# STOCKHOLM 1.0
#=GF ID 12TM_1
#=GF AC PF09847.10
#=GF DE Membrane protein of 12 TMs
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF GA 33.2 33.2
#=GF NC 33.1 32.9
#=GF TC 33.6 33.2
#=GF PI DUF2074;
#=GF SE COGs (COG3368)
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF DR INTERPRO; IPR018646;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family carries twelve transmembrane regions. It does not
#=GF CC have any characteristic nucleotide-binding-domains of the
#=GF CC GxSGSGKST type. so it may not be an ATP-binding cassette
#=GF CC transporter. However, it may well be a transporter of some
#=GF CC description.  ABC transporters always have two nucleotide
#=GF CC binding domains; this has two unusual conserved sequence-motifs:
#=GF CC 'KDhKxhhR' and 'LxxLP'.
#=GF SQ 14
Q9HM06.1/17-497      YVNISYGATSFSFIVF.SLILVAPSLMEHRIY........TLSSVV....LLLFVYSLFINI.SNSLLFFVSVninHILD..PLRILPVDFPD..H.VI.AVS...WFIYTGSSSLFAVlpAIFLAAFLLGDPYILVIGL.IWSIFSVLLG.YI...IGSS..IFVAFGSRIS...GKR..TR..STNILRNVGRIVFLVFVFAIFEIILYNANIV...NGIIPRLPYPYSYFIPifniqstvFFFHGIYMQATG...FIISMV....YT.ALASFAFIYVNRKAFY.RL.lEPTARNQSRV.KT..Q..MK......AE.VRSRPFSFFSKDLKISSRKSQ....N....LVLLIMPLFFVFPTIMSEVLYAPTSKad....piiLYNAMVA.FVIVT..SSFYSI.LFLVI..EGNGI......SFIKALPLDGNSIIRWKISAPTFIFAVISISTLAAISVKAL...MG.AAFYI.IIIVDMM.LYFV.SSTVYNMNRLyrk......ipdTADTVNFYSFgGQIAFITTFAFTGLIVGSAD.IFSLFLQDLLRlnayffFLINTVIG.I....IVLLFMVFR
Q8U2D3.1/39-484      NIIWGVFLQSVMYLGL.GVMVAVSILYSENEVqk....aiFFSSYL....IIPFILTLYSTS.LATAYLLSS-...KAVE..PLKPLPLGNLN..F.IV.SLT...LLIENLPAFVFLI..---PASLALGNSIASLLGL.LWICSTILMG.HS...LALF..LQIKFSGIHV...GKG..SV..VKTLVKVAGFLI----IAGIYFIVQALMRILednIEVIAPIFRKYFIAFP........FAASTIYEPYKS...LVLLAL....YT.LPFLALYFYDLKRLGE.VL..-EGIKTYGKV.AT..K..YK......LT.VANPVTAMFRKDYRIIFRKNP....Y....LGTFLSPLLMSIYFIYNLAKEGFPVM.........MTLFSIM.GISVL..GLVMLD.PAFAM..DREVF......PFLSSLPIKRREYLLGKMLTVSLSPLTFSAILVLLSCAFNG...TE.ALLLI.PFLASPF.LTSS.IGILYVKHKM............GNERIELPVL.KFYDGIVMLILSMIPFIIVA.IPLFLLSVPKG......YLVSGAII.L....VGALILSK-
O29855.1/39-477      WIRYNALLLKIMFTFA.ALFSVGPAFFDDKVS........YASSLL....SLFFFFLMFGTA.YAHGYFQVDL...SYMH..TFYSRSDISKV..R.FY.GFF...RLFDWPAVIALLS..---LLVLVGMRNPAGLLPA.LLGFLAVIMGaLS...IVIL..LGKRLGSVQT...GR-..SL..RAAFFRIFGLIAWLVSIYGLYLINQLAI---...YLMTFKNYEAYDSLFP.......iSYGLWISQPFSAk.yAALSLF....YF.ALITLLFFYAVRELSK.E-..-EIAKHYGSL.K-..G..WK......IK.RRGKMTAMVIKDFKQLFRNPQ....L....FVIALLPIYGALM-------------.........QLVFYIK.LSEVA..SVLYLQ.IFLAI..TVSSFmslersSYITALPLTDLEMKFSKILEGLLIYF-VSMGIVAAVVIYKG...GN.LINSL.SLFPTGF.AVVL.VAVQFSRRL-............TSEPVNVE--.AVIATLISFFIVLVPAAVGG.VAVLILKAPFSs...yaFPVSLAET.LavlaVFALLNRRK
