Summary: Cortactin-binding protein-2
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Cortactin-binding protein-2 Provide feedback
This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains PF00023 towards the C-terminus which act as protein-protein interaction domains .
Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW; , Genomics. 2001;78:7-11.: Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31. PUBMED:11707066 EPMC:11707066
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019131
This entry represents a N-terminal domain found in cortactin-binding protein 2 and in filamin A interacting protein 1 (Filip1).
In addition to being a positional candidate for autism, cortactin-binding protein 2 is expressed at highest levels in the brain in humans. Towards the C-terminal end of this protein are a series of proline-rich regions which are likely to be the points of interaction with the SH3 domain of cortactin. The human protein has six associated ankyrin repeat domains (INTERPRO) towards the C terminus of the protein which act as protein-protein interaction domains [PUBMED:11707066].
Filip1 controls the start of neocortical cell migration from the ventricular zone by acting through a filamin-A/F-actin axis. It may be able to induce the degradation of Filamin A [PUBMED:12055638, PUBMED:15794127].
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Curation and family details
|Seed source:||KOGs (KOG1103)|
|Author:||KOGs, Finn RD, Coggill PC|
|Number in seed:||8|
|Number in full:||414|
|Average length of the domain:||128.90 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||16.96 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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