# STOCKHOLM 1.0
#=GF ID TIR-like
#=GF AC PF10137.10
#=GF DE Predicted nucleotide-binding protein containing TIR-like domain
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF GA 24.7 24.7
#=GF NC 24.6 24.4
#=GF TC 24.7 24.7
#=GF SE COGs (COG4271)
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF DR INTERPRO; IPR019302;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Members of this family of bacterial nucleotide-binding proteins
#=GF CC contain a TIR-like domain. Their exact function has not, as yet,
#=GF CC been defined.
#=GF SQ 50
A0A1M6RB85.1/119-237 KIFIVHG.HDDGIKNEVARFLEN.LG.LEPIILHE....QSSSG-DTIIEKIERY....SN-VGFGIVLYTPCDKGGVAKEp..............idLNFRARQNVVFEHGYLIGKIGRKNVV.AL..V...............KETVEKPNDISGVVYVSYD-
A0A1D2R3G6.1/130-249 KVFIIHG.HDEGTKEKVARFLMQ.LK.LEPIILHE....KPNEG-KTIIEKFEKH....SFDAGFAIALLTPDDVGNSRVNe..............knLTYRARQNVILELGYFIGKLGRKRVC.AL..L...............GKDVEIPSDYSGILYIPLE-
A0A1D2R754.1/115-248 KIFIIHG.HDKGTKNTVARFLEN.ID.LDPIILHE....QPNEG-KTLIEKLEKH....LLDAGFAIALLTPDDVGAEASElesklneknyekffkeiLKPRARQNVIFELGLFIGALGRNKVC.VL..Y...............VKNVEILSDYEGVLYIPLD-
A0A3P7P6T2.1/136-253 KVFIVHG.RDDLAKVEVARFVEK.LG.LEAIILHE....QASSG-KTIIEKIEEH....TN-VGFGIVLYTPCDVGGLKGEt...............dLKARARQNVVFEHGFLMGKIGRSNVC.AL..V...............KSNVEKPNDISGVVYIGMD-
D0LNL0.1/453-570     KVFVVHG.HDKGVRESVARFLEK.LG.FDAVILNE....RPDQG-ATIIEKFERE....SKGVCFAIVLLTPDDVGGRIGD................dSQLRARQNVIFELGFFVGKLGRGRVA.LL..R...............KGDVEMLSDYHGVVYREHD-
A0A371WXZ5.1/154-270 RIFIVHG.HDDGARETVARFLER.IG.FEAVILHE....QANRG-RTVIEKVEAN....SD-VSFAVVLLTPDDEGCVKGG................aVEPRARQNVLLELGYFIGKLGRANVC.AL..K...............KGVVEIPSDFAGVVWETMD-
R5V068.1/111-227     KVFIVHG.HDTNLKLEVARLLEN.QG.IEAIILHE....QVNAG-MTIMEKIESY....GNTVNAAIILFTPDDDGKAKKEe...............vLKNRARQNVVFEAGYFAGLLGRNRTI.FI..V..............sDDSMELPGDLNGIIYN----
A0A257LY44.1/70-190  KVFVVHG.RDNETKQEVARFIEK.IG.LQSIILHE....QASVG-MTIIEKIERY....SNDADFALVLYTPCDRGRGAHEtt.............vpARDRARQNVVFEHGYLMAKLGRENVC.AL..V...............KGEIETPNDISGVVYVGFD-
A0A0A7EKQ8.1/187-305 KVFIVHG.HDDLAKEQLARFVSQ.VG.LVPIILHE....QASSS-KTIIEKIEKY....ADEVCFAIVLYTPCDVGAKAGVt...............aLSPRSRQNVVFEHGYFIGKLGRENVT.AI..V...............KGDLEKPNDISGVVYETLD-
A0A1T5J3D9.1/205-321 -IFIVHG.HDDLAMNEVKVFLLE.IG.FNPIVLRE....QPNEG-QTIIEKIEKY....TN-VGFGIVLYTPCDEGKAKEQa...............eYRNRARQNVVFEHGYLCAKLGRNHVC.AL..V...............KGDLEIPGDLGGVVYTPMS-
