# STOCKHOLM 1.0
#=GF ID 12TM_1
#=GF AC PF09847.10
#=GF DE Membrane protein of 12 TMs
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF GA 33.2 33.2
#=GF NC 33.1 32.9
#=GF TC 33.6 33.2
#=GF PI DUF2074;
#=GF SE COGs (COG3368)
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF DR INTERPRO; IPR018646;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family carries twelve transmembrane regions. It does not
#=GF CC have any characteristic nucleotide-binding-domains of the
#=GF CC GxSGSGKST type. so it may not be an ATP-binding cassette
#=GF CC transporter. However, it may well be a transporter of some
#=GF CC description.  ABC transporters always have two nucleotide
#=GF CC binding domains; this has two unusual conserved sequence-motifs:
#=GF CC 'KDhKxhhR' and 'LxxLP'.
#=GF SQ 27
Q9HM06.1/17-497      YVNISYGATSFSFIVF.SLILVAPSLMEHRIY..........TLS....SVV....LL..LF..VYSLFINI.SNSLLFFVSVninHILD..PLRILPVDFPD..H.VI..AVS...WFIYTGSSSLFAVl..pAIFLAA...F.LL..GDPYI..LVIGL..I.WSIFSVLLG.YI...IGSS..IFVAFGSRIS...G....KR..TR..STN..I..LRNVGRIVFLVFVFAIFEIILYNANIV...........NGIIPRLPYPYSYFIPifniqstvFFFHGIYMQATG....FIIS.MV....YT..ALASFAFI.YVNRKAFY.RL.lEPTARNQSRV.K.T..Q..MK......AE..VRSRPFS....FFSKDLKISSRKSQ....N....LV.LLIMPLFFVFPTI.....MSEVLYAPTSKad....piiLYNAMVA.FVIVT..SSFYSI.LFLVI..EGNGI......SFIKAL...PLDGNSIIRWKISAPTFIFAVISIST...LAAISVKAL...MG.AAFYI.IIIVDMM.LYFV.SSTVYNMNRLyrk......ipdTADTVNFYSFgGQIAFITTFAFTG.LIVGSAD.IFSLFLQDLLRlna.........yffFLINTVIG.I....IVLLFMVFR
Q8U2D3.1/39-484      NIIWGVFLQSVMYLGL.GVMVAVSILYSENEVqk......aiFFS....SYL....II..PF..ILTLYSTS.LATAYLLSS-...KAVE..PLKPLPLGNLN..F.IV..SLT...LLIENLPAFVFLI....---PAS...L.AL..GNSIA..SLLGL..L.WICSTILMG.HS...LALF..LQIKFSGIHV...G....KG..SV..VKT..L..VKVAGFLI----IAGIYFIVQALMRILe........dnIEVIAPIFRKYFIAFP........FAASTIYEPYKS....LVLL.AL....YT..LPFLALYF.YDLKRLGE.VL..-EGIKTYGKV.A.T..K..YK......LT..VANPVTA....MFRKDYRIIFRKNP....Y....LG.TFLSPLLMSIYFI.....YNLAKEGFPVM.........MTLFSIM.GISVL..GLVMLD.PAFAM..DREVF......PFLSSL...PIKRREYLLGKMLTVSLSPLTFSAIL...VLLSCAFNG...TE.ALLLI.PFLASPF.LTSS.IGILYVKHKM............GNERIELPVL.KFYDGIVMLILSM.IPFIIVA.IPLFLLSVPKG...............YLVSGAII.L....VGALILSK-
