# STOCKHOLM 1.0 #=GF ID RskA #=GF AC PF10099.10 #=GF DE Anti-sigma-K factor rskA #=GF PI DUF2337; #=GF AU COGs; #=GF AU Finn RD;0000-0001-8626-2148 #=GF AU Sammut SJ;0000-0003-4472-904X #=GF SE COGs (COG5343) #=GF GA 35.20 35.20; #=GF TC 35.30 35.30; #=GF NC 35.10 35.00; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cut_ga HMM metaseq #=GF TP Family #=GF RN [1] #=GF RM 17064366 #=GF RT Mutations in Mycobacterium tuberculosis Rv0444c, the gene #=GF RT encoding anti-SigK, explain high level expression of MPB70 and #=GF RT MPB83 in Mycobacterium bovis. #=GF RA Said-Salim B, Mostowy S, Kristof AS, Behr MA; #=GF RL Mol Microbiol. 2006;62:1251-1263. #=GF DR INTERPRO; IPR018764; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This domain, formerly known as DUF2337, is the anti-sigma-K #=GF CC factor, RskA. In Mycobacterium tuberculosis the protein #=GF CC positively regulates expression of the antigenic proteins MPB70 #=GF CC and MPB83 [1]. #=GF SQ 70 #=GS 2001289524/28-217 DE [subseq from] '[Soil: Diversa Silage]' #=GS ECU93447.1/77-254 DE [subseq from] hypothetical protein GOS_2994968 [marine metagenome] #=GS ECW00723.1/86-254 DE [subseq from] hypothetical protein GOS_2796929 [marine metagenome] #=GS EDA86833.1/81-272 DE [subseq from] hypothetical protein GOS_1922523 [marine metagenome] #=GS 2001334258/62-217 DE [subseq from] 'Uncharacterized protein conserved in bacteria [Soil: Diversa Silage]' #=GS ECW26558.1/86-254 DE [subseq from] hypothetical protein GOS_2751657 [marine metagenome] #=GS 2001302566/53-249 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBF31157.1/13-188 DE [subseq from] hypothetical protein GOS_9618520 [marine metagenome] #=GS 2001219367/60-235 DE [subseq from] 'Predicted transmembrane transcriptional regulator (anti-sigma factor) [Soil: Diversa Silage]' #=GS EDJ40544.1/65-263 DE [subseq from] hypothetical protein GOS_1701239 [marine metagenome] #=GS 2001221937/40-239 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBO93364.1/75-239 DE [subseq from] hypothetical protein GOS_7995556 [marine metagenome] #=GS 2001256895/65-226 DE [subseq from] 'Uncharacterized protein conserved in bacteria [Soil: Diversa Silage]' #=GS EDJ19572.1/66-227 DE [subseq from] hypothetical protein GOS_1738399 [marine metagenome] #=GS EBW53489.1/36-193 DE [subseq from] hypothetical protein GOS_6731585 [marine metagenome] #=GS 2000506810/58-302 DE [subseq from] '[Sludge/Australian, Phrap Assembly]' #=GS 2001448442/68-233 DE [subseq from] 'Uncharacterized protein conserved in bacteria [Whalefall Sample #2]' #=GS 2001258707/65-241 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBF71206.1/55-208 DE [subseq from] hypothetical protein GOS_9553027 [marine metagenome] #=GS 2001490513/62-210 DE [subseq from] 'Uncharacterized protein conserved in bacteria [Whalefall Sample #3]' #=GS EDA12377.1/77-252 DE [subseq from] hypothetical protein GOS_2059546 [marine metagenome] #=GS 2001238234/80-188 DE [subseq from] '[Soil: Diversa Silage]' #=GS EDA77723.1/62-218 DE [subseq from] hypothetical protein GOS_1939221 [marine metagenome] #=GS 2001294195/14-108 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBZ67954.1/5-119 DE [subseq from] hypothetical protein GOS_4362528 [marine metagenome] #=GS 2001487789/6-164 DE [subseq from] '[Whalefall Sample #3]' #=GS 2001345598/4-118 DE [subseq from] 'Uncharacterized protein conserved in bacteria [Soil: Diversa Silage]' #=GS 2001494198/21-122 DE [subseq from] '[Whalefall Sample #3]' #=GS ECN56201.1/61-217 DE [subseq from] hypothetical protein GOS_5420827 [marine metagenome] #=GS EBF11173.1/80-240 DE [subseq from] hypothetical protein GOS_9650954 [marine metagenome] #=GS ECX57881.1/45-235 DE [subseq from] hypothetical protein GOS_2512998 [marine metagenome] #=GS 2001304927/13-109 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBF11836.1/45-201 