# STOCKHOLM 1.0
#=GF ID   BRCA-2_helical
#=GF AC   PF09169.11
#=GF DE   BRCA2, helical
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1iyj
#=GF GA   25.00 25.00;
#=GF TC   25.10 25.00;
#=GF NC   24.90 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cut_ga HMM metaseq
#=GF TP   Domain
#=GF WK   BRCA2
#=GF RN   [1]
#=GF RM   12228710
#=GF RT   BRCA2 function in DNA binding and recombination from a
#=GF RT   BRCA2-DSS1-ssDNA structure. 
#=GF RA   Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng
#=GF RA   N, Chen PL, Lee WH, Pavletich NP; 
#=GF RL   Science 2002;297:1837-1848.
#=GF DR   INTERPRO; IPR015252;
#=GF DR   SCOP; 1iyj; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family adopt a helical structure, consisting of
#=GF CC   a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10)
#=GF CC   and two successive beta-hairpins (beta 1 to beta 4). An approx.
#=GF CC   50-amino acid segment that contains four short helices (alpha 2
#=GF CC   to alpha 4), meanders around the surface of the core structure.
#=GF CC   In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1
#=GF CC   (Pfam:PF09103) through van der Waals contacts involving
#=GF CC   hydrophobic and aromatic residues, and also through side-chain
#=GF CC   and backbone hydrogen bonds. The domain binds the 70-amino acid
#=GF CC   DSS1 (deleted in split-hand/split foot syndrome) protein, which
#=GF CC   was originally identified as one of three genes that map to a
#=GF CC   1.5-Mb locus deleted in an inherited developmental malformation
#=GF CC   syndrome [1].
#=GF SQ   1
#=GS ECQ78456.1/144-193 DE [subseq from] hypothetical protein GOS_4284179 [marine metagenome]
ECQ78456.1/144-193         --------------------------------------------------------------------------------------------------------------------------------------IDDQWVRNHYRWIVWKLASYERRLGKTFRG-ALSFREVLRQLRHRRDRELE--
#=GC PP_cons               ......................................................................................................................................789***************************.9**************99976..
#=GC RF                    xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
//