Q6L2L5.1/39-510      -ILLYYISNSLSFLFF.SIVLNGIYYVKGNTN..........DIS....SFG....II..LF..MYIFVIGI.YSSLTYINGIsinNLLS..PVRSLPIKVNT..D.VP..FLS...WFIYTGSSYIFIIi..pSLLFYY...F.LV..HNLNT..IILGL..I.YAFAMLLFG.FI...ITAI..AFI-----YS...S....RK..PR..AHT..S..LNNFLRILLIFVFLGFFYLIIYDPNILr........aySIYISSLPVYIKYIAFplnidyavYFHPDIIATFFE....YLSS.FI....IL..LIFFFIYK.KIRSRLFY.SL..EYSEEVKSTE.V.T..R..TK......IK..RDSISVS....FIKKDIKITARKSQ....N....LT.YILMPIIFVLPFL.....FTIISSRQPFL........sLMFSILS.LSILI..SSFYPI.FTLII..ENNGI......LIINAL...PINRKDIAKYKAYFSMIFYSIIITVV...SIIIMAYKN...IF.NLYYV.FIIPDLI.LIFY.TAMIINLNRLikk......ipkGASTINYYSF.GVFPTIVLFIVSG.IIFGLLI.SPGIIISEFLYhsi.........kmsFIFDIIPD.L....IIFLIMIKK
O29855.1/39-477      WIRYNALLLKIMFTFA.ALFSVGPAFFDDKVS..........YAS....SLL....SL..FF..FFLMFGTA.YAHGYFQVDL...SYMH..TFYSRSDISKV..R.FY..GFF...RLFDWPAVIALLS....---LLV...L.VG..MRNPA..GLLPA..L.LGFLAVIMGaLS...IVIL..LGKRLGSVQT...G....R-..SL..RAA..F..FRIFGLIAWLVSIYGLYLINQLAI---...........YLMTFKNYEAYDSLFP.......iSYGLWISQPFSAk..yAALS.LF....YF..ALITLLFF.YAVRELSK.E-..-EIAKHYGSL.K.-..G..WK......IK..RRGKMTA....MVIKDFKQLFRNPQ....L....FV.IALLPIYGALM--.....-----------.........QLVFYIK.LSEVA..SVLYLQ.IFLAI..TVSSFmslersSYITAL...PLTDLEMKFSKILEGLLIYF-VSMGI...VAAVVIYKG...GN.LINSL.SLFPTGF.AVVL.VAVQFSRRL-............TSEPVNVE--.AVIATLISFFIVL.VPAAVGG.VAVLILKAPFSs............yaFPVSLAET.LavlaVFALLNRRK
O29125.1/31-435      -LRVQVAKSFFIMTFL.GSFLCWVAFISSGLG..........-LS....LIF....TL..SL..VFSQIYPA.QNIAISASS-...RVFE..PLRYLPVRFSE..R.ML..VVF...-FIDSINILAFAT....-PTIAV...L.MV..KNLYF..GLYSL..L.WIIAAILLG.YS...MVFL..YYALFGVKV-...-....RS..GF..SKS..V..L--AGILFFAVLVFAL-----------...........-RRFQEIPDLTPYLTP........------------....HLLL.LS....Y-..AASSATIK.LSTGRVWR.SIlnPEIVEVKGSS.R.-..-..--......LS..SGSPLRA....MLIKDFRLILRKN-....A....LF.PLIVPLVIVMPNV.....VSIANMPN---.........LSIFIIT.TISTL..STIDLR.IIGNL..ENVDF......--LRML...PLSKRGFVMSKACLIFVISFAASLPA...GSIAFIVS-...QN.PFYLF.MAFAIPA.IVSM.LSSLIIFWQ-............KGEEIYFPEV.GFLKWIGLLLVNF.GAVYAVL.SPRFILSQPVA...............DIISSVLT.L....LAMTALFEK
Q97VM1.1/40-451      -AVTIKISNIIAYTIA.TIVSASISLINKDAP..........FSF....IFL....DL..II..LANIFTTG.LNVIFFVTNY...DLKT..FLLSLPLSERD..V.NR..AVF...RGIFEFFYYGFLA....SIVIAP...I.ST..YMITS..SVLQA..L.MAELEIIFF.FS...LSFA..LVMLLGKRI-...-....RL..GI..TSA..L..FRIGTSLIWIVFIMLPYGL--------...........TFKYVTIPTYILPIFP........FGFLNIEG----....LLIS.LL....YT.gLSVFFAYK.QSLKFLSF.RL..------NSQY.S.T..K..YS......IK..LRSPLIT....YLYKDIRGLLRVPQ....A....SF.LLTIPVFALIFSF.....FAPV-------.........YAIFYTI.FMITT..SSIMLI.L---L..EASGM......QLLLSL...PAGLRSSYISKLLIILIIYL------...-IDVLIFSF..fNR.ASLSL.IMLPSTI.TSVE.LSLFISYNNV...........iKGKGMRLA--.DPLSFIIREIEIN.SIIGIAS.ILTFFANIYYS...............LLFSVLSL.I....MINIVVYKK
