Summary: SSXRD motif
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SSXRD motif Provide feedback
SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localise to this region .
Lim FL, Soulez M, Koczan D, Thiesen HJ, Knight JC; , Oncogene. 1998;17:2013-2018.: A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas. PUBMED:9788446 EPMC:9788446
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019041
Protein SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N terminus. However, from the analysis of these deletion constructs further repression activity was found at the C terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localise to this region [PUBMED:9788446].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||nucleus (GO:0005634)|
|Molecular function||nucleic acid binding (GO:0003676)|
|Biological process||regulation of transcription, DNA-dependent (GO:0006355)|
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Curation and family details
|Seed source:||Pfam-B_23332 (Release 21.0)|
|Number in seed:||33|
|Number in full:||133|
|Average length of the domain:||32.80 aa|
|Average identity of full alignment:||56 %|
|Average coverage of the sequence by the domain:||11.21 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
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