# STOCKHOLM 1.0
#=GF ID   TIR-like
#=GF AC   PF10137.10
#=GF DE   Predicted nucleotide-binding protein containing TIR-like domain
#=GF AU   COGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   COGs (COG4271)
#=GF GA   24.70 24.70;
#=GF TC   24.70 24.70;
#=GF NC   24.60 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF DR   INTERPRO; IPR019302;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family of bacterial nucleotide-binding proteins
#=GF CC   contain a TIR-like domain. Their exact function has not, as yet,
#=GF CC   been defined.
#=GF SQ   49
#=GS E3J264_FRAIE/144-263      AC E3J264.1
#=GS B4S624_PROA2/362-481      AC B4S624.1
#=GS Q8EDI5_SHEON/128-249      AC Q8EDI5.1
#=GS R5IEF5_9BACT/151-269      AC R5IEF5.1
#=GS B0UTQ9_HISS2/135-254      AC B0UTQ9.1
#=GS D5V4Y7_ARCNC/166-284      AC D5V4Y7.1
#=GS Q6D353_PECAS/127-247      AC Q6D353.1
#=GS A1SX31_PSYIN/148-267      AC A1SX31.1
#=GS Q47ER9_DECAR/134-252      AC Q47ER9.1
#=GS R5V068_9FIRM/111-228      AC R5V068.1
#=GS A0A0F7REG3_BACAN/128-251  AC A0A0F7REG3.1
#=GS Q21MV2_SACD2/143-262      AC Q21MV2.1
#=GS I3UFW1_ADVKW/147-263      AC I3UFW1.1
#=GS D0LNL0_HALO1/453-571      AC D0LNL0.1
#=GS B0UF11_METS4/156-275      AC B0UF11.1
#=GS Q2K8S5_RHIEC/205-324      AC Q2K8S5.1
#=GS B1ZZI8_OPITP/123-242      AC B1ZZI8.1
#=GS F0ZMV3_DICPU/57-185       AC F0ZMV3.1
#=GS TIRC_DICDI/55-184         AC Q54F65.1
#=GS L0HBG8_METFS/245-360      AC L0HBG8.1
#=GS C4ZIE6_THASP/167-285      AC C4ZIE6.1
#=GS Q027G3_SOLUE/4-122        AC Q027G3.1
#=GS R5R263_9FIRM/4-124        AC R5R263.1
#=GS C6W705_DYAFD/4-121        AC C6W705.1
#=GS B9TGA1_RICCO/4-125        AC B9TGA1.1
#=GS C5BHR5_TERTT/6-125        AC C5BHR5.1
#=GS Q12JL6_SHEDO/5-125        AC Q12JL6.1
#=GS A5I3L4_CLOBH/140-260      AC A5I3L4.1
#=GS Q7MKB6_VIBVY/8-129        AC Q7MKB6.1
#=GS Q8TKX7_METAC/9-127        AC Q8TKX7.1
#=GS C1F5N0_ACIC5/154-273      AC C1F5N0.1
#=GS B1M988_METRJ/155-274      AC B1M988.1
#=GS Q9A4X3_CAUVC/154-272      AC Q9A4X3.1
#=GS J9R4G8_RIEAN/5-130        AC J9R4G8.1
#=GS D4LTG4_9FIRM/2-122        AC D4LTG4.1
#=GS Q24ZU3_DESHY/13-134       AC Q24ZU3.1
#=GS K0AW63_CLOA9/134-254      AC K0AW63.1
#=GS D5C5H2_NITHN/120-239      AC D5C5H2.1
#=GS I4BA92_TURPD/15-129       AC I4BA92.1
#=GS Q6AL85_DESPS/128-241      AC Q6AL85.1
#=GS C1DBI6_LARHH/98-222       AC C1DBI6.1
#=GS E1W054_GLUAR/175-307      AC E1W054.1
#=GS F8B4J3_FRADG/196-328      AC F8B4J3.1
#=GS C7PYD3_CATAD/410-541      AC C7PYD3.1
#=GS V6KJV2_STRRC/56-188       AC V6KJV2.1
#=GS Q9X882_STRCO/76-207       AC Q9X882.1
#=GS Q8XW61_RALSO/85-207       AC Q8XW61.1
#=GS Q98RD6_MYCPU/91-212       AC Q98RD6.1
#=GS R6JZ57_9CLOT/29-145       AC R6JZ57.1
E3J264_FRAIE/144-263                 .IFLVHG...RDNAARLQVQRVLEK.ATPLEVIVLAD.....QPNSG.QTIIEKLEGH...FENSAFAVILMTAD....DEGRL................KGSAD..LQSRARQNVILELGYAAAKLGRRNVA.IL..F....EDGVEMPSDFHGVGRTLFDS
B4S624_PROA2/362-481                 KVFVVHG...HNVDARDAIEKYLED.LD.LEPITIAK.....QPHEG.QTIIDKFTSN...AD.VAFAIVLLTSD....DNCTE................NHNG.SSPRLRARQNVIFELGFFLGRLDKKNVA.ML..I....KGDIEKPSDIEGIGFTVMED
Q8EDI5_SHEON/128-249                 KVLIVHG...HDEAAKYRTEAFLRK.HG.FDPIILHL.....NASKG.DTIIKKLERL...AEGVGYGIVLYTPD....DMGET..K............VKAVQHE.LQPRARQNVVFEHGYLMGLIGRPNVA.AI..V....EGYVEKPSDIDGVVYIPSS.