B5IFK9.1/41-480      ---KGIGYQFLSYLLF.GLFSGMSIFVISSVD..........MIS....TYVvflsLI..PF..IFAVFITS.VQGSNVVYM-...GVFE..PLKPLPIKLGS..K.YL..SFY...LLLEILPSLGIVL....-PTSIV...I.SL..KYPLP..GIISF..L.WFFTGIFLG.HI...VGLL..ILILFGLKIK...Q....RA..GK..SEL..L..ISVARAIL-FFLFFGIFYAFVYMQRYIm........ehSGEWVGLIGKYSIMFP........FSSGTIFHPLFS....TVLL.IL....YL..ALLGPLYY.ILILRIWS.RI..MEPRVVFGEKgI.R..E..YK......IK..SSSALFT....LIGKDMKVLIRRTA....L....LA.GFLITLYIVFPQI.....FMVLSTGKFPI........fNAAIILM.MIGAF..SAGGID.SVLKI..DINAI......EFLRTL...PLKKKDFVMGKIISMSVVPWGIGIAI...LILALYYNG..lYA.LILLP.YVFLLPF.IASS.VVMLYYFHY-............KEEDIGIPDL.KKTDLIILFLILM.FIMGIIS.IPLIFHLIWLS...............EIVAFG--.-....---------
A0A218ZU73.1/46-498  -IFMNYGFTAVMLIIF.SIVMVFPALFSTSPE.........tAVA....DVG....FV..LF..AYTLSMSI.YNSFIFFNTIgnhRLVE..PLGVLPVKNGD..D.IL..FMS...WLKYNGSSSIFIVv..pVLVLYA...I.KF..SSYET..LFMGS..I.WLLSIIILG.YS...IGAI..IYMSVRKRIS...G....NR..SP..IMS..S..IKGALRMMVIIGIFAMFEIMIYFPGVL...........INYIPRAAGLPGMLVPllnvttvvFQASPVNLNFIS...dIGVT.TF....YL..AVFLVAFS.LIKSRIFT.VL.sNSPDSIPGNR.Q.L..P..VN......LR..VYGFFYS....LFMKDIRGILRKSQ....N....II.LIFLPAIFVLPTIlpllvFGTARNTDVSS.........LYYSLLS.IVIIS..STFYSI.VLMAS..EGNGI......EVINSL...PLSNSDQIISKSVVGIFLFVLIVSPL...TILITALNG...MG.VIVTF.FLLFNII.VAYS.YTSLFNLKWLrgk......isdGTRTINFYSFgGNIVYVLLFIYSL.SLIALSA.MAGNFA-----...............--------.-....---------
T0LBE0.1/41-513      ---------CFFFTLF.SLLISAEYLIDGATG..........FKSftegQIG....FV..IF..LYALVVSA.SSSFFFLSSLnseRLIE..PLTIMPVEISP..F.MI..SIS...WFMFTGSATFFIIf..pPLIISV...F.FF..HNFLS..ILFGF..L.WGGILIFTG.FS...ISSL..IYVFLNSRKS...T....SG..RK..VRS..G..LTNALKLLAFIAVFSIFDLSLYFPQFV...........TYISPNLYGTVKYFIPll...glrYIVFNTNPTFQTilysSIST.GI....YV..LLAFFLFV.YSSSSITK.LM.mEKVNVTKSTF.EsA..K..KT......FK..TKSKRTA....LVEKDIKIVTRKMQ....N....LT.LMLLPLFFTLPTV.....FSIYATGSIGTln....assAYLGLLS.LLIIS..ASFYSM.QLIIS..EGDGL......ENLRIL...PVTNWDIIKSKLTTGLIIFSLFSIPI...IFILVGIGI...LR.ITLDI.LIEIDLA.VGYI.FASIISLRWLmkk......ipkDAMTVNFYSFnGSLGIIFLFAVTA.ISAGIFP.IMVILIYTFLAssifans.feflmliFIFNI---.-....---------