DE [subseq from] hypothetical protein GOS_9649808 [marine metagenome] #=GS EBV25338.1/77-243 DE [subseq from] hypothetical protein GOS_6934298 [marine metagenome] #=GS 2001473491/8-136 DE [subseq from] '[Whalefall Sample #2]' #=GS 2001445009/62-176 DE [subseq from] '[Whalefall Sample #2]' #=GS ECD17777.1/3-73 DE [subseq from] hypothetical protein GOS_4460796 [marine metagenome] #=GS ECT06564.1/3-131 DE [subseq from] hypothetical protein GOS_7097943 [marine metagenome] #=GS 2001431388/1-102 DE [subseq from] 'Uncharacterized protein conserved in bacteria [Whalefall Sample #1]' #=GS EDJ23603.1/8-126 DE [subseq from] hypothetical protein GOS_1731388 [marine metagenome] #=GS ECW17711.1/78-225 DE [subseq from] hypothetical protein GOS_2767047 [marine metagenome] #=GS ECK62886.1/73-248 DE [subseq from] hypothetical protein GOS_3129133 [marine metagenome] #=GS EBD82099.1/70-270 DE [subseq from] hypothetical protein GOS_9866821 [marine metagenome] #=GS EBC77628.1/16-155 DE [subseq from] hypothetical protein GOS_15976 [marine metagenome] #=GS EDH17579.1/66-248 DE [subseq from] hypothetical protein GOS_652696 [marine metagenome] #=GS 2001470601/6-76 DE [subseq from] '[Whalefall Sample #2]' #=GS EDI21112.1/89-249 DE [subseq from] hypothetical protein GOS_469983 [marine metagenome] #=GS 2000461410/66-228 DE [subseq from] '[Sludge/Australian, Phrap Assembly]' #=GS EDJ57470.1/158-324 DE [subseq from] hypothetical protein GOS_1671526 [marine metagenome] #=GS EBF92636.1/47-246 DE [subseq from] hypothetical protein GOS_9517980 [marine metagenome] #=GS 2001078020/8-149 DE [subseq from] '[Sludge/US, Jazz Assembly]' #=GS 2000222610/6-147 DE [subseq from] '[Sludge/US, Phrap Assembly]' #=GS EBB60714.1/45-202 DE [subseq from] hypothetical protein GOS_205009 [marine metagenome] #=GS 2001236632/104-268 DE [subseq from] '15 Serine/threonine protein kinase [Soil: Diversa Silage]' #=GS 2001371310/59-253 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBB35623.1/9-91 DE [subseq from] hypothetical protein GOS_247153 [marine metagenome] #=GS 2001267199/30-115 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBS03824.1/87-170 DE [subseq from] hypothetical protein GOS_7500959 [marine metagenome] #=GS EBT03550.1/145-228 DE [subseq from] hypothetical protein GOS_7339757 [marine metagenome] #=GS EBS05116.1/150-233 DE [subseq from] hypothetical protein GOS_7498849 [marine metagenome] #=GS EDJ44180.1/115-298 DE [subseq from] hypothetical protein GOS_1694735 [marine metagenome] #=GS EBR97649.1/176-259 DE [subseq from] hypothetical protein GOS_7510886 [marine metagenome] #=GS ECZ08781.1/177-260 DE [subseq from] hypothetical protein GOS_2244017 [marine metagenome] #=GS ECU87114.1/175-258 DE [subseq from] hypothetical protein GOS_3005030 [marine metagenome] #=GS 2001218610/36-121 DE [subseq from] '[Soil: Diversa Silage]' #=GS ECZ06058.1/41-123 DE [subseq from] hypothetical protein GOS_2248690 [marine metagenome] #=GS EDA11315.1/162-245 DE [subseq from] hypothetical protein GOS_2061465 [marine metagenome] #=GS ECO30414.1/147-230 DE [subseq from] hypothetical protein GOS_6006160 [marine metagenome] #=GS EBT54878.1/144-226 DE [subseq from] hypothetical protein GOS_7255518 [marine metagenome] #=GS EBS81057.1/155-237 DE [subseq from] hypothetical protein GOS_7376944 [marine metagenome] 2001289524/28-217 PSSALRERVLGAIAQIPQDPRVEQVSEK.GAPRRSWTPF----....................................................VPLAAAAVLL.LVVGim...............................................afrIDQSRRELLERVARYATQ....TDLALSILTAGdmrei............plagreGAASAAARAYV.....SPTR.GLLVV-ADRLP.APPP.GRAYQVWVI...-EGTK....P..LSAGMLg.eePGGRGMLI...VTP...P.K.A.G.MG.S..SVT..VAV..TDEP.PGGR...