Q8EDI5.1/128-248     KVLIVHG.HDEAAKYRTEAFLRK.HG.FDPIILHL....NASKG-DTIIKKLERL....AEGVGYGIVLYTPDDMGETKVKav............qheLQPRARQNVVFEHGYLMGLIGRPNVA.AI..V...............EGYVEKPSDIDGVVYIPS--
Q54F65.1/55-183      KVFIVHG.HNNIVREKVSKFLFE.MG.FEPILLFE....KPNNG-QTIIEKLEKE....ISNCKFGIVIMSPDNKAFTKKDsns...........dyvEIAYPRLNVVFEFGYLIGKFGRSNVI.YL..Svpy.........ngkSQNYDLPSDLLGYVWINYT-
A0A1D2QYR7.1/214-332 KVFIIHG.HDEGTREKVARFLMN.IN.LEPIILDE....QPDEG-QTIIEKLEKH....SVGAGFAIALLTPDDVGAPKSNi..............dnLRDRARQNVILELAYFMGNLGRKRMC.IL..-...............NKGVEIPSDYSGILYIPLD-
Q9A4X3.1/154-273     RVFVISSvEALPIARAIQTAFE-.YDpFTVIVWTD....GVFKVANYTLQSLEDE....IDNSDFAIAIAHPDDKVESRQA.................QWPQPRDNVIFELGLFMGRLGRARAI.LM..Ep.............rDEKVKLPSDLAGVTTIGY--
A0A1Y1S9P9.1/93-211  KVFIVYG.HDTEARDQLELMLLR.MN.IKPVILGN....MTPDG-KTIIEALIAS....TD-VPYAVVLLTPDDEGHKANAd..............aeKKFRARQNVVLEMGMFLAKLGRERVA.IL..H...............KGSLELPSDINGLIYIPFE-
A0A1M5D273.1/130-243 RIFVVHG.HDSELKESVARWIAK.LG.YEPIILHE....QANVG-RTIIQKFRDE....AADVGFAIVLLTPDDELPN---.................GKKRARQNVILELGFFLGALGPNRVA.SL..V...............RGDVETPNDFDGVLYTPVD-
A0A142LNX0.1/127-245 RVFVVHG.RDELLKTKVARFIER.LG.LEAIILHE....QANKG-MTIIEKIEAT....TD-VDFAVVLYTPDDSGNLAVLaa............qgqLNERARQNVVFEHGYLIAKLGRAHVV.PL..L...............SSRVEVPSDISGVVYVD---
C1F5N0.1/154-273     RVFIISSaEALDIARTIQNAFDH.DP.FNVTVWTD....GVFRASHYAIESLERA....LDQSDVAIAVAQPDDITESRGQ.................QRATPRDNVIFELGFFMGRLGRHRAL.LV..Ep.............rGEEISLPSDLAGINTITY--
Q98RD6.1/91-211      KVFIVHG.HDKIALLELKDLLRD.LK.LNVVISQN....KTTRG-LSILDGVLED....ISSVSFAFDLLTPDDKGYSNLDge.............skTLPRARQNVIFEMGMLYGKLPKNKIM.IL..N...............KNDVELPSDINGMIYKSFK-
A0A0N0V0K2.1/97-221  -VFIVHG.HDDTAREQLELILHK.LG.LEPFVLAN....SGALG-LTIIEALESKigknSTVTAFGIVLMTPDDMGYAMSAgg.............deVQPRARQNVVLEMGMLISSIGRKNMA.IL..V...............KGHIEKPSDADGILYIPFNN
I4BA92.1/15-128      KVFVSHG.RSPLW-NEVERFVRTqLE.IDVVILKD....QVNRG-RTVIEKLEEE....TDECHYAIIVMTAEDEQAD---.................GTIRARQNVVHEIGFFQGKFGRENVL.VL..R...............QDSVEEFSNIAGIVYEPFS-
I4BAC8.1/15-127      KIFVSHG.RSSLWQ-EVERFVRTqLE.IDVVILKD....QVNRG-RTIIEKLDEE....TDECHYAIIVMTAEDEQAD---.................GSIRARQNVVHEIGYFQGKFGRENVL.VL..R...............QEPVEEFSNIAGIVYEPF--
A0A2U0S0S9.1/114-235 KIFLVHG.NDTEMKNDATQTLQK.LE.LDPIILHE....TKNNQ-QTLIEKITEH....NH-VSFAVVLLSPDDLAYPKEKtp.............neAKQQAKQNVIFELGYFLGRLGKQNVV.AI..Yr.............kKKDFEVPNQYNGVLWIEYK-
C5BHR5.1/5-124       RLFIASSsESLAIAEAVNVNLD-.HE.FEITVWKN....GTFKLSSSTIDDLVEK....SSFVDFALFIFAPDDISEIRSR.................KEHVVRDNVIFEMGLFVGAIGKSRSF.IL..Kp.............rGIEMHLPTDLLGVTPADYD-