R5IEF5_9BACT/151-269                 NVFIVHG...HDNGLKNEVARFITD.MG.YNPIILHE.....QPNRG.KTIIEKIEAF...SK.VCFAIILYTPC....DKGAS................KDSHD..LLPRARQNVVFEHGYLVGKLGRERVC.AL..V....KEEVEKPGDVDGVVYIMYDD
B0UTQ9_HISS2/135-254                 KVFIVHG...RDNETKQEVARFIEK.MG.FEPIILHE.....QSSLG.MTIIEKIEKY...TN.VGFGIVLYTPC....DKGYE................KDSPKE.IKSRARQNVVFEHGFLISKLGRNNVC.AL..V....KDDIEKPNDISGVVYITFDS
D5V4Y7_ARCNC/166-284                 QVFIVHG...HDSVTKMEVSDFVKE.LG.LEPIILHL.....QASSG.MTIIEKIEKY...TN.VGYALVLYTPC....DIGTK................RDSLI..YKRRARQNVVFEHGYLLAKLKRERVA.AI..V....KDELELPNDMSGLVYISYDE
Q6D353_PECAS/127-247                 KVFIVHG...RNNEVKQEVSRFISD.LG.LEPIILHE.....QANVG.MTIIEKIERY...TNDADFALVLYTAC....DLGRG................GDEPNP.PKFRARQNVVFEHGYLMAKLGRENVC.AL..V....KDNIETPNDISGVVYVPLDN
A1SX31_PSYIN/148-267                 QIFIVHG...HDDSAKLEVARFIEK.LG.FEPIIIHE.....QPNAS.KTIIEKIEAF...SN.VGFGVVIYSPC....DIGGK................NKDNPE.LAGRARQNVVFEHGFLIGKLGRSKVC.PL..V....TGNVETPNDISGIVYTSMDT
Q47ER9_DECAR/134-252                 KVFIVHG...RDDLAKTEAARFIEK.LG.FSAIILHE.....QASSG.KTIIEKIEAH...TN.VGFAIVLYTPC....DIGGL................ASEKA..QKSRARQNVVFEHGYLIGKLGRHNVC.AL..V....KGDVEIPNDISGVVYVPLDS
R5V068_9FIRM/111-228                 KVFIVHG...HDTNLKLEVARLLEN.QG.IEAIILHE.....QVNAG.MTIMEKIESY...GNTVNAAIILFTPD....DDGKA..................KKEEVLKNRARQNVVFEAGYFAGLLGRNRTIFIV..S....DDSMELPGDLNGIIYNK...
A0A0F7REG3_BACAN/128-251             KVFIVHG...HDDNLKQQLEIFLNS.IG.IKPVVLHR.....EANEG.LTVLEKFEKH...SD.VQYAFVLLTPD....DIGCSVKE............RAKSVEE.YSFRARQNVIFELGFFIGKLGRAKVC.TL..Y....KDGVELPNDISGLVYQKVND
Q21MV2_SACD2/143-262                 .VFIVHG...HDDAAKVTVARFVEK.LG.LKAIILHE.....QPDKG.QTIIEKFESN...ASNVGFAIVLLTPD....DIASS................KATPED.TMPRARQNVVLELGYFCGSLGRDKVC.VL..Y....KDEVEIPSDYLGVIYMPFGS
I3UFW1_ADVKW/147-263                 RVFLVHG...HDEAVRETVARFIEK.LG.IEVIILHE.....QANSG.RTIIEKIE.W...HSGVGMAVVLLTPD....DVGGK..................TGED.LKPRVRQNVLLELGYFIGVLGRDKVC.AL..K....SGNVDIPTDFAGVVWTEMS.
