Summary: Exocyst complex component Sec3
Exocyst complex component Sec3 Provide feedback
This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.
Internal database links
|SCOOP:||DUF2443 ALIX_LYPXL_bnd Sec3_C_2 TBCC_N NBD94|
|Similarity to PfamA using HHSearch:||Vps52|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019160
The exocyst complex is composed of 8 subunits: Exoc1, Exoc2, Exoc3, Exoc4, Exoc5, Exoc6, Exoc7 and Exoc8. This entry represents the subunit Exoc1 (Sec3).
Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein [PUBMED:16181645].
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This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
The clan contains the following 17 members:COG2 COG5 COG6 Dor1 DUF2450 Exo70 Exo84_C Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Zw10
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Curation and family details
|Seed source:||KOGs (KOG2148)|
|Author:||KOGs, Finn RD, Coggill PC|
|Number in seed:||21|
|Number in full:||844|
|Average length of the domain:||470.70 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||59.99 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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