T0NBP7.1/46-518      -IFITYAVTAISMIAF.SSFLTYTQIRLPDPV.........dHLQ....TLS....LL..LY..AYIFIISL.YSFIMFTNIVrtyRLFE..PLKPLPTRIGH..Q.VL..PLS...WFVFTGSSSLFVI...vPILWAY...IyIT..GNILS..AFTGV..L.WAFIMLGLG.YT...AGSA..MIYILSGSVE...RkrglRS..GS..IST..I..LRVTGFIA----FFILFEIAIQIPQEIpvlps.irghlSYLFVPLLNSAYIIFP........AAQPSSYV-YYG....MAAS.FI....YA..LMALFLFL.TVNMRTFS.RVtqTETVSYNTAD.I.S..Q..KK......LHesKSGFYIT....IFRKDVRNIFRKSQ....N....FL.MMLIPVFLVLPTL.....LSIFFYSSDVTfg....sisIYYSMLA.IVIVS..SAFYSI.VLIIS..EGNGI......SVLQAL...PVRLMDIIYSKEYVGAAVFAAIVAPI...SVLFLMKAR...GN.PVIFF.LFPVNLV.IAYI.YSSLYNLRRLmrk......vprGATTVNFYSFgGNTELVILFAITA.LLISLPT.LVSTVISYISLgitfs.....hsvafYL------.-....---------
A0A133VIS3.1/47-494  --VYTNLSLLPAFLTF.SVFLAVPMINSSGSPl........gLFL....ILL....MI..QL..FFSAIITL.TSMSNFRSL-...RLQN..PLLSLPIDREI..F.AV..SIS...WIFSGAFPILVVTi..pAAAAYG...W.SI..GSFIP..VIFAL..V.WGFLSVFFG.HS...IGLL..LSNIFSFRVSs.nS....KL..GK..LSQ..I..LKMGGVFL---FLFLWYFV-IYSDRNLg........nfFKPLSPLVESLDFIYP........FTASESIVNFSYi..dIFSF.FL....YG..MIFIGLYL.IVGKKTWN.NL..REPSFRISDK.I.E..N..IT......IS..LKGKLLG....CIRKDIDLSFRNNH....I....FS.VLIFPLMVLLPNL.....IRVIQGNQLDP.........VTAEVVFlLAGIL..SAMGVV.NFYVG..EGKAA......WIISTL...PISKKEFAFQKALAVFLVFPFFAVPI...ILVISFLIG...LG.IEYLS.LYIASAL.AVAF.TSSIVFSNSLndk......lpeNPVVITQESFgTRLAPILTLLKSA.IISIWPV.PLSLLLYYVLNgf...........spS-------.-....---------
A0A133VFV9.1/53-509  --------MIPFFAML.SFFLAGAQVATGMQI.........gAFS....LLL....LV..QL..FISIFITL.NSVSTFQDL-...GMHK..PLLPLPISREY..L.VV..SLS...WLLSGGAAILIIPl..lAAIIYA...W.TT..GTYLA..IPMSF..L.WGVLTMLLG.HS...LGLA..VTNLFSFEAS...E....RS..TL..GTAfrF..LKIGGALL----LFLLWFFIFTQEGFLs........plLEPLTAISKSLWFLYP........FNASRSIVSFSSv..yMLSL.LL....YG..SLFSGIYW.LAGSRTWE.NI..TAPSFAVSET.V.G..E..LR......ME..IGGKFKS....LIKKDLTLSFRSGQ....K....FLgILAFPLMILFMNL.....IDVIRGGTVSLf.......qAEIIYLM.T-AIL..SGFGII.YLYIQ..EGESA......WIMSTL...PISKKDFALQKALSAFSLFPLYAAPA...ILLVSVKMR...YG.IPVVL.MQFVSGF.AMAL.TSCLVVSNSLadrlp.enltviTQETFGSRYT.PLLLVLKSGILSG.WPVLASI.GLYLVVTRPLSala.........gsiILLTLTTT.L....V--------
A0A133UZ77.1/2-387   ----------------.---------------..........---....---....--..--..--------.----------...----..-----------..-.--..--S...WLLSGGAAILIIPi..pAAIIYT...W.AT..GNYLS..ILVSF..L.WGVLTTMFG.HS...LGLI..VTNFFSLKTT...D....RS..TF..GKA..LriLKIGGALLL---FLLWFFI-FTQEGFLn........plLKPLTRISETLWFLYP........FNASRSIVDFST...vYLLSlFL....YG..FLFSAIYW.LAGRRTWK.NI.tTPTFAVSEKV.-.E..E..LE......IG..ISGKFRS....LIKKDLTISFRSGQ....K...fLS.ILIFPLMILFMNL.....IDVIQGGTISL........fRAELIYI.AIGIL..SGFGII.YLYIQ..EGESA......SVMSAL...PITRREFSTQKALSAFILFPLYAIPA...ILLVSVKMR...YG.IPAVL.MQLVSGF.AMAL.TSCLVVSNSLadrlp.dnptviTQETFGSRYT.PLLLLLKSAILSG.WPVPASI.GLYLIITRSLS...............ALVGSIIL.L....ALTTILV--