D0LNL0_HALO1/453-571                 KVFVVHG...HDKGVRESVARFLEK.LG.FDAVILNE.....RPDQG.ATIIEKFERE...SKGVCFAIVLLTPD....DVGGR..................IGDD.SQLRARQNVIFELGFFVGKLGRGRVA.LL..R....KGDVEMLSDYHGVVYREHDD
B0UF11_METS4/156-275                 KVFIVHG...HDDAALQGLARFIEK.LG.LEAIVLKE.....QPDQG.RTIIEKFEQS...ATDVGYAVVLLTPD....DMGGA................KTTEE..QDTRARQNVIFELGYFAGRLGRGRVC.LL..K....KGRIEIPSDLFGVIYTEMDP
Q2K8S5_RHIEC/205-324                 KVFIVHG...HDEAALEKLARFLEK.VG.LEIIILKE.....QPNQG.RTIIEKYEGC...ADEVGFAVVLLTPD....DVGSA................AAATG..QAQRARQNVIFELGYFSGKLGRGKVC.LL..R....KGNVEMPSDLFGVVYTDMDS
B1ZZI8_OPITP/123-242                 .VFLVHG...HDEGAKHAVARFLEQ.LG.ITPVILQE.....QVNRG.MTVIEKFEEF...ASRAGFAVVLMTPD....DIGYA................ANHEGD.KKPRPRQNVILELGYFAAKLGRRRTL.VI..T....KGELEMPSDVFGLLYEPMDS
F0ZMV3_DICPU/57-185                  KVFIVHG...HNDEARQKVHNVLNG.LG.FEPIVLFE.....RANNG.DTIIEKLERE...VDQCSFGIVIVSPD....NIVYSKSK............DSQTYN..EMAYPRLNVIFEFGLLIGKLGRKNVI.FLNVPYTG.SNFYDLPSDLLGYVWINYDE
TIRC_DICDI/55-184                    KVFIVHG...HNNIVREKVSKFLFE.MG.FEPILLFE.....KPNNG.QTIIEKLEKE...ISNCKFGIVIMSPD....NKAFTKKD............SNSDYV..EIAYPRLNVVFEFGYLIGKFGRSNVI.YLSVPYNGKSQNYDLPSDLLGYVWINYTE
L0HBG8_METFS/245-360                 RVFISHG...KNKQIVDQLKEIIK..FGKYEPIISVE.....RESTS.KPVPDKVLDD...MRSCFAGVIIINNEGELIDQTGK.......................THKKINDNVLIEIGAALALYGRNNIL.LV.......QNGITLPSNLQGLYRCEY..
C4ZIE6_THASP/167-285                 .IFLGYCS..SSASTAAQIKRYLAS.QN.ASVLDWQS.....DFIPG.RTIIDQIEEA...ASRSIAGIFLFTKD....DDLANPS...................EAHQSVPRDNVVFEAGYFSGLKGKRNVL.IV......REAGSKMPADLGGDIYAALMD
Q027G3_SOLUE/4-122                   RIFIGSST..EGLPHACHIKELLTS.FGDIEPVLWTE......IFHPGLLTFEALENV...LLRCCAAVFVASAD....DVTTFRGQ....................CIHTPRANVMLEFGLVAGRIGRHSIALCL.......AGGAQLPSDLQGLTVIDMS.
R5R263_9FIRM/4-124                   RIFIGSSK..ESVKIAEKVKSLLD..GEY.VCQLWCD.....NFFDLGQCTYHELLKK...SLSFDYAIFIGGKD....DYVRRESD..................RTHKYAARDNVYLEFGLYAGILTYARCF.FL..IQEG....CQIASDLLGVNVVFFDK
C6W705_DYAFD/4-121                   RVFIGSSR..EGLPKAKLLKGYL...SGVADCQIWNE.....DFFENNKSSFESLSQS...STLFDFAILLASAD....DVVLKRDN....................LEISARDNVLFEFGLYVGRLGRNRAF.FV..KEKG....LNLPSDLYGITLSEFD.