A0A496AYZ0.1/9-129   KVFISHG.NDEEAITTVAKFVEN.LG.LRATVLDV....QTTNG-LTAIENLEKY....SDDTEFAIALLTPDDVGAFKDEag.............rqLKPRAHQNVIFELGYFIGKLDPNRVC.LL..Y...............KEGIELPSYIPKLVYVPMD-
F8B4J3.1/196-327     NVFVVHG.RDTGARDAMFAFLRA.VG.LRPIEWNEa.vrATGHPTPYIGEILTTA....FASAQAIVVLLTPDDDARLAPAfwrpdd.....ppheraYTGQPRANVLFEAGMAMAVDARRTVL.VE..-...............VGRVRPFSDIAGRLVLHLN-
A0A3A9HPY2.1/222-342 -VFIVYG.RDNDLYNFVLTFLKM.TD.AKAISLAE....TGPEGSKTIIEQLENH....IREAKYAIVLLSPDDIGYLATGnv.............deKEKRARQNVLIEYGYTLGFLGRQNVI.SI..S..............vDSSLDLPTDLHGIRFIPL--
Q9X882.1/76-206      -VFVVHG.RDDQVRREMYELLRR.LD.LRPKEWEDl.vrATGQASPFLGDVVAGA....PAQAQAALVLLTPDDVVTLHPElrghne.....pdhetrPVCQPRPNVLIELGMVLMAYPERTLI.VE..-...............VGGVRPIADIAGRNVIRFD-
Q027G3.1/4-122       RIFIGSStEGLPHACHIKELLTS.FGdIEPVLWTE....IFHPG-LLTFEALENV....LLRCCAAVFVASADDVTTFRGQ.................CIHTPRANVMLEFGLVAGRIGRHSIA.LC..L...............AGGAQLPSDLQGLTVIDMS-
C7PYD3.1/410-539     -VFVIHG.RDERARVATFDLLRA.FG.LHPVEWDEa.vgLLQQPMPFLGRVLREA....IPRAKAVVVIMTPDDIVRLHPElagpse.....pgfetgHSMQARPNVLIELGMALAYHPRATLI.LQ..-...............VGDHRPIADLGGFNYVRV--
R5R263.1/4-123       RIFIGSSkESVKIAEKVKSLLD-.GE.YVCQLWCD....NFFDLGQCTYHELLKK....SLSFDYAIFIGGKDDYVRRESDr...............tHKYAARDNVYLEFGLYAGILTYARCF.FL..I...............QEGCQIASDLLGVNVVFFD-
Q3SKL0.1/129-241     RVFISHG.RAPDWR-EVQAYVEKdIG.LPTLELAQ....EPNQG-RTILAKLMEA....SGQCDSAVIVMTGDDLDAA---.................GQARARENVIHEIGFFQGKYGLGRVC.LL..H...............EEGVSIPSNIHGLVYTPF--
A0A1L3GMV6.1/213-329 RVFVSSSiEGLHIAETIQADLE-.AI.AECTIWTQ....EISSE---NFENIVNI....AADFDYAIIVLTVDDILIKNET.................ERLGPRDNIVFELGLFTGTLGRAHTF.MVlcK...............DDPIHLPSDLVGVTVAMYS-
A0A1G9BV43.1/242-354 -VFIGHG.GNKQWR-ELKDHLSD.LHnIKVEAFES....GARAG-HHIRDILEDM....STKSTFAIMVMTGEDETKD---.................GKMRARQNVIHEIGLFQGKLGFNRAI.VA..M...............ENDTEEFSNINGVQQLRFS-
A0A1M7QQY0.1/167-297 RVFLVHG.RDLAKRDSLTALLRA.FD.LRTITWSEa.eaATGVATPYTGDVVIAG....MDAADIVVVLLTPDDLGQLSPEfiqvnd.....gpeerqPSGQPRMNVIFEAGMAMARS-RNSVI.FV..E...............IGKIRPMSDITGLNVLRL--
A0A1M5GEF6.1/156-269 KIFLGHG.GAPDWRELQADLRDK.HD.IDIIAFES....GAREG-HAVRDVISEM....LQSADFALLVMTAEDEQSD---.................HTFRARQNVIHEAGLFQGRLGYHRAI.LM..V...............EEGVEHFSNVAGIVYMSFE-
A0A402CY17.1/158-248 RIFIMSSvESLDIARAIQNGLE-.YDpYLVVVWTD....GVFRASSYPIDALEGE....VDQSDFAIAIAHADDVTHTRGK.................TWPTARDNVVFELGLFIGRL------.--..-...............--------------------