O29125.1/31-435      -LRVQVAKSFFIMTFL.GSFLCWVAFISSGLG........-LSLIF....TLSLVFSQIYPA.QNIAISASS-...RVFE..PLRYLPVRFSE..R.ML.VVF...-FIDSINILAFAT..-PTIAVLMVKNLYFGLYSL.LWIIAAILLG.YS...MVFL..YYALFGVKV-...-RS..GF..SKSVL--AGILFFAVLVFAL-----------...-RRFQEIPDLTPYLTP........------------...HLLLLS....Y-.AASSATIKLSTGRVWR.SIlnPEIVEVKGSS.R-..-..--......LS.SGSPLRAMLIKDFRLILRKN-....A....LFPLIVPLVIVMPNVVSIANMPN---.........LSIFIIT.TISTL..STIDLR.IIGNL..ENVDF......--LRMLPLSKRGFVMSKACLIFVISFAASLPAGSIAFIVS-...QN.PFYLF.MAFAIPA.IVSM.LSSLIIFWQ-............KGEEIYFPEV.GFLKWIGLLLVNFGAVYAVL.SPRFILSQPVA......DIISSVLT.L....LAMTALFEK
Q97VM1.1/40-451      -AVTIKISNIIAYTIA.TIVSASISLINKDAP........FSFIFL....DLIILANIFTTG.LNVIFFVTNY...DLKT..FLLSLPLSERD..V.NR.AVF...RGIFEFFYYGFLA..SIVIAPISTYMITSSVLQA.LMAELEIIFF.FS...LSFA..LVMLLGKRI-...-RL..GI..TSALFRIGTSLIWIVFIMLPYGL--------...TFKYVTIPTYILPIFP........FGFLNIEG----...LLISLL....YTgLSVFFAYKQSLKFLSF.RL..------NSQY.ST..K..YS......IK.LRSPLITYLYKDIRGLLRVPQ....A....SFLLTIPVFALIFSFFAPV-------.........YAIFYTI.FMITT..SSIMLI.L---L..EASGM......QLLLSLPAGLRSSYISKLLIILIIYL-------IDVLIFSF..fNR.ASLSL.IMLPSTI.TSVE.LSLFISYNNV...........iKGKGMRLA--.DPLSFIIREIEINSIIGIAS.ILTFFANIYYS......LLFSVLSL.I....MINIVVYKK
B5IFK9.1/41-480      ---KGIGYQFLSYLLF.GLFSGMSIFVISSVD........MISTYVvflsLIPFIFAVFITS.VQGSNVVYM-...GVFE..PLKPLPIKLGS..K.YL.SFY...LLLEILPSLGIVL..-PTSIVISLKYPLPGIISF.LWFFTGIFLG.HI...VGLL..ILILFGLKIK...QRA..GK..SELLISVARAIL-FFLFFGIFYAFVYMQRYImehSGEWVGLIGKYSIMFP........FSSGTIFHPLFS...TVLLIL....YL.ALLGPLYYILILRIWS.RI..MEPRVVFGEKgIR..E..YK......IK.SSSALFTLIGKDMKVLIRRTA....L....LAGFLITLYIVFPQIFMVLSTGKFPI........fNAAIILM.MIGAF..SAGGID.SVLKI..DINAI......EFLRTLPLKKKDFVMGKIISMSVVPWGIGIAILILALYYNG..lYA.LILLP.YVFLLPF.IASS.VVMLYYFHY-............KEEDIGIPDL.KKTDLIILFLILMFIMGIIS.IPLIFHLIWLS......EIVAFG--.-....---------
