Summary: Taq polymerase, exonuclease
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Taq polymerase, exonuclease Provide feedback
Members of this family are found in prokaryotic Taq DNA polymerase, where they assume a ribonuclease H-like motif. The domain confers 5'-3' exonuclease activity to the polymerase .
Li Y, Mitaxov V, Waksman G; , Proc Natl Acad Sci U S A. 1999;96:9491-9496.: Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation. PUBMED:10449720 EPMC:10449720
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015361
This domain is found in prokaryotic Taq DNA polymerase (thermostable), where it assumes a ribonuclease H-like motif. The domain confers 5'-3' exonuclease activity to the polymerase [PUBMED:10449720].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||DNA-directed DNA polymerase activity (GO:0003887)|
|nucleoside binding (GO:0001882)|
|Biological process||DNA repair (GO:0006281)|
|DNA replication (GO:0006260)|
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Curation and family details
|Number in seed:||4|
|Number in full:||36|
|Average length of the domain:||130.30 aa|
|Average identity of full alignment:||60 %|
|Average coverage of the sequence by the domain:||15.85 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Taq-exonuc domain has been found. There are 37 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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