Summary: Endonuclease VIII-like 1, DNA bind
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Endonuclease VIII-like 1, DNA bind Provide feedback
Members of this family are predominantly found in Endonuclease VIII-like 1 and adopt a glucocorticoid receptor-like fold. They allow for DNA binding .
Doublie S, Bandaru V, Bond JP, Wallace SS; , Proc Natl Acad Sci U S A. 2004;101:10284-10289.: The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. PUBMED:15232006 EPMC:15232006
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR015371
This domain is predominantly found in Endonuclease VIII-like 1 proteins and adopts a glucocorticoid receptor-like fold. Structural analysis reveals a zincless finger motif that is required for glycosylase activity [PUBMED:15232006].
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Curation and family details
|Number in seed:||6|
|Number in full:||57|
|Average length of the domain:||38.60 aa|
|Average identity of full alignment:||70 %|
|Average coverage of the sequence by the domain:||10.96 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Neil1-DNA_bind domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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