A0A133VIS3.1/47-494  --VYTNLSLLPAFLTF.SVFLAVPMINSSGSPl......gLFLILL....MIQLFFSAIITL.TSMSNFRSL-...RLQN..PLLSLPIDREI..F.AV.SIS...WIFSGAFPILVVTipAAAAYGWSIGSFIPVIFAL.VWGFLSVFFG.HS...IGLL..LSNIFSFRVSs.nSKL..GK..LSQILKMGGVFL---FLFLWYFV-IYSDRNLgnfFKPLSPLVESLDFIYP........FTASESIVNFSYi.dIFSFFL....YG.MIFIGLYLIVGKKTWN.NL..REPSFRISDK.IE..N..IT......IS.LKGKLLGCIRKDIDLSFRNNH....I....FSVLIFPLMVLLPNLIRVIQGNQLDP.........VTAEVVFlLAGIL..SAMGVV.NFYVG..EGKAA......WIISTLPISKKEFAFQKALAVFLVFPFFAVPIILVISFLIG...LG.IEYLS.LYIASAL.AVAF.TSSIVFSNSLndk......lpeNPVVITQESFgTRLAPILTLLKSAIISIWPV.PLSLLLYYVLNgf..spS-------.-....---------
T0LED0.1/47-504      -VRSSLYVNTIIYAII.SISFGAISTESNASN........NSFILF....LLLLILAIMSDT.Q-FYRGVWDM...KLLT..PLSQLPLKVEK..R.VV.PFS...LFLYNELYLPFVT..--IPAGIVISLEMRSPLPLvVFSLFTVLFI.YVarlVSLL..LGVTFVKTNT...NRR..TK..RLYLGQVFQVVIFVIFILAI-EI---AANPS...FQGFVKIPQFLYYFVP........VASQYISSLSVY..pFASFAL....VF.AVVYPSYLYVQKRSFTeRM..ETFADVTEGA.KK..N..VA......LR.IRKPVRSLMDKDFKVILRRRG....A....IMIMVVPVTFIIPIIPTLLTVSSGTL.........ESVFYIP.YISLV..FLIDFV.LMIGL..EGKAA......WHLSALPITRRQFFFSKLLSIFTIGLVYYGAITAIVGIVNKgmvSYmLFNYP.FFAIILT.AVLF.AGGTYLVNAIpnevytlsqegiGGRWVFMK--.TFIIGLPIIVLNALAFAFAKyIIGFSASYYIR.....gYTLTIAIDaL....VSY------
E0STR5.1/65-451      ----------------.-------RLIETGFDp.....snAFKLFL....TLITGFAVLLVL.LSSATFTSTImreNIID..ILKTLPLRDIDilK.IY.LVA...LILYWGGLSAIFI..YIPFIVGELIAIYSGILSV.EIMLLTILIAiLV...LGTS..YCLGIGLGAY...SHR..GR..YRVSIRALSTSLWIVTAIAFSSIYYLFYNMLi.tIRAIESIAYSWGYLLPiv....giLYSNTVERTIVS...LIITVT....IV.LISIGIAIQNMNRLIY.SE..PIKAIHRKPA.IE..R..FE......LG.IKPILIAAIVKDLKLIGREPRllsaA....LITILIPLVMVIPSAISRVFEIG--Eipfe.gsiiLSSILSI.AIGFM..GSMGID.HFYFS..EGRGS......VLLYYLPISRRMVMLSKALASSAIASPLTAL--ITGIITFL..iTD.SILSA.TAFGLTA.MIIT.IAFSII----............----------.--------------------.-----------......--------.-....---------
A0A2U0RWM2.1/50-484  -----------GFVVA.AVLV---ALFAGNILealgagmfMFQIAI....FLPALMTLASVM.YGLLFEFSQSssvGSSD..VINWLPIHPAE..F.VLaSVF...SMLYFLAPIIGIVfgATLGLALTASMLDVGLFTM.IVSCIGLFLGaFS...LEIIraITNRVSSSVY...KRT..GR..SAIIIRMVVFVL-MFVVYMLLSNVNFLFSILd.qYMNGIQSAWFIPILWPslt..imsYMTTEVLQVIVY...LLLSVV....FT.AALLWAGVKLREKYWV.PA..PFALKVTSTK.DY..A..PKqgilgrFG.FTSAEAALLKKDFRGLTRRKE....M....LVWIAVPIGISVISFFSTPSSLADSAtt....fdrLSLFWGP.LMGLF..MFAFYI.TITSIgqEGSAF......LNLRMIPLNGKEVIRAKLSTALIPSSLAMVVVTVLIQIMLQ...LR.PEALV.ALAVTLFaAVFE.CAFVGVALGC...........rYPDFTEVPRA.RFIDQKGVWL----------.-----------......--------.-....---------