T0LED0.1/47-504      -VRSSLYVNTIIYAII.SISFGAISTESNASN..........NSF....ILF....LL..LL..ILAIMSDT.Q-FYRGVWDM...KLLT..PLSQLPLKVEK..R.VV..PFS...LFLYNELYLPFVT....--IPAG...I.VI..SLEMR..SPLPL.vV.FSLFTVLFI.YVarlVSLL..LGVTFVKTNT...N....RR..TK..RLY..L..GQVFQVVIFVIFILAI-EI---AANPS...........FQGFVKIPQFLYYFVP........VASQYISSLSVY...pFASF.AL....VF..AVVYPSYL.YVQKRSFTeRM..ETFADVTEGA.K.K..N..VA......LR..IRKPVRS....LMDKDFKVILRRRG....A....IM.IMVVPVTFIIPII.....PTLLTVSSGTL.........ESVFYIP.YISLV..FLIDFV.LMIGL..EGKAA......WHLSAL...PITRRQFFFSKLLSIFTIGLVYYGAI...TAIVGIVNKgmvSYmLFNYP.FFAIILT.AVLF.AGGTYLVNAIpnevytlsqegiGGRWVFMK--.TFIIGLPIIVLNA.LAFAFAKyIIGFSASYYIR..............gYTLTIAIDaL....VSY------
E0STR5.1/65-451      ----------------.-------RLIETGFDp.......snAFK....LFL....TL..IT..GFAVLLVL.LSSATFTSTImreNIID..ILKTLPLRDIDilK.IY..LVA...LILYWGGLSAIFI....YIPFIV...G.EL..IAIYS..GILSV..E.IMLLTILIAiLV...LGTS..YCLGIGLGAY...S....HR..GR..YRV..S..IRALSTSLWIVTAIAFSSIYYLFYNMLi.........tIRAIESIAYSWGYLLPiv....giLYSNTVERTIVS....LIIT.VT....IV..LISIGIAI.QNMNRLIY.SE..PIKAIHRKPA.I.E..R..FE......LG..IKPILIA....AIVKDLKLIGREPRllsaA....LI.TILIPLVMVIPSA.....ISRVFEIG--Eipfe.gsiiLSSILSI.AIGFM..GSMGID.HFYFS..EGRGS......VLLYYL...PISRRMVMLSKALASSAIASPLTAL-...-ITGIITFL..iTD.SILSA.TAFGLTA.MIIT.IAFSII----............----------.-------------.-------.-----------...............--------.-....---------
H2J528.1/85-464      ----------------.---------------..........---....-FL....TM..GF..MFFLNYSP.AIVANLFES-...EITQ..LLLVMPVKRFE..I.YTasAID...SLIMAGIPLGMMI....PVFVVY...A.ML..MKTNI..-ILTI..L.AG-----LG.YI...LFLM..LLSNFGGVIL...S....R-..FL..TKT..S..AKRWTMIMYFVSIFLYVGGTNLLPSLVad.......nsLEELVAAFNKTI---Glil..ndfWPHTWVLKAMNGs..iTFLA.IL....YV..VISILGYFiYGISNTME.F-..N-TSSGKKEK.H.S..Q..KE......IS..IKHSKFP....MFKKDFKLLFRDSQ....T....FF.LILYPIFLPIIFI.....FTSESLEMIGT.........---MYVL.LSSMY..AAMIAL.YSVTY..EGKIW......PIPKLY...PLKPWELIFSKVLIPVFIFTLEYVIL...VIAIILMKK...SS.SIIFY.SIIPIFL.IILY.SAILGVSMYL............KNPKRDLSQK.NVLNGKEVFILEG.ISL----.-----------...............--------.-....---------
