# STOCKHOLM 1.0
#=GF ID   VEFS-Box
#=GF AC   PF09733.10
#=GF DE   VEFS-Box of polycomb protein
#=GF AU   KOGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   KOGs (KOG2350)
#=GF GA   21.10 21.10;
#=GF TC   21.10 21.40;
#=GF NC   21.00 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11701882
#=GF RT   EMBRYONIC FLOWER2, a novel polycomb group protein homolog,
#=GF RT   mediates shoot development and flowering in Arabidopsis. 
#=GF RA   Yoshida N, Yanai Y, Chen L, Kato Y, Hiratsuka J, Miwa T, Sung
#=GF RA   ZR, Takahashi S; 
#=GF RL   Plant Cell. 2001;13:2471-2481.
#=GF RN   [2]
#=GF RM   11546753
#=GF RT   Su(z)12, a novel Drosophila Polycomb group gene that is
#=GF RT   conserved in vertebrates and plants. 
#=GF RA   Birve A, Sengupta AK, Beuchle D, Larsson J, Kennison JA,
#=GF RA   Rasmuson-Lestander A, Muller J; 
#=GF RL   Development. 2001;128:3371-3379.
#=GF DR   INTERPRO; IPR019135;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal
#=GF CC   region of these proteins, characterised by an acidic cluster and
#=GF CC   a tryptophan/methionine-rich sequence, the acidic-W/M domain
#=GF CC   [1]. Some of these sequences are associated with a zinc-finger
#=GF CC   domain about 100 residues towards the N-terminus. This protein
#=GF CC   is one of the polycomb cluster of proteins which control HOX
#=GF CC   gene transcription as it functions in heterochromatin-mediated
#=GF CC   repression [2].
#=GF SQ   27
#=GS C3XQZ7_BRAFL/403-534  AC C3XQZ7.1
#=GS G3GTR5_CRIGR/7-141    AC G3GTR5.1
#=GS H3CC44_TETNG/513-647  AC H3CC44.1
#=GS SZ12A_DANRE/511-645   AC Q6DC03.1
#=GS G3PQ82_GASAC/509-640  AC G3PQ82.1
#=GS H3D135_TETNG/505-639  AC H3D135.1
#=GS A7S0W2_NEMVE/469-604  AC A7S0W2.1
#=GS H2YZ92_CIOSA/458-584  AC H2YZ92.1
#=GS D0N2Z9_PHYIT/443-573  AC D0N2Z9.1
#=GS D7MCB1_ARALL/11-148   AC D7MCB1.1
#=GS B3H7I2_ARATH/11-152   AC B3H7I2.1
#=GS FIS2C_ARATH/589-726   AC P0DKJ8.1
#=GS M4CM25_BRARP/175-308  AC M4CM25.1
#=GS M4FG70_BRARP/218-355  AC M4FG70.1
#=GS F6I2N5_VITVI/510-647  AC F6I2N5.1
#=GS M0YN29_HORVV/510-646  AC M0YN29.1
#=GS I1HWX9_BRADI/493-630  AC I1HWX9.1
#=GS J3LVK1_ORYBR/474-611  AC J3LVK1.1
#=GS K7LKC9_SOYBN/606-742  AC K7LKC9.1
#=GS K7LIV2_SOYBN/432-569  AC K7LIV2.1
#=GS M4DX32_BRARP/248-385  AC M4DX32.1
#=GS K1QT27_CRAGI/463-596  AC K1QT27.1
#=GS E9FW32_DAPPU/499-625  AC E9FW32.1
#=GS Q16YD4_AEDAE/496-630  AC Q16YD4.1
#=GS SUZ12_DROME/510-644   AC Q9NJG9.1
#=GS T1L2C3_TETUR/463-589  AC T1L2C3.1
#=GS B7QLX9_IXOSC/479-613  AC B7QLX9.1
C3XQZ7_BRAFL/403-534             ..DLELDWTRPFTS.GHNRLYFHSGTCLPLRPQEID..NDSEEESD..PIWLKQRTQHMIDEFTDVNE.GEKELMKMWNLHIMRNGHIADCQVPTACSTFVEEKGVWIVQR.NLVRNMLLHLVNLY..DFSLISSSVVQQTIS...........