-PE...PSGTIRL-- ECU93447.1/77-254 PPARTWTRIQHQLGFIPPSRPRSAAPSD.GWWNNLKLWR----....................................................WVGMGASVAA.LGLL....................................................TVNVIRVGEAPPRPAAED....SRYMAATLAQA.......................DGVARWTATVD.....LRRA.RMVVVPANT-P.PVAA.DRSTELWLI...PPNAK....P..ISLGVFa..sNAPASMTL...PQA...I.V.A.R.LD.A..RAV..LAV..SLEP.HGGS...-PSg.qPTGPVLATG ECW00723.1/86-254 PPDALWQRITDEIESDGAVGGSAADRAN.SGGRAWMGR----F....................................................ALAAAVGVLV.GSLGtivam..........................................dretpPPTIAQAELEPLPGKDAR....GVAQVRQTAQG.......................-----------.....----.AKLVVDVPGLP.--AT.DGYYEVWML..aPDAES....M..VSIGVL....GNGEVNEF...PLP...D.G.M.D.MN.R..FPV..VDI..SVEQ.FDGD...-VT...HSADSVVRG EDA86833.1/81-272 PPATVWQAIERRLDLNLAREAARPRTVA.EKPARPSR-----Sifenlafw...................................rgwaigvtgFAVIAAVVAV.RSLL....................................................PGAAPTPTTPTVAQQPEA....AVSHVAVLNDK.......................NTHPVMLVAWD.....ETHD.TMTLHPLGKV-.DLPA.GRVMELWGI...PASGH....A..VSLGVL....-PDSANGK...VTA...G.R.Q.K.PE.S..YAA..LAV..SIEA.PGGS...-PDhnaPSGPVVFSG 2001334258/62-217 PPADVWPRIAAAVGARTERPQHGVGL--.-------------W...................................................qALAASLAFLA.VILG....................................................---------ALYFGQRAD....QAQYVAVVADQ.......................--QTGPIWLMQ.....AFTS.ELRVTTVDDR-.PEPV.GNSYELWML...PEGAA....P..VSLGLIp..gAGNAVLPL...SAA...Q.L.G.V.LA.Q..TAT..LAV..SLEP.AGGS...-PTg.aPTGPVLFT- ECW26558.1/86-254 PPDALWQRITDEIESDGAVGGSAADRAN.SGGRGWMG-----R...................................................fALAAAVGVLV.GSLGtivam..........................................dretpPPTIAQAELEPLPGKDAR....GVAQVRQTAQG.......................-----------.....----.AKLVVDVPELP.--AT.DGYYEVWML..aPDAES....M..VSIGVL....GNGEVNEF...PLP...D.G.M.D.MT.R..FPV..VDI..SVEQ.FDGD...-VT...HSADSVVRG 2001302566/53-249 --------LLTALPAKPPSAALRKRLQS.QLPSAQKTVQKTMQkesrlhf......................................twsfgqlAMGTALALLV.-LFNlf...............................................sflQMREIQRQQATLQQQLKT....NQFALSMLAYPstq................afpiSGDNLSGSVLL.....DRER.NTVALVMWHLP.ELSA.DQTYQAWLI...EPDGQ....R..VSAGVFr.pqNTTAYTTQ...PIY...A.K.Q.D.IS.N..FTG..VGV..TIEP.SGGS..eQPT...--GPRLF-- EBF31157.1/13-188 PSDYLWPRIERSLNASATRLPQTVSRRA.PHAHMPRSRWWHSLpvw..............................................rgiAGAGLAAALA.MGVL....................................................--------LTNVTTTPAT....PEYMVVLLAPQ.......................-TQSAGWVVQA.....ANRQ.EIQLIPLGTF-.EVPE.GKALEFWTK..aDDWQA....P..VSLGLV....EPGQPLRL...RLD...Q.L.P.P.LE.D..NQL..FEL..TLED.DSGS...-PTg.lPTGPIEF-- 2001219367/60-235 PSSELKDQLMQRVHTTRPKEQARISPQTaRPWLERLLPAWGLAs..................................................lFLIIALAASS.LVLW....................................................------QRVNRLEFATSP....GGMQAVPLSPP......................dAASSATGFVLI.....SADG.DDGAVVVDGLP.PLGE.NQQYQLWLI...-RDGQ....R..TSGAVFs..tDEKNYGGT...RIR...A.P.R.P.LT.D..YSA..VGI..TIEP.TGGS...-PN...PTGAQVL-- EDJ40544.1/65-263 PAPRVWEEISTEISADATSQRPQDARMP.VSAGQQSPIAEAPTtdqspagndds.............................gvvvplrrrsapWLAAA-AAVG.VLFGaiggvvw......................................tqgsntePTVVAQASLEPLPGFPSR....GVARVQSTDVG.......................-----------.....----.DSVTVDLQGLP.--AT.DGYYEVWLL..tEDASA....M..VSLGAV....GPGETSTL...PLP...P.G.I.A.LD.R..FRI..VDI..SAEE.FDGD...-PT...HSTISVARG 2001221937/40-239 ------------------------RKVS.GESKRVTPP----Dtpgiynga....................................tpvargvnWYAIAATLAL.VITGaqlfrvtsern..............................rmrreaaavaeDTVVSRPANDSTPRLLAQ....RDSMIAAMTGPdvkvv.............plmnqSAQQPVGRMMW.....NRAS.NDWVMVTYNLR.PPKP.GMTYQVWIV...-TDDA....K..ISAGTFk..pDASGRTMM...RAR...Y.A.L.D.RN.A..LRS..VAV..TEEP.EGGM...-PA...PTGPMVIAG EBO93364.1/75-239 PPDGLWGRITAEIESDGPVVPQGRAPRG.ARM-----------....................................................GWFALAAAVG.LLVGsvgtfv.......................................atdqrnpAPAIAQAELEPLPGQQAR....-----------.......................