Summary: Biotin-protein ligase, N terminal
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Biotin-protein ligase, N terminal Provide feedback
The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase catalytic domain.
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019197
The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase catalytic domain [PUBMED:18809372]. Biotin protein ligase carries out the post-translational modification of specific proteins by the attachment of biotin. It acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase.
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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Most members of this clan are glutaminase enzymes. This superfamily is shown to be related in . The clan also contains the DJ-1/PfpI family that includes the peptidase PfpI that has a catalytic Cys-His-Glu triad that differs from the class I GAT Cys-His-Glu triad.
The clan contains the following 14 members:BPL_N DJ-1_PfpI DUF4159 GATase GATase1_like GATase_3 GATase_5 Glyco_hydro_42M HTS Peptidase_C26 Peptidase_S51 SNO ThiJ_like ThuA
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||COGs (COG4285)|
|Author:||COGs, Finn RD, Sammut SJ|
|Number in seed:||102|
|Number in full:||823|
|Average length of the domain:||246.90 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||58.30 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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