A0A1G6L8J9.1/61-489  ----------------.--------------EimpgvtfaelMAS....MYI....ALmsLL..FFLQYSPA.IINTL-FNN-...DNIE..FLLTTPVKKGT..I.FL..--S...SAIDSFLVSGLPIgmmlSVIISY...G.IA..ADVNIfnLIISS..IgYIFLMISLS.LI...AGLI..FSYFIGKTAA...K....RF..SQ..LMY..F..ASIFAFVFMTNFIPTD-QINQAQQGQL...........SGIFGNMTFLTGEFFPhtl..llkSMHGNIYF---G....LLSI.LI....SV..LIIVLIYG.VST-KLDF.V-..--TSRKKSKN.K.-..E..QK......IK..LTGGM-P....VLKKDLRLLQRDSQ....S....LF.LILYPFLFPLIFI.....FINVQS-----.........MAAMNIM.FIFIG..SMYAAI.LSVGM..MVNDMk...iwPIPKTY...PIKTEQIINNKISIPLIIFLTEYVII...TIISAVLGY...TN.IIDYF.MVIPVGL.LLYY.AALYGVKTYLknpq...rdtsnKNNVLTFKET.IVFEGIIMGF-GA.AIFGLLT.VYKINMQTPIL...............DWSTILIN.L....VF-------
A7HJN6.1/86-511      ----------------.---------------..........---....--M....NI..TMfsIFYIVGFI.GTGMYAFSRT...DELE..LLLTMPIK--R..R.IL..TIY...NLIISLSSQLFTI....AFFLGAtfgF.ML..GWKNV..SYTFL..L.KTLLQLCFI.TS...ISAL..FSILSGGIN-...-....--..--..SKS..I..VRKINVIIVLLLVF-IYFGFSYLQDID...........VTKLAENENIIRWFAFtt....skYNVLTWAYSSDK....LLIS.II....IAisIVASILFW.YLADKVIY.E-..--EIRTKTKK.K.D..E..VK......LS..NNSSYASkfgpFFWKDLKALQRNEQ....F....IF.LIFYPVAFGLF--.....MMFVSNSV-IS.........SSVPFLA.IAVLY..CAMESG.LLTMD..EFKYS......EIVKIL...PSKKSSIIIPKLVIPVSMNFLLLILInlvALLTNRYSK...EA.FIFLP.LALLLFL.LSAL.IGAYYSITK-............PGRRKNQP--.--FTTVTTFIIEG.ITLGLAF.GMLFPIGYLSAgpkskgwtiilswtsLIVSIVLS.I....ILAIVYYKK
A0A2U0RWM2.1/50-484  -----------GFVVA.AVLV---ALFAGNILealg..agmfMFQ....IAI....FL..PA..LMTLASVM.YGLLFEFSQSssvGSSD..VINWLPIHPAE..F.VL.aSVF...SMLYFLAPIIGIVf..gATLGLA...L.TA..SMLDV..GLFTM..I.VSCIGLFLGaFS...LEIIraITNRVSSSVY...K....RT..GR..SAI..I..IRMVVFVL-MFVVYMLLSNVNFLFSILd.........qYMNGIQSAWFIPILWPslt..imsYMTTEVLQVIVY....LLLS.VV....FT..AALLWAGV.KLREKYWV.PA..PFALKVTSTK.D.Y..A..PKqgilgrFG..FTSAEAA....LLKKDFRGLTRRKE....M....LV.WIAVPIGISVISF.....FSTPSSLADSAtt....fdrLSLFWGP.LMGLF..MFAFYI.TITSIgqEGSAF......LNLRMI...PLNGKEVIRAKLSTALIPSSLAMVVV...TVLIQIMLQ...LR.PEALV.ALAVTLFaAVFE.CAFVGVALGC...........rYPDFTEVPRA.RFIDQKGVWL---.-------.-----------...............--------.-....---------
A0A2U0RVN2.1/24-419  ------------FSVLaAVIPFTAQFFGSPVL..........GLT....SAV....SL..SL..VVTFGFTAlYAIQTFSSFVs.pESSA..LLSTLPLEQRD..FsLI..TLF...SFVRSVDYIVVGS....-ILSQV...I.LV..AYVTA..SLFAV..L.VMLVASVMN.AV...LAVA..AALWFSRMFTnnlS....RG..GRskANS..V..LRLFFILMWGSLLMGVSFLISLPWYIVp........slETLLLSSNQLSSVLFCllhpfsvgITIASIGNPVTAg.srALIA.AVcmvgYV..VFSGFAAS.WIIKT-VK.RI..SDGTDVKMSR.V.T..AkdFS......VK..TRAPLFG....YVLKDLKTASRNPA....T....AF.FFALPVLETVIVS.....FLIANFEVLRAs.......tLLVS-TF.MGGIF..VLIMPL.ALLNA..EGAGL......EYTKTL...PLNINRIILSKTLISTLTYVPVPI--...VLLVMALL-...-K.PVTSP.LAILIPF.FVISaIA--------............----------.-------------.-------.-----------...............--------.-....---------