G3GTR5_CRIGR/7-141               SEDGEVEQQRTYSS.GHNRLYFHSDTCLPLRPQEME..VDSEDEKD..PEWLREKTITQIEEFSDVNE.GEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKK.NLCRNFMLHLVSMH..DFNLISIMSIDKAVT..........K
H3CC44_TETNG/513-647             TEDGELEQQRTYVS.GHNRLYFHSDSCMPLRPQEMD..LDSEDERD..PEWLREKTATQLDEFTDVNE.GEKEVMKLWNLHVMKHGFIADNQMHQAIMLFTEDRGAHIIRR.NLCRNFLLHLVNMH..DFNLVNTSTIDRAMA..........R
SZ12A_DANRE/511-645              PEDGEQEQQRTYIS.GHNRLYFHSDSCTPLRPQEME..VDSEDERD..PDWLREKTAMQIEEFTDVNE.GEKEIMKLWNLLVMKHGFIADNQMNQACMSFVEQHGTIMVEK.NLCRNALLHLINMH..DFGLITTATIDKAMT..........H
G3PQ82_GASAC/509-640             .EDGDQEQ..PIVS.GHNRLYFHSDSCVPLRPQEME..VDSEDERD..PDWLKEKTAMQIEDFTDVNE.GEKEIMKLWNLHVMKHGFIADNQMNESCLRFADHHGVHIVRN.DLCRNFLLHLISMH..DFNLVTTQTIDQAMA..........R
H3D135_TETNG/505-639             SEDGEREQQRTYIS.GHNRLYFHSDSCVPLRPQEMD..VDSEDERD..PAWLKEKTSKQIEEFTDVNE.GEKEIMKLWNLHVMKRGFIADNQMNEACLLFAEHHGAHIVQN.NLCRNLLLHLISMH..DFNLINTLTIDRAMA..........R
A7S0W2_NEMVE/469-604             .EPDDADENRPYHS.GYTRTYFHSSTCVPISQSELGSLSDSEGEEN..PLWMRMRTIQMIDDFTDVND.GEKELMKLWNLHLMEKGYVADAQVYSACLTFIDVNAKKIMSQ.NLKRNFLIHLVSLH..DFNLLNGGQIFQLMQ..........K
H2YZ92_CIOSA/458-584             KEENEASPAAHYAA.GHHRLYFHSETVVPVRPCEFD..MDSEEETD..PEWLRAHTTKMLDEFTDVND.GEKPIMKLWNLYVMKHNCIADAQLATTCREFLDVHAALIVKH.NLRRNLLLHFVTLV..DFGVLKAS..................
D0N2Z9_PHYIT/443-573             ....SQEQPQEFYAPLLQRQYFHSRTGAVVLDHEKD..YDSDDDVD..ETWITKQSERLLDEFEDVSL.EEKEFMKKWNRHVKESKILADFMVASSCRMFARNHGRWLLDH.GLRHNFLLHLLNLW..DNSLLNSRAIIDCML...........
D7MCB1_ARALL/11-148              MVPAKRSKARSHYLTLPKRQFYNTRTGQPLSLEEVMSDRDNENDVD..DVAEHLAESQMPNDSMDENEIVAERFIHLWNSFVKKQRIVADYHIPWACEAFSRLHLQELRSNLSL..............DLGNKETTETGMCRNGEKDGMDVGEE
B3H7I2_ARATH/11-152              KVPAKRSKATSHYLPLHKRQFYHSRTGQPLSLEQVMSDRDSENDVDKNDDAAHLEESQMLNGSMDENEIVAERFIKLWNSFVKQQRIVADAHIPWACEAFSRLHLQELRSNLSLDLCWRQFMIKQW..DYGLLDRVTMNKCNT..........I
FIS2C_ARATH/589-726              ELHAERCEAKRLER.LKGRQFYHSQTMQPITFEQVMSNEDSENETD..DYALDISERLRLERLVGVSK.EEKRYMYLWNIFVRKQRVIADGHVPWACEEFAKLHKEEMKNSSSFDWWWRMFRIKLW..NNGLICAKTFHKCTT..........I
M4CM25_BRARP/175-308             RLEAERTDL......LRSRQFYHSKTLQPMTLEEVLSAADSDNEND..KEFKDFQERMKIDRLVDASD.DEKRFMVLWNTFMDDQSVYADKHVPWACEQFVKHHAKELITP.KLSWQWRMFAIDTLCIKYGLISPKTMDKCSI..........I
M4FG70_BRARP/218-355             KLSEGTSEARRTSL.LQTRQFYHSRTLQPMTLEEVMSDQDSDDEVD..DEVADFEYRHMIDDLEDVSP.TEKDFMHLWKSFVRYQRVITDGQVPWACEAFSKFHKKEFIESKPLHSCWRMFMIKLL..EYGLIDAVTINKCNL..........I
F6I2N5_VITVI/510-647             KLSIERSDPRSRAL.LQKRQFFHSHRAQPMGMEQVLSDRDSEDEVD..DDVADFEDRRMLDDFVDVTK.DEKQLMHLWNSFVRKQRVLADGHIPWACEAFSRLHGHDLAQAPALSWCWRLFMIKLW..NHGLLDARAMNNCNK..........I