A0A150L6V4.1/9-138   -TFIGSSrEAKKLVAAVHSQIK-.YH.TEVTPWYN....AFPAN-EYTMEALEKE....LNESDFGIFVFAPDDIALHRGK.................YVYIPRDNTIFEAGLFWGKLGRGRVF.AI..IpeqvkerddliigatVNEFHLLSDLQGLTLLSY--
A0A1U7CSF3.1/16-139  RVFIGSS.SEYLHVAEVAQHLID.AT.ATAEVWNV...sPEFKQTQSTLDGLLSA....IERYDYAFFILSLDDRLTIRAR.................KTVSVRDNVLFEFGLFLGQLGADRVA.AI..Mqt..........ptaDVEARIPADLEGITITRFR-
A0A1M7RDS6.1/5-115   -------.EGDDLARAAQINLD-.DD.CEVATWRQ....APSALSQIIIGHIEDW....LRKSDFCLIIMTADDQVRSRGR.................QMAAMRNNLLLEIGMSIGIVGRERTI.LL..Cd.............rNNPPVLPTDLGGITVVTF--
A0A0K2SQW1.1/236-348 NVFIGHG.RSAIWR-DLKDFIQD.RL.HLPWDEFN....RIPVAGITNIARLSEM....LDAAAFAFILMTAEDEQSD---.................GTVRARMNVIHEAGLFQGQLGFTKAI.IL..L...............EEGCEEFSNIHGLGQIRF--
B5JSV8.1/10-59       -------.---------------.--.--------....----------------....--------------------EN.................VQPRARQNVVLEMGMLISAVGRGNVA.IL..K...............KGHLEAPSDAQGILYVPFN-
I4B6T0.1/39-147      -IFLAHG.EESSWH-EVAEFIEQkLA.HEVVPYAG....SLAPG-RTDIQKLEEL....TEECAFAIVMLTAKESAA----.................---RSRAKIIHEIGFCQGSFGRENVL.VM..K...............EEGAQEIEELGGVIYVPFA-
R6AWR2.1/24-129      -------.-----VEYIQNKLGD.RG.ILCFDWRSlfsrAHNMEQIALLPALMKK....IPTFDFALIVAEGVDTVKLRGS................eERSAIRDNVIFELGLCTMALGAERVI.LL..A...............EENVRIPEDLIGVG------
Q54R22.1/123-226     -------.-NNEIQEKYSKMLED.MN.ISIVLLES....--KNG-KTDIKNFEKI....IDGCDFCLVFVTYDLESHD-PEy...............eEHYYPRFNLIFEMGLLYGLMGKNNTI.YV..Dla..........pkgNKLHDFIADI----------
Q54KI8.1/3-88        -------.-------------IK.LK.IDMIIVPQ....NDNSEFTKSIDTIEKE....VKKCDFCIILITYENRFFKKTNnff..........eayqEMVQPNLSLLLEMGYLISHFGKQKTI.IV..E...............--------------------
A0A1D2QYM5.1/3-92    -IFVSHSsKDNEFIDVIRSIMKK.IG.VDFYQVET....DMCSS--TIYEQIREY....VNISSAVVVILTSNVIDNK---.................---TTRDNVLFEIGAAYALHKDIYIF.VE..-...............--------------------
R6H898.1/7-67        -------.---------------.--.--------....----------------....-----------GKDDLSVRLKSr...............kVKISPRDNIYLEFGLYAGILSPARSY.FL..I...............DEKCKIASDLLGITVLRYS-
A0A1G5MFZ8.1/7-123   -IFVVWG.GNRVLASAVVDRLRK.AGrTAVLGGDE....RVPNQSSFLGERVRQQ....IMTAGAVLVLVEDTQCNRL-PHf..............paSGPAFRPNMMFEWGLALATLPRNLVSpAL..I..............gINRSELPNDLVGIW------
A0A1Y1S9V5.1/55-122  -------.---------------.--.--------....-DVSGSPNIPQTILAK....IQEADVFVCDITTINSSVT--S.................GRKVPNPNVVFELGFAAALLGWQRII.LL..F...............NESV----------------
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