Summary: Guanylylate cyclase
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Guanylylate cyclase Provide feedback
Members of this family of proteins catalyse the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate.
Internal database links
SCOOP: | Peptidase_C39 Peptidase_C39_2 Peptidase_C70 |
Similarity to PfamA using HHSearch: | Peptidase_C39 DUF3335 Peptidase_C70 Peptidase_C39_2 BtrH_N |
This tab holds annotation information from the InterPro database.
InterPro entry IPR018616
GUCD1 contains a guanylyl cyclase domain and is found highly expressed in liver during regeneration [PUBMED:24743017].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan Peptidase_CA (CL0125), which has the following description:
This clan includes peptidases with the papain-like fold.
The clan contains the following 74 members:
Acetyltransf_2 Amidase_5 Amidase_6 BtrH_N CHAP CIF CoV_peptidase DUF1175 DUF1287 DUF1460 DUF2026 DUF2272 DUF3335 DUF553 EDR1 Gln_deamidase_2 Guanylate_cyc_2 Herpes_teg_N Josephin LRAT Mac-1 Menin NLPC_P60 Nt_Gln_amidase OTU Peptidase_C1 Peptidase_C10 Peptidase_C101 Peptidase_C12 Peptidase_C16 Peptidase_C1_2 Peptidase_C2 Peptidase_C21 Peptidase_C23 Peptidase_C27 Peptidase_C28 Peptidase_C31 Peptidase_C32 Peptidase_C33 Peptidase_C34 Peptidase_C36 Peptidase_C39 Peptidase_C39_2 Peptidase_C42 Peptidase_C47 Peptidase_C48 Peptidase_C5 Peptidase_C54 Peptidase_C58 Peptidase_C6 Peptidase_C65 Peptidase_C7 Peptidase_C70 Peptidase_C71 Peptidase_C78 Peptidase_C8 Peptidase_C9 Peptidase_C92 Peptidase_C93 Peptidase_C97 Peptidase_C98 Phytochelatin Rad4 SidE_DUB Tae4 TGase_elicitor Tox-PLDMTX Transglut_core Transglut_core2 Transglut_core3 Transglut_prok UCH UCH_1 VasohibinAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (30) |
Full (700) |
Representative proteomes | UniProt (1085) |
NCBI (1657) |
Meta (9) |
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RP15 (113) |
RP35 (305) |
RP55 (480) |
RP75 (681) |
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Jalview | |||||||||
HTML | |||||||||
PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
not generated,
— not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (30) |
Full (700) |
Representative proteomes | UniProt (1085) |
NCBI (1657) |
Meta (9) |
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---|---|---|---|---|---|---|---|---|---|
RP15 (113) |
RP35 (305) |
RP55 (480) |
RP75 (681) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | KOGs (KOG4621) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
KOGs, Finn RD |
Number in seed: | 30 |
Number in full: | 700 |
Average length of the domain: | 177.40 aa |
Average identity of full alignment: | 42 % |
Average coverage of the sequence by the domain: | 77.07 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 212 | ||||||||||||
Family (HMM) version: | 10 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Selections
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
Tree controls
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