A0A2U0RVN2.1/24-419  ------------FSVLaAVIPFTAQFFGSPVL........GLTSAV....SLSLVVTFGFTAlYAIQTFSSFVs.pESSA..LLSTLPLEQRD..FsLI.TLF...SFVRSVDYIVVGS..-ILSQVILVAYVTASLFAV.LVMLVASVMN.AV...LAVA..AALWFSRMFTnnlSRG..GRskANSVLRLFFILMWGSLLMGVSFLISLPWYIVpslETLLLSSNQLSSVLFCllhpfsvgITIASIGNPVTAgsrALIAAVcmvgYV.VFSGFAASWIIKT-VK.RI..SDGTDVKMSR.VT..AkdFS......VK.TRAPLFGYVLKDLKTASRNPA....T....AFFFALPVLETVIVSFLIANFEVLRAs.......tLLVS-TF.MGGIF..VLIMPL.ALLNA..EGAGL......EYTKTLPLNINRIILSKTLISTLTYVPVPI--VLLVMALL-...-K.PVTSP.LAILIPF.FVISaIA--------............----------.--------------------.-----------......--------.-....---------
A0A328VJ84.1/324-475 ----------------.---------------........------....------------.----------...----..-----------..-.--.---...-------------..-------------------.----------.--...----..----------...---..--..-------------------------------...----------------........------------...------....--.----------------.--..------QGQV.RT..S..WF......ARfLSSQTLAIAAKDLRYFRRDPQ....L....LGQLIMPLVVACVALVAPFLGRNAGRvae...dswFFLFYPP.FIVFLylSMLSIN.-ALGL..ERKPL......TVLLLYPIKPERLFFGKNLAVLVPGL----VLLLAMLAFE-...-S.LFLGL.WHLVLPF.LVAG.LASI------............----------.--------------------.-----------......--------.-....---------
D1CHW3.1/281-437     ----------------.---------------........------....------------.----------...----..-----------..-.--.---...-------------..-------------------.----------.--...----..----------...---..--..-------------------------------...----------------........------------...------....--.----------------.--..---TSTRSHR.SG..R..DR......AG.ARPPWWSLASKDWKELRRDPQ....H....LVGLLYPLVIFGAGVYRSLAVASTRGe.......gWPIFATI.DMGMY..FMIMTL.AQPSInrEGRRL......YLLTLCPLSPREIFVGKWLYAAVPPLALAAALDIAYGLWAG...LH.PLATIyMLLITTL.LAVT.LAG-------............----------.--------------------.-----------......--------.-....---------
A0A448V0I3.1/77-448  ----------------.---------------........--LSVV....DLVLLLLFVLMA.LGTFFQFRDLf.fHSFDenTLWALPIPKES..F.IL.AKFsgsWMTEVPMILAFSV.gSLVLCYLATESLFKVFLLL.LSFLLTTILG.EA...VGGF..LRIAFSRISS...GREmpKF..VKSLI--AVAIFATFMILYYYEIAQEFRHIAe.fSAFYNNLPGPFHLFSYm......lSAHIWVFIPYAL...LAIGIF....YL.------FLTYMGKHFF.EI..AERLEKKGAT.KVigE..DA......FS.PRSKRSALLRKEISLYWSNTA....VamntFFGILVPIILSLLLFVPSLREAFLYFiesqsllprDAFIFLA.AMGFG..GMMNIStFFFSL..EGKNA......YNTYALPLSGREIFLTKLAAGLVLSL-PSLLLSIVLVIIAL..qPA.AAYWP.FLLLAPL.AYAC.LSN-------............----------.--------------------.-----------......--------.-....---------
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