B9TGA1_RICCO/4-125                   KIFIGSSR..EGLDIANAIHANLT..RD.AECTVWSN.....GVFQISGTTIYSLINA...LRNSDFGVFVFSPD....DLTIMRGQ....................QNPVVRDNVIFELGLFIGRLGVERCF.FI..TPDH.VADLRLPTDLMGIMPGQYEA
C5BHR5_TERTT/6-125                   .LFIASSS..ESLAIAEAVNVNLD..HE.FEITVWKN.....GTFKLSSSTIDDLVEK...SSFVDFALFIFAPD....DISEIRSR....................KEHVVRDNVIFEMGLFVGAIGKSRSF.IL..KPRG..IEMHLPTDLLGVTPADYDA
Q12JL6_SHEDO/5-125                   RVFIGSSV..ESLPIADAIAENLE..FD.AEVTIWRN.....GTFNLSSNALDDLISK...AKSVDFSIFIFSPD....DLTIMKSR....................EKYAVRDNVVFELGLFIGAIGKNRCF.IV..KPRD..VDLHFPSDLLGITPTDFDA
A5I3L4_CLOBH/140-260                 KIFIGSSK..EHLDVAYSLQEALE..YS.AEPTVWTQ.....GIFKLSSNTLDDLYNN...IKGMDAGIFIFTPD....DISDIREN....................SVSVVRDNVIFELGLAIGILGKQNVF.YI..IPRG..CDFHIPSDLAGITPGDYDA
Q7MKB6_VIBVY/8-129                   KLFIGSSV..EGLEVAYAIQSELE..HD.SEPTVWSQ.....GVFNLTQSTLSDLLSA...LDTFDAAIFVMSPD....DVVKMRGQ....................EQTVTRDNVLFELGMFIGRLGPEKTF.MV..KPRN.SQDFHVPTDLLGLTPGVYDN
Q8TKX7_METAC/9-127                   ..FIGSSK..EGLGIAQAIQLELE..EYA.TCTIWYQ.....GIFGLNEGTLESLEKS...LEKFEFAILVLTPD....DVVISRDK....................VVQLPRDNVLFELGLFMGRLGRKRVF.IV..YCDE..ENVKLPSDLAGVTVCRISK
C1F5N0_ACIC5/154-273                 RVFIISSA..EALDIARTIQNAFD..HDPFNVTVWTD.....GVFRASHYAIESLERA...LDQSDVAIAVAQPD....DITESRGQ....................QRATPRDNVIFELGFFMGRLGRHRAL.LV..EPRG..EEISLPSDLAGINTITY..
B1M988_METRJ/155-274                 .VFLFSSS..EALPVARAIENALA..DDPFLTVVWAN.....GVFKVTNYTLETLEEE...LMQSDFAVAVAHPD....DKTEIRDE....................EWPTPRDNVVFELGFFMGSLGRQRAV.LM..EPKG..AKLKLPSDLAGITTIKYN.
Q9A4X3_CAUVC/154-272                 RVFVISSV..EALPIARAIQTAFE..YDPFTVIVWTD.....GVFKVANYTLQSLEDE...IDNSDFAIAIAHPD....DKVESRQA....................QWPQPRDNVIFELGLFMGRLGRARAI.LM..EPRD..EKVKLPSDLAGVTTIG...