----GVAQVRE.....TPNG.PVLMVDVADLP.--AT.DGYFEVWML..tPEADS....M..VSVGVL....GDGSVSEF...PLP...S.G.M.D.MD.V..FPV..VDI..SVEQ.FDGD...-VT...HSADSVVRG 2001256895/65-226 PSAQVWDRITAALPGAAAPRAS-LWDSL.AFWRGLTFATG---....................................................ALAAACVAAL.VYIG....................................................--------------NFTQ....PTPLVASLAGG.......................-GQNAFVAAVD.....PRRG.TVMIVPASFA-.-QAP.ERVPELWLI...APGDK....P..RSLGLI....DPSKPVTL...TIP...A.S.L.L.AQ.AnaQAT..LAV..SLEP.PGGS...-RTg.aPTGPVIATG EDJ19572.1/66-227 PPAQLWDQIEQRLFPEPQASNVAAGQGL.WFWR------WS--....................................................AGLAMAALLV.VLIW....................................................-----------TPLPSQS....TQGVVAVVQSE.......................-QAQPLWVMNA.....SAAD.HSLTMKALPSV.ATNT.GQDFELWLL...SGSGV....P..VSLTVLp.teGAELRIQL...SNE...Q.A.R.E.LL.K..SRS..LAI..SLEP.KGGS...-PTg.qPTGPVLY-- EBW53489.1/36-193 PDEAVWEKIASRIDPNVVPLQLKTKKPR.STILQAWSL-----....................................................IATAASIVLA.LIIW....................................................----------QPHESVTS....QAQQIALFKNQ.......................--AESALWFID.....VQDD.SLAIKASTAL-.IPRT.DKDYELWMI..lKGQEA....P..ISLGLL....PKSGRIEL...PKN...A.Q.F.N.AN.D..IAL..LAV..SLEP.LGGS...-PNg.sPT-E----- 2000506810/58-302 PPASMKRRIRDKIRARGGRRFAPSAGAV.IGT----------L....................................................GWALAAALAV.AAVWlwndrsrltqdlaaaskilasvippanaeekdkppalsleeelkklqagfdqKQAALKAELQTARQKETE....AQSKITGLTSEvdslkkeasefkmeftadqstvwEYRRSTMMIVW.....DGKS.RQGMVVLDKMP.KVEA.GKDYQLWVV..dPAKPA....P..VSAGVLt..vDAKGAVKT...NFK...P.V.E.E.VG.S..GLK..FLL..SVEN.KGGA...-PQ...KTGPVIF-- 2001448442/68-233 -------QLGDQLRIKDQLSSVQTATSV.PPEPANLNVAPKKWv.................................................tgLLAASIAG--.LVLG....................................................--------LGFGWMQPMP....EPKVVAVLLDA.......................--NGVPQAVVD.....DYGD.DTATVRFVADI.SVPA.DRTLQVWTL..pSADMG....P..RSLGVL....TGAAATQL...TFE...D.L.P.D.PG.A..MQL..YEV..TLEP.LGGS...-PTg.rPTGPIIGKG 2001258707/65-241 ----------------------ALRKR-.-------------Lqgrlpgaqtg...............................rrarlnwsfgrLAVGTAILLL.LALNlf...............................................sflQVRALQSQQAKLVDQIQN....GQMALAMLSYPntq................afpiKEQNVMGSLLL.....DKEY.NNAVLILRGLP.AIAD.NQTYQVWLI...APDQE....R..TSAGLL....RPQANLPFisqPIN...A.T.Q.D.LT.N..FVG..IDV..TIEP.VGGS..nHPT...--GAQIF-- EBF71206.1/55-208 ----------------------------.-------------Gieaqlfpetr...............................qplwqrlglygLGGVVAALVL.YVVT....................................................-----NAGWLQLGPEPQL....APELTATLASE.......................DGALRVTAAYD.....AETG.QLFVDRALG--.APAT.GRDLELWLI...AGEAA....P..VSLGVL....PAARTARV...TLP...Q.T.L.R.TG.L.pGAV..LAV..SDEP.AGGS...-PTg.aPTGDVLAL- 2001490513/62-210 PSDDLWPKILQQIENQPQPTKTIIRTQP.SIW--------RTW...................................................sFVATAASIVL.AFLV....................................................----------MQPATNVS....NIQQIALVQNK.......................--AQQPLWFID.....VNEQ.ALSIKASGQL-.VAKT.DKDYELWMI..lKDQDA....P..ISLGLL....PKTGSKTL...AKN...S.R.F.K.AS.N..GAL..LAV..SLEP.IGGS...---...--------- EDA12377.1/77-252 PPDSVWESIQVKLGHKAANDTEFVDQTT.NAKPSSDNVVDLEKekqkr..........................................wknlsFISTAAALVL.AVLL....................................................---------FMMQPVPTP....EVSHIAVVNNA.......................--DNTPLWVIE.....VSDT.TMNVKVTDAF-.VALA.DKDYELWMV..pANGEA....P..ISLGLM....-PEVNGDT...RAT...P.D.I.L.LD.Q.sIAA..LAV..SLEA.PGGSvtgAPT...---EVL--- 2001238234/80-188 ----------------------------.--------------....................................................----------.----....................................................---------------LRR....PDAKVVSLAAS......................dVAKGASGVLLY.....NPVT.QKIWLYSANLP.ECPT.GTAYQLWAI...