Summary: Mitochondrial matrix Mmp37
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MMp37 is a mitochondrial matrix protein that functions in the translocation of proteins across the mitochondrial inner membrane . It has been shown that MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane .
Gallas MR, Dienhart MK, Stuart RA, Long RM; , Mol Biol Cell. 2006; [Epub ahead of print]: Characterization of Mmp37p, a Saccharomyces cerevisiae Mitochondrial Matrix Protein with a Role in Mitochondrial Protein Import. PUBMED:16790493 EPMC:16790493
Kuchta K, Knizewski L, Wyrwicz LS, Rychlewski L, Ginalski K;, Nucleic Acids Res. 2009; [Epub ahead of print]: Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human. PUBMED:19833706 EPMC:19833706
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This clan contains a diverse set of nucleotidyltransferase enzymes.
The clan contains the following 22 members:Adenyl_cycl_N Adenyl_transf Aminoglyc_resit DNA_pol_B_palm DUF1693 DUF1814 DUF2204 DUF294 DUF925 DZF GlnE GrpB LicD Mab-21 MdcG Mmp37 NTP_transf_2 NTP_transf_5 Nuc-transf PolyA_pol Pox_polyA_pol RelA_SpoT
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Curation and family details
|Seed source:||Pfam-B_15301 (release 20.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||24|
|Number in full:||355|
|Average length of the domain:||275.80 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||80.49 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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