J Mol Biol. 2005;354:652-665.: Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. PUBMED:16246365 EPMC:16246365
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015136
This entry represents an unstructured protein region which connects two adjacent stannin helical domains. It contains a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade [PUBMED:16246365].
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Curation and family details
|Author:||Mistry J, Sammut SJ|
|Number in seed:||3|
|Number in full:||39|
|Average length of the domain:||26.00 aa|
|Average identity of full alignment:||95 %|
|Average coverage of the sequence by the domain:||29.68 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SNN_linker domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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