--DQR....P..VSVGTFh..iDAGEMAHL...LVK...R.L.P.E.FE.K..ARK..FAV..SLEP.AGGR...-PQ...PTGPIYLAG EDA77723.1/62-218 PDESLWQKLQQRLGWQKADVVQLKPKGS.WLHPAN-------W....................................................VAVAAAASLA.LVLL....................................................------------LPPLAT....APVELAVIQTK.......................---EAKALWLV.....SKQG.DTVVLQASAAV.LADP.AHDYELWML..pTSGQS....P..ISLGLL....PQSGKVSY...PWP...K.A.A.T.GL.V..VAV..LAV..SLEP.KGGS...-PTg.qPTGAVL--- 2001294195/14-108 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-SNGLTGSVLL.....DRER.NTVALVMWHLP.ELSA.GQTYQAWLI...EADGH....R..VSAGVFq.pqADASYTTQ...PIY...S.K.Q.D.VS.N..FVG..VGV..TVEP.AGGS..dQPT...--GPRIFK- EBZ67954.1/5-119 ----------------------------.--------------....................................................----------.----....................................................-----------LRTPDIA....GERYTVVLQQP.......................GEAAKPGWVIQ....vSSDG.TLSLDPLVA-D.QVPE.GRALQFWTL..iDPADG....P..RSLGLV....EAGQPLRL...PAE...Q.I.G.A.VQ.P..GQL..FEL..TLEP.AGGS...-PYn.rPSGPVLYIG 2001487789/6-164 ----------------------------.--------------....................................................-----AAAVF.LAAGllwtvnknkt................................lenkvstittDKEFLEIQIEDVNSDLAD....TKKLLNVVRDQnlihi............slngqpVYPEGYAQVYW.....DKTL.EKVYLDLAGLP.KPPE.GKVYQIWSL..tLNPLS....P..TSLGTI....EGFNANAN...KIF...E.L.Q.N.TN.D..SQA..FGI..TLEP.AGGS..kTPT...--ME----- 2001345598/4-118 ----------------------------.--------------....................................................----------.----....................................................----------PRPDPKAF....AAELVAALHAE.......................GSNVSFVALYN.....QTSG.QLRVTPLSG--.EQYT.DKDYELWAI...EDGGP....A..KSMGVIa..aNSRQDVKI...SQD...I.L.I.D.FG.E..GTT..LAV..TLEQ.NGGS...-PTg.vAQGPIVAVG 2001494198/21-122 ----------------------------.--------------....................................................----------.----....................................................------------------....----------Ksiini............plegkaAAPGAFANVYW.....DKKD.DTVYLDLQGLP.EPPE.GKVYQVWSL..tLNPLT....P..TSLGTI....DDFIQDDN...KIF...K.L.K.N.AN.Q..SQA..FGI..TLEP.AGGS...-PS...PTLE----- ECN56201.1/61-217 PSAQLWRRIERRIKAPETS-------VA.WWNLLAFWR--GLS....................................................AAGLMASVVL.AALL....................................................-----------LTRPPMP....APSFVVVLMAP.......................QSQAPGWVVQA.....SDNQ.QIQLIPLGVI-.EIPA.DKALEFWTK..gDGWQG....P..VSLGLV....KPGQTLSV...PLD...K.L.P.P.LA.P..NQL..FEL..TLEG.PNGS...-PTg.kPTGPI---- EBF11173.1/80-240 PPPHLARRIEAALFPDAAPAPIRQRIGL.WRG---------LG....................................................LAGVATSVAL.AAIL....................................................----------VLTPRPEP....VAPLVADLAPV.......................TGTVQFVALYD.....PATR.LLSVRQSAG--.EARD.GRAQEVWLI...AGEDA....P..VSLGLI....GENGQLRA...VLP...E.TlA.P.VL.A..GAT..LAV..SDEP.AGGS...-PTg.aPTGDVLAAG ECX57881.1/45-235 PPDSLWNDIEAAVFDDSPSDAMGEESGE.SSTNNVVDITSRFRrg................................................taFFAAAAAAVV.VIVG....................................................------ALVVSASGND--....-SPTFEVVGDArldwqe...........gfvdegLTVTIDATILD.....TGSA.QAVQLNAAAL-.PPRA.GEDLELWLIg.iDAAGE....LtiSTLGTI....ESDTDGTY...EVP...D.D.F.D.SS.A..FDTvlVDI..SYEP.RDGD...-ET...HSGASIVRG 2001304927/13-109 ----------------------------.--------------....................................................----------.----....................................................------------------....-------QNTE.......................QASGASAFVVM.....GANG.NNGVLVVDELP.PLDE.SHEYQVWLV...-KDHT....N..TSGGTFa..vDEDGYRGL...RLD...A.P.D.S.LL.S..YSS..VFV..TVEP.LGGS..aQPS...-SAPVL--- EBF11836.1/45-201 ----------------------------.--PPPRVKATLQRRlfgvgrs.....................................gfspvralLGALAAAAIG.VLVL....................................................