A0A4Z0D8G0.1/139-423 ----------------.---------------..........---....---....--..--..--------.----------...----..-----------..-.--..---...-------------....------...-.VI..GIVYA..ILIEAniI.LSVMAILLF.IL...LLLF..LSLLLGSVF-...A....R-..IM..TKS..S..AKTISQVFLYVSIIGYVVIMNLMPRQInaspeetlnsfNSFFGIIRGEYSYLLPi.....nwFMYLTSLDLKTI....GLVS.LS....IV..IMGYFIYK.NSNHFALE.S-..---GRGKAKV.A.K..G..VN......VS..R----HP....VINKELRLTFRNPQ....N....LF.GIAYAIVFPVI--.....MLLINKQFISG.........AMFVALF.ASMYT..SNLSMQ.L-MSV..ERKTW......PLTRLL...PVDDGFVLKVKAMIPAAIYTLVYLIV...LIVAYFGIG...LN.PIMFL.SIIPMIS.VLLF.SS--------............----------.-------------.-------.-----------...............--------.-....---------
A0A328VJ84.1/324-475 ----------------.---------------..........---....---....--..--..--------.----------...----..-----------..-.--..---...-------------....------...-.--..-----..-----..-.---------.--...----..----------...-....--..--..---..-..---------------------------...........----------------........------------....----.--....--..--------.--------.--..------QGQV.R.T..S..WF......AR.fLSSQTLA....IAAKDLRYFRRDPQ....L....LG.QLIMPLVVACVAL.....VAPFLGRNAGRvae...dswFFLFYPP.FIVFLylSMLSIN.-ALGL..ERKPL......TVLLLY...PIKPERLFFGKNLAVLVPGL----VL...LLAMLAFE-...-S.LFLGL.WHLVLPF.LVAG.LASI------............----------.-------------.-------.-----------...............--------.-....---------
A0A4R3KYA1.1/150-424 ----------------.---------------..........---....---....--..--..--------.----------...----..-----------..-.--..---...-------------....------...-.--..-----..--LNI..L.LSIIGLLLF.MV...FIFL..FSFTIGSIM-...A....R-..FM..KKS..T..ANIFSQIFLYVSIIAYVVVMNVFPRQAenfea.ildsfHGIFGILEGKYAWIMPt......nWFLYAVKGDNRV....FILL.GL....LS..IIFAFVII.KATN--VF.NM..-DSGRSKSKT.K.K..G..IQ......IS..RYP----....IIKKEIRLIFRNPK....N....IF.SISYAIIFPLV--.....FTYIN-KSILS.........GAMFVAL.FSALY..TAILSI.QLITE..EKKSW......PFLKLL...PIDMDKVIRYKAFIPAIIYTLDYVIV...LLVGYLLID...VE.PIIFL.SIIPMIA.VILY.SSAF------............----------.-------------.-------.-----------...............--------.-....---------
D1CHW3.1/281-437     ----------------.---------------..........---....---....--..--..--------.----------...----..-----------..-.--..---...-------------....------...-.--..-----..-----..-.---------.--...----..----------...-....--..--..---..-..---------------------------...........----------------........------------....----.--....--..--------.--------.--..---TSTRSHR.S.G..R..DR......AG..ARPPWWS....LASKDWKELRRDPQ....H....LV.GLLYPLVIFGAGV.....YRSLAVASTRGe.......gWPIFATI.DMGMY..FMIMTL.AQPSInrEGRRL......YLLTLC...PLSPREIFVGKWLYAAVPPLALAAAL...DIAYGLWAG...LH.PLATIyMLLITTL.LAVT.LAG-------............----------.-------------.-------.-----------...............--------.-....---------
