Summary: Interferon-alpha/beta receptor, fibronectin type III
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Interferon-alpha/beta receptor, fibronectin type III Provide feedback
Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha [1].
Literature references
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Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J; , Structure. 2003;11:791-802.: The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. PUBMED:12842042 EPMC:12842042
Internal database links
SCOOP: | fn3 IFNGR1 Pur_ac_phosph_N |
Similarity to PfamA using HHSearch: | fn3 |
External database links
SCOP: | 1n6u |
This tab holds annotation information from the InterPro database.
InterPro entry IPR015373
Proteins with this domains have a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They include interferon receptors, tissue factor proteins and interleukin receptors.
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan E-set (CL0159), which has the following description:
This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.
The clan contains the following 93 members:
A2M A2M_N A2M_N_2 AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Arch_flagellin Arylsulfotran_N Big_1 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_5 Big_4 Big_5 BiPBP_C BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_pro Calx-beta CARDB CBM39 CBM_X2 CelD_N CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N CHU_C Coatamer_beta_C COP-gamma_platf CopC DUF11 DUF1410 DUF2271 DUF3244 DUF4165 DUF4625 DUF5011 DUF916 EpoR_lig-bind Filamin FixG_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 Fn3_assoc GBS_Bsp-like Glyco_hydro_61 He_PIG HYR IFNGR1 IL12p40_C IL17R_fnIII_D2 IL4Ra_N IL6Ra-bind Integrin_alpha2 Interfer-bind Invasin_D3 LEA_2 Lep_receptor_Ig LPMO_10 LRR_adjacent MG1 Mo-co_dimer Neurexophilin NPCBM_assoc PhoD_N PKD PKD_2 PKD_3 Pur_ac_phosph_N Qn_am_d_aIII REJ RHD_dimer Rib SoxZ SprB SVA SWM_repeat T2SS-T3SS_pil_N TcfC TIG Tissue_fac Transglut_C TRAP_beta Y_Y_YAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (37) |
Full (1045) |
Representative proteomes | UniProt (1579) |
NCBI (4546) |
Meta (23) |
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RP15 (114) |
RP35 (274) |
RP55 (687) |
RP75 (960) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
not generated,
— not available.
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Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (37) |
Full (1045) |
Representative proteomes | UniProt (1579) |
NCBI (4546) |
Meta (23) |
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---|---|---|---|---|---|---|---|---|---|
RP15 (114) |
RP35 (274) |
RP55 (687) |
RP75 (960) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | pdb_1n6u |
Previous IDs: | none |
Type: | Domain |
Author: | Sammut SJ |
Number in seed: | 37 |
Number in full: | 1045 |
Average length of the domain: | 100.40 aa |
Average identity of full alignment: | 21 % |
Average coverage of the sequence by the domain: | 29.59 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 104 | ||||||||||||
Family (HMM) version: | 9 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Colour assignments
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Selections
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
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Interactions
There are 10 interactions for this family. More...
IL22 IL10 EGF Tissue_fac Interferon Interferon Interfer-bind EGF Tissue_fac GlaStructures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Interfer-bind domain has been found. There are 89 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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