-------VFLPGPQPPVT....GPALTAEIAAG.......................---DRSLVVEA.....RLVG.GALEISREAG-.GPPP.GRVLELWLI..aEGAPG....P..VSLGVL....PEDPAATL...PLD...A.E.T.R.AAlA..GAT..LAI..SEEP.PGGS...-PTg.aPTGEVLAAG EBV25338.1/77-243 PPDSVWESIQVKLGHKAANDTEFVGQTT.NSIPSSDNVV---Dlekekq.......................................krwknlsFISTAAALVL.AVLL....................................................---------FLMQPVPTP....EVSHIAVVNNA.......................--DNTPLWVIE.....VSDT.TMNVKVTDAF-.VALA.DKDYELWMV..pANGEA....P..ISLGLM....-PEVNGDT...RAT...P.D.I.L.LD.Q.sIAA..LAV..SLEA.PGGS...---...--------- 2001473491/8-136 ----------------------------.--------------....................................................GAGAIAASLI.IAVL....................................................--------ATDIATPVQD....-GPFVAVFHRD.......................DTQPAFVMTID.....LDTR.AVTIRPVEA--.SLPE.GKTYQLWIKs.dQSDSV....P..QSLGLLq..nASVATTKN...LGQ...F.D.P.A.ML.R..TAT..FGI..SLEP.EGGS...-PTg.qPTGPAI--- 2001445009/62-176 ----------------------------.--------------....................................................----------.----....................................................-------------TNLKE....SKELISILRDRhiiav............plagqaISLNAYAKIYW.....DKST.KTIYLDAQGLP.EPPE.GKVYQLWSL..tLEPLT....S..KSLGTL....NDFDSVTN...KIF...T.L.K.N.AN.A..SQA..FGI..TLEP.EGGS..iTPT...--------- ECD17777.1/3-73 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----------.....----.-----------.TVPA.GRALQVWTL..wNREVG....P..RSVGLL....DRARATPL...DLQ...Q.L.P.T.TA.A..DQL..FEI..TLEP.AGGS...-PTg.rPTGPILYKG ECT06564.1/3-131 ----------------------------.--------------....................................................--AFAASLAV.AAVL....................................................-----TAPNLR---PPPA....EPTLNALVAAE.......................DRTLVIEAALF.....AEAG.ELRIARTAG--.AAPP.GRVLELWVI..aDGATA....P..VSLGVL....PDAAEATL...DLP...A.D.RaA.LL.R..GGI..LAV..SDEP.PGGS...-PTg.aPTGTVLATG 2001431388/1-102 ----------------------------.--------------....................................................----------.----....................................................------------------....----VAVFQHD.......................DQQPAFLLTVD.....LQNR.QLNIRPVTA--.EPQP.GKSYQLWIKs.dELGPN....P..RSVGVLg..dQMQLDKGA...LKQ...Y.D.P.A.LL.R..EAT..FGI..SVEP.PGGS...-PTg.qPTGPAI--- EDJ23603.1/8-126 ----------------------------.--------------....................................................----------.----....................................................-----LAAILVLTPRPEP....LAPLVADLAPV.......................TGTVQFVALYD.....PATR.LLSVRQSAG--.EARA.GRAQEVWLI...AGEDA....P..VSLGLI....GENGQLRA...VLP...E.TlA.P.VL.A..GAT..LAV..SDEP.AGGS...-PTg.aPTGDVLAAG ECW17711.1/78-225 PSAAVKTRLMAEIAGEAEPSRGRGWR--.-------------W...................................................lAIPSAAALVA.AAFL....................................................-------TLSPILRAPAF....EPAFEATLASE.......................D-RAVVIRAAF.....APEG.NLLRVTPETG-.RPAP.GRDFELWII..aEGADA....P..VSLGVI....AAEAETTV...TLD...AaR.A.A.LI.A..GGT..IAV..SDEP.AGGS...-P-...--------- ECK62886.1/73-248 --------IRLAMPSGKFARSVVEPKHT.--SQRDWMKHAASW...................................................sGWVTAALMLI.AFLG....................................................RDLKNRPQIIQLTPNEAR....AQLLATV-EDSlqvdw............tvtedeAARSAAGDVVW.....SNTA.QEGFMRFTGLAaNDPS.QSQYQLWIFdsqQDERY....P..IDGGIFd.ipPGGDEVVV...PIA...A.K.L.D.VA.R..PYM..FAI..TIEK.PGGV...---...--------- EBD82099.1/70-270 -PEELKDQISARAKDFHQPVDKEVAIGE.ANARGEDVEEKEENivrps.........................................fwsrpaIGWAAAAVLA.LLLI....................................................-----AQDSPDGGGGAGS....PSLVEQVESDPallrr............tfsgagEEAASVGEVLW.....SDTQ.QQGVMLLGGLPeNDPT.VSQYQLWIVdptRDDVH....P..VDGGVFdipaSASGLVAV...PIA...A.T.L.P.IA.N..PAA..FVI..TVEQ.PGGV..vVSK...