M0YN29_HORVV/510-646             KLPVDLDDP.SLVL.LKKREFFHSQKAQRMEMDVLYSDHDSEDELD..HDIADFEDRTLLNGFSDVAK.EEKRIMHLWNSFKRRQRILADGHIPWACEAFTHQHGQELVQNPRLRWCWRVLMIKLW..NHGLLNGRTMNICNK..........H
I1HWX9_BRADI/493-630             KLSMERADPRNRQL.LQKRQFFHSHRAQPMALEQVFSDRDSEDEVD..DDIADFEDRRMLDDFVDVTQ.DEKLIMHMWNSFVRKQRVLADGHIPWACEGFCQSHGQELVKNPPLLMCWRFFMIKLW..NHSLLDARGMNTCNL..........I
J3LVK1_ORYBR/474-611             KLSANRADPRNRLL.LQKRQFIHSHKAQPMTFEEVLSDNDSEDEVD..DDIADLEDRRMLDDFVDVTK.DEKRIMHMWNSFVRKQSILADSHVPWACEAFSRHHGEELVQNSALLWGWRLFMIKLW..NHSLLDARAMDTCNK..........I
K7LKC9_SOYBN/606-742             KLPIEQYDPRIVAR.FEKRQFYHSHKYQPMALEEALLDEDSEDEMN..EGAQEIEDRRRL.AILDAPD.HVKEFLSLWNAFIKKHRVLADGHINWACEAFTKYHSAEFAQSNSLAWNWRMFMIKLI..NQGLLKTSTFVACNN..........I
K7LIV2_SOYBN/432-569             KLSIERPDPRNSTL.LRKRQFFHSHKAQPMAIEQVVSDKDSEDEVD..DDVADFEDRRMLENFVDVSK.DEKSLMHMWNSFVRKHRVIADGHISWACEAFSKLHAPEFVQSPSLAGCWRIFMVKLY..NHGLLDARTMNDCNI..........I
M4DX32_BRARP/248-385             KLSAERSEARSNLL.LQKRQFYHSHRVQPMSLEQVMSDRDSEDEVD..DDVADLEDRQMLDDFVDVNK.NEKRFMHLWNSFVRKQRVVADGHIPWACEAFSKFHKEELLHSSPLFWCWRLFMIKLW..NIGLVDSATINNCNI..........I
K1QT27_CRAGI/463-596             .AENDIQINRQFMQ.GHNRLYYHTLTSEVIRPQEID..VDSEEETD..PLWLRQKTVNMIDEFTDVNE.GEKELMKLWNLHVMKYNFIADCQIPEACYTFVNEHGEAMVKK.NLAKNFLIHMVNLF..DFSLIRPDVVHKTMR..........M
E9FW32_DAPPU/499-625             ......ETQRPFIT.GHNRLYHHTSTCLPIQAKELD..VDSENETD..PEWLRAKTCMMIDEFTDVNE.GEKELMKLWNLHVLKHNYVGDCQMGVALQMFLDNHGQELLKR.NLYRNFILHLSNLY..DFGIIAPATVLRTI............
Q16YD4_AEDAE/496-630             CDENEFDSQRPFIT.GHSRMYHHTMTCLPVHPKELD..IDSEGESD..PLWLQHKTMQMIDEFTDVNE.GEKELMKMWNLHVMKYGYVGDCQIPVALDMFIDCRGRDLLRK.NLYRNFILHVCSMF..DFGLVSPEVMQNAIR..........K
SUZ12_DROME/510-644              LDEDEISNQRSYIT.GHNRLYHHTETCLPVHPKELD..IDSEGESD..PLWLRQKTIQMIDEFSDVNE.GEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRK.NLYRNFILHMCSLF..DYGLIAAETVYKTVQ..........K
T1L2C3_TETUR/463-589             .......SIRPYIR.GHNRQYYQSTDCFPIKPQEID..EDSEAEID..PEWMRIKTQLMIDEFTDVNE.GEKEVMKLWNLHGMKHGYVGDCQIPAACEKFVDQYWQEIFNR.GLYKNFILHLNNLF..DFGILPATHMRSVIK...........
B7QLX9_IXOSC/479-613             QDEVDIDLPRPYIS.GHNRLYYHTETCLPIRPQEID..RDSESEDD..PDWLRIKTQLMIDEFTDVNE.GEKELMKMWNLHIMKHGFVGDCQIALACNLFVEQQGEVLMQR.NLYRNFVLHMCNLL..DFGLVSTSVVYTTVR..........R
#=GC seq_cons                    p.ss-tspsRshht.h+pR.aaHScos.Plp.pEl...hDSE-EsD..s-hhchcsppMlD-FsDVN-.sEKclM+LWNhaVhKpthlADsplshACctFsctHupcllpp.sLttsahlahlpLa..DaGLlsspshpps.t..........h
//