Summary: UTP15 C terminal
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UTP15 C terminal Provide feedback
U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA . It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs) . This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (PF00400).
Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ; , Nature 2002;0:0-0.: A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. PUBMED:12068309 EPMC:12068309
Gallagher JE, Dunbar DA, Granneman S, Mitchell BM, Osheim Y, Beyer AL, Baserga SJ;, Genes Dev. 2004;18:2506-2517.: RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. PUBMED:15489292 EPMC:15489292
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018983
This entry represents the C-terminal domain of the U3 small nucleolar RNA-associated protein 15 (UTP15). This protein is involved in nucleolar processing of pre-18S ribosomal RNA, and is required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). UTP15 is a component of the ribosomal small subunit (SSU) processome, which is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome [PUBMED:15590835, PUBMED:15489292]. This domain is found C-terminal to the WD40 repeat (INTERPRO). UTP15 associates with U3 snoRNA, which is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA [PUBMED:12068309].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||nucleolus (GO:0005730)|
|Biological process||rRNA processing (GO:0006364)|
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|Seed source:||Pfam-B_7112 (release 21.0)|
|Author:||Mistry J, Wood V|
|Number in seed:||40|
|Number in full:||321|
|Average length of the domain:||147.80 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||28.41 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
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