-QEQVV--- EBC77628.1/16-155 PPANVWESIQIKLGHKAANDAGIATGVN.TPSDSGQV-----Ldfekekq......................................krwknlsFLSTAAALVL.AVLL....................................................---------FVMQPMPAP....EVSHIAVVNNA.......................--DNTPLWVIE.....VSDE.TMNVKVTDAF-.IALA.DKDYELWMV..pANGEA....P..ISLGLM...pEANGD---...---...-.-.-.-.--.-..---..---..----.----...---...--------- EDH17579.1/66-248 -PDHLQQQIRLAMPSGDFTRSVVEPTHTsQRDWMRHAA---SW...................................................gGWVTAALILI.AFMG....................................................PSFKNRPQVTQLTPNEAR....-AQLLATVDDSlrvdw............tvtdaeAARSPAGDVVW.....SNTA.QEGYMRFTGLAaNDPR.QSQYQLWIFdsqQDERY....P..IDGGVFd.ipPGADEVIV...PIA...A.K.L.D.VA.R..PYM..FAI..TIEK.PGGV...---...--------- 2001470601/6-76 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----------.....----.----------S.APPA.GRVTELWAI...APDAA....P..VSLGVV....PLEGEWQI...TLP...E.N.L.RaVA.A..SLT..LAL..SDEP.TGGS...-PTg.aPTGTVLAA- EDI21112.1/89-249 ----------------------------.-------------Atqii...........................................silpwLGWAVAACLV.ISLNipdtd..........................................tslpaIQLTSTQKLEALIKKEPS....SQRLAFSSASD.......................PYQNISGEVIW.....NDGL.QEGYMSLTNLPvNDPT.QNQYQLWIVd.pERDEL....P..VDGGVFd.ipAGSKTAVI...PIR...N.A.L.H.VS.K..PAA..FVI..TLEQ.PGGV...VNS...-KQEVVV-- 2000461410/66-228 ---RVWQQLEQELKLKPTKLSFWER---.-------------Fqts..............................................lnwALPSLAAIIA.AVLT....................................................---------AFLLNQPKP....PQAYVAALKSP.......................QQQNSLVLAMA.....KHDEmKISFEMLDQHL.EKQQ.GMVATLWCIs.kNKNEP....P..MRMGTL...eQTKQEIAL...NPN...M.W.K.G.LA.S..ASE..FAI..SLEP.QTAN..iA-T..qPQGKIILSG EDJ57470.1/158-324 -----------------------APAAA.SRQRGD-------Rsre..............................................afaWMAAAAALLV.AVIG....................................................-WLPAWQMRPQLPPTVTV....ASQRAALLAEGgasvvqla......waatddeavLDGDDLGDVVF.....DPAT.QEGYMRFRGLAaNDPS.QQQYQLWVFdaeQ---De.ryP..VDGGVFd.vsAGSDEVIV...PIH...T.A.I.A.VK.E..PTL..FAI..TVEK.PGGV...---...--------- EBF92636.1/47-246 --AELANKIRRDAAAHLPQAMPGEARLE.-ARSETRSTR---Gqsw..............................................laaGWWAAACLAG.VVLWqwsgqpkvpiaa............................egtpsltelrsqLLATDPAAVTVAWKRASD....DPSLVAGEAAL.......................EVVGGLGDVVW.....SAAR.QQGFMRFRGLA.ANDPsKAQYQLWIFdaeRPGDY....P..VDGGVFdvpqTAAGDVLV...RID...P.R.L.P.IS.R..ATA..FAI..TVEQ.PGGV...---...--------- 2001078020/8-149 ----------------------------.--------------....................................................WGSAAAAAAA.LVVG....................................................--YLSAPLLERGPGAGGRfdpgAPVLVASLPVG.......................SETGPRLGLTY.....LPRS.SDLVVEAAGV-.AGDG.THDHELWLV...VPGTG....P..LSMGVI....APGKQARV...HLP...P.E.L.A.AR.V..TAG..LDVvlTREP.LGGA...-PAg.gVAGPVVASG 2000222610/6-147 ----------------------------.--------------....................................................WGSAAAAAAA.LVVG....................................................--YLSAPLLERGPGAGGRfdpgAPVLVASLPVG.......................SETGPRLGLTY.....LPRS.SDLVVEAAGV-.AGDG.THDHELWLV...VPGTG....P..LSMGVI....APGKQARV...HLP...P.E.L.A.AR.V..TAG..LDVvlTREP.LGGA...-PAg.gVAGPVVASG EBB60714.1/45-202 PPADLWNDIEAAVFADSPSDTVGEESGE.SPTNNVVDITSRFRrg................................................taFFAAAAAAVV.VVIA....................................................------ALVVAASGNDSS....SFEVVG---DArld................wqegFVDEGVAVTVDatilgTDSA.QAVQLNAAAL-.PPRA.GEDLELWLIg.iDAAGE....LtiSTLGII....ESDADGTY...EVP...D.-.-.-.--.-..---..---..----.----...---...--------- 2001236632/104-268 ----------AELARQANEASRQTTSQP.RESRSWRWLR---Vg.................................................ieITIAIA--LA.VVIGqf...............................................igrGQQTAEATPPALDPSTPV....GRIRFSDFNFF.......................-----------.....