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1  structure 898  species 0  interactions 1132  sequences 14  architectures

Family: CHZ (PF09649)

Summary: Histone chaperone domain CHZ

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Histone chaperone domain CHZ Provide feedback

This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones [1].

Literature references

  1. Luk E, Vu ND, Patteson K, Mizuguchi G, Wu WH, Ranjan A, Backus J, Sen S, Lewis M, Bai Y, Wu C; , Mol Cell. 2007;25:357-368.: Chz1, a nuclear chaperone for histone H2AZ. PUBMED:17289584 EPMC:17289584


This tab holds annotation information from the InterPro database.

InterPro entry IPR019098

This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones [ PUBMED:17289584 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(47)
Full
(1132)
Representative proteomes UniProt
(1648)
RP15
(142)
RP35
(460)
RP55
(793)
RP75
(1158)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(47)
Full
(1132)
Representative proteomes UniProt
(1648)
RP15
(142)
RP35
(460)
RP55
(793)
RP75
(1158)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(47)
Full
(1132)
Representative proteomes UniProt
(1648)
RP15
(142)
RP35
(460)
RP55
(793)
RP75
(1158)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Wood V
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Wood V , Coggill P
Number in seed: 47
Number in full: 1132
Average length of the domain: 33 aa
Average identity of full alignment: 40 %
Average coverage of the sequence by the domain: 12.26 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.3 23.3
Trusted cut-off 23.3 23.3
Noise cut-off 23.2 23.2
Model length: 34
Family (HMM) version: 13
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CHZ domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0D2DP93 View 3D Structure Click here
A0A1C1CV93 View 3D Structure Click here
A0A1D6F6G2 View 3D Structure Click here
A1CQS5 View 3D Structure Click here
A1D3N8 View 3D Structure Click here
A2QPM6 View 3D Structure Click here
A3LXX5 View 3D Structure Click here
A4QYF9 View 3D Structure Click here
A5DLG8 View 3D Structure Click here
A5E145 View 3D Structure Click here
A7ER98 View 3D Structure Click here
A7TR90 View 3D Structure Click here
A8N7N4 View 3D Structure Click here
B0D1Q8 View 3D Structure Click here
C0NYC7 View 3D Structure Click here
C1HB64 View 3D Structure Click here
E9PSX7 View 3D Structure Click here
F1R9K1 View 3D Structure Click here
I1KA89 View 3D Structure Click here
K7KM74 View 3D Structure Click here
P40019 View 3D Structure Click here
Q0C807 View 3D Structure Click here
Q0V3E0 View 3D Structure Click here
Q10239 View 3D Structure Click here
Q1E4L8 View 3D Structure Click here
Q2GNS7 View 3D Structure Click here
Q2R2Z3 View 3D Structure Click here
Q2UBH8 View 3D Structure Click here
Q4WJ31 View 3D Structure Click here
Q59RN6 View 3D Structure Click here
Q5B2V2 View 3D Structure Click here
Q5Q0F0 View 3D Structure Click here
Q6CWY0 View 3D Structure Click here
Q6FWW0 View 3D Structure Click here
Q755T5 View 3D Structure Click here
Q8BLH7 View 3D Structure Click here
Q9BW71 View 3D Structure Click here
Q9P534 View 3D Structure Click here
Q9SUE9 View 3D Structure Click here
U7PZ61 View 3D Structure Click here