A0A329MEN8.1/8-140   ----------------.---------------..........---....---....--..--..--------.----------...----..-----------..-.--..---...-------------....------...-.--..-----..-----..-.---------.--...----..----------...-....--..--..---..-..---------------------------...........----------------........------------....----.--....--..--------.--------.--..----------.-.-..-..--......--..----FRA....MVKKEWKDAIRNPQ....I....LL.NAGMPILLAVL-F.....RQKGDDPDNLA........fFSIPILI.AISIT..GAFVQA.NM-IA..EEKEK......HTLRSLmlsPASKLEILAGKSATTTLFALIVIAAC...LAISGVPDV...NF.AY--L.TILAVML.LLIF.MA--------............----------.-------------.-------.-----------...............--------.-....---------
B7IHL1.1/67-484      ----------------.--------------Sr.......lmFLF....WVS....IL..SL..FFIVGFIG.LA-MYSLSRN...DELE..ILLTMPISRTTltV.FQ..IFT...ATISQIYVLVFFV....FVTLAY...L.IAakGNILI..GIVQL..I.VHLAFLLL-.--...LSST..IAILIGGKT-...-....--..--..SKS..F..TRRFYMIIVLLSIFFYFFIIALVD---...........-VDVAELQNLVKMFLFstk.eyniLAWSFIST--KT....LIFS.II....SA..AILFILFR.IISSKIGF.E-..P--IQRNSKK.R.-..Y..DK......KG..SGSVLNA....IIKKDLKATIRYEQ....F....LY.FVLYPIGFGIF--.....-MMFLNKDILS.........PLMFTIP.IFTFY..IALETG.ILMIS..EISKI......EYVSVF...PVKFSTLVFSKIAIPVLINIILLLII...FIVSSIFYS...LN.LLVLL.GLLFALL.LFTM.SSILGAYFAIs.........ssNLKIVNMNRIfSISQTLILEAVTMgLAFGSII.PLGILIQQQSLeww.........gwlIMISSLAT.I....VLISIL---
A0A448V0I3.1/77-448  ----------------.---------------..........--L....SVV....DL..VL..LLLFVLMA.LGTFFQFRDLf.fHSFDenTLWALPIPKES..F.IL..AKFsgsWMTEVPMILAFSV...gSLVLCY...L.AT..ESLFK..VFLLL..L.SFLLTTILG.EA...VGGF..LRIAFSRISS...G....REmpKF..VKS..L..I--AVAIFATFMILYYYEIAQEFRHIAe.........fSAFYNNLPGPFHLFSYm......lSAHIWVFIPYAL....LAIG.IF....YL..------FL.TYMGKHFF.EI..AERLEKKGAT.K.VigE..DA......FS..PRSKRSA....LLRKEISLYWSNTA....VamntFF.GILVPIILSLLLF.....VPSLREAFLYFiesqsllprDAFIFLA.AMGFG..GMMNIStFFFSL..EGKNA......YNTYAL...PLSGREIFLTKLAAGLVLSL-PSLLL...SIVLVIIAL..qPA.AAYWP.FLLLAPL.AYAC.LSN-------............----------.-------------.-------.-----------...............--------.-....---------
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