--MD.RISITLNNNVP.RPEE.GTHYETWLI..tDDGQT....A..RKIGPVt..yGASGVGRL...EFNnpsQ.D.N.L.LR.D..YNE..IQI..TMEQ.NGTSi.tSPT...--GEVLFS- 2001371310/59-253 ----------------------------.-------------ElrrngngsdqpstlttgngageeaatngrqrsfieainanlddedgqrrrsiATGAAAVVAFvVIVGivlwvtsrlndaagrvaa................aeqqvatttrlasdqvqaARDDANRQITEARQLAQR....AETVSAVLTAPdlirf.............nltstQSDGSSAQVLW.....SRSR.-EVVLSGTRLP.GPGP.KKTYQLWLV...-TNGP....S..VSAGVF....NPN-----...---...-.-.-.-.--.-..---..---..----.----...---...--------- EBB35623.1/9-91 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................------GNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- 2001267199/30-115 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----------.....----.DQVTVSTSSLE.APPQ.GSRYEAWLI..qDDGEQ....R..ISIGVIafdqQNQGSLAF...VAG...D.G.Q.NlLG.K..YRT..LEI..TREPdPDPS...-PN...SSNDVAFSG EBS03824.1/87-170 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- EBT03550.1/145-228 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- EBS05116.1/150-233 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- EDJ44180.1/115-298 ------LAIEAAATV-------------.-------------Gatlpssggagsspgf.....................dlpdrgpgraspiglpWILAAASLLV.AVLG....................................................---WMQAWSLPFEPSPAA....ARARLVAGEGDevlrlp..........wtstddpAAAAASGDVVW.....STKG.QQGYLRFRGLP.ANDSrVEQYQLWIF...-DGQQderyP..IDGGVFd.ipPEGGEVVV...PIR...P.A.I.R.VA.Q..PTM..FAV..TIEK.PGGV...---...--------- EBR97649.1/176-259 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- ECZ08781.1/177-260 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- ECU87114.1/175-258 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDPT.QNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTGDAPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.PGGV...---...--------- 2001218610/36-121 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----------.....--PA.DQVTLTTSSMP.LPSE.GNQYEAWLI..eDDGEQ....R..VPLGFItfteDARGTLTF...VDP...Q.G.R.N.LL.G.mYHG..LEI..TVEPnPDA-...NPI...PSNTVAY-- ECZ06058.1/41-123 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................------GKVIW.....SDDG.QRGFITLAGLPmNDSS.KNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTTESPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.TGGV...---...--------- EDA11315.1/162-245 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGNVIW.....SDDG.QRGFITLAGLPmNDSS.KNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTTESPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.TGGV...---...--------- ECO30414.1/147-230 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................-----SGKVIW.....SDDG.QRGFITLAGLPmNDSS.KNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTTESPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.TGGV...---...--------- EBT54878.1/144-226 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................------GKVIW.....SDDG.QRGFITLAGLPmNDSS.KNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTTESPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.TGGV...---...--------- EBS81057.1/155-237 ----------------------------.--------------....................................................----------.----....................................................------------------....-----------.......................------GKVIW.....SDDG.QRGFITLAGLPmNDSS.KNQYQIWIVd.pNMHAN....P..VDGGVFd.ivTTESPTII...PIN...P.K.L.P.IG.K..AKG..FAI..TLEQ.TGGV...---...--------- #=GC PP_cons 9999**9999999998777777665555.44444444444442....................................................6666666666.6666....................................................777777777777777777....88888888888.......................77788889999.....9999.99999999999.8889.*********...99999....*..******....88888889...999...9.9.9.9.99.9..***..***..****.***9...688...999999886 #=GC RF 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