J9R4G8_RIEAN/5-130                   RIFIGSSS..EELDLASAAKSILEL.EKEFEVTIWNEDVWEKAVFRLNNSYLNDLIRA...TLQFDFGILIGTKD....DKVVYRGN....................EELQPRDNILFELGLFIGRLGLNNCA.FL..IDKD....IKLLSDIKGISLARFNR
D4LTG4_9FIRM/2-122                   RIFIASSG..ERLNMAIEVGSWLE..GMNVEPVLWNE....PEVFPLGAYTWDALIDL...SENVDAAIFIFGED....DQIWFRGE....................STMTVRDNVLLEYGLFSGKLSKANTI.FL......CDGRPKLASDLEGITWGDIRK
Q24ZU3_DESHY/13-134                  .IFLGSSSSQKAKDDMLKIAMLIE..EEGHTPFPWNK....EGLFPLGEYPAESLRNI...CQQVDAAILIFHED....DMTWYRNN....................YVLKPRDNVVYEYGLFEGHLGPKRTI.IC......RRGTPKLASDLEGITYCDLDK
K0AW63_CLOA9/134-254                 KIFLGSSK..EAEEVMDEIAVIIE..SYKHDALPWNQ....PGTFIAGNYLYDSLIDI...SKSVDAAIFIFNED....DEVWYRGD....................MLNQARDNVLIEYGLFTGALDRSKVI.FC......TKGNPKIASDLKGITYINMEM
D5C5H2_NITHN/120-239                 NVFVIHG...RDEAKWRELKDILRTEFR.LNPIILLE.....QPDAGCKTVIEKFEHY...AQTCSYAIAVFTPD....DEVTSGND....................KYLQARPNVIYELGWFCGRLGRSGAMLLL.......KEGTSLFSDFGGIIQKRFAK
I4BA92_TURPD/15-129                  KVFVSHG...RSPLWN.EVERFVRTQLE.IDVVILKD.....QVNRG.RTVIEKLEEE...TDECHYAIIVMTAE....DEQAD.......................GTIRARQNVVHEIGFFQGKFGRENVL.VL..R....QDSVEEFSNIAGIVYEPFSG
Q6AL85_DESPS/128-241                 .VFIGHG...GSSQWR.DLKDHLQDKHN.IKIEAYET.....GARAG.HTIRDILEDM...VNNSTFALLVMTAE....DEQDT.......................GQLRARQNVIHEIGLFQGRLGFNRAI.VL..M....ENSTEEFSNIAGVQQIRYSN
C1DBI6_LARHH/98-222                  QVFIVHG...HDDTAREQLELVLHK.LG.LDPYVLAN.....TGGHG.LTIIEALEAKIGKNAASSFGIVLMTPD....DMGYA................LSKGQDSAQPRARQNVVLEMGMLISSIGRRNIA.ILVK......GHLEKPSDADGILYIPFNN
E1W054_GLUAR/175-307                 RVFIVHG...RDLDSKNTLERFLKH.VD.ALPLTWTD..ARQLTNKPSPSTLEIVKAG...LMNAQAVVVLFTPD....DQARLDKQFVKPSDRSPEKE........LTGQARQNVILEAGMALAMDDQRTIL.VR.......KGFTRPISDIEGVHWIDLKD
F8B4J3_FRADG/196-328                 NVFVVHG...RDTGARDAMFAFLRA.VG.LRPIEWNE..AVRATGHPTPYIGEILTTA...FASAQAIVVLLTPD....DDARLAPAFWRPDDPPHERA........YTGQPRANVLFEAGMAMAVDARRTVL.VE.......VGRVRPFSDIAGRLVLHLNN
C7PYD3_CATAD/410-541                 .VFVIHG...RDERARVATFDLLRA.FG.LHPVEWDE..AVGLLQQPMPFLGRVLREA...IPRAKAVVVIMTPD....DIVRLHPELAGPSEPGFETG........HSMQARPNVLIELGMALAYHPRATLI.LQ.......VGDHRPIADLGGFNYVRVAE
V6KJV2_STRRC/56-188                  NVFVVHG...RDEEARLKVFDLLRL.LD.LRPLEWED..LVRATGKTAPFLGEVIAQA...PAQAQAALVLLTPD....DIVQLHPELRGPNEPPFESE........PTGQPRPNVLIELGMLLMAYPERTLL.VE.......IGTLRQISDIGGMNVIRFDG
Q9X882_STRCO/76-207                  .VFVVHG...RDDQVRREMYELLRR.LD.LRPKEWED..LVRATGQASPFLGDVVAGA...PAQAQAALVLLTPD....DVVTLHPELRGHNEPDHETR........PVCQPRPNVLIELGMVLMAYPERTLI.VE.......VGGVRPIADIAGRNVIRFDG
Q8XW61_RALSO/85-207                  KVFVVYG...HDNAARTELEAMLRR.WR.LEPLILDQ.....LPSEG.QTIIEKLEKY...TAEVKFAVVLATPD....DEGY.................RAGHEDEKAFRARQNVVMELGMMLTLLGRKNVA.ILMKQ....QDNMERPSDIQGLLYIPFKD
Q98RD6_MYCPU/91-212                  KVFIVHG...HDKIALLELKDLLRD.LK.LNVVISQN.....KTTRG.LSILDGVLED...ISSVSFAFDLLTPD....DKGYS................NLDGESKTLPRARQNVIFEMGMLYGKLPKNKIM.IL..N....KNDVELPSDINGMIYKSFKN
R6JZ57_9CLOT/29-145                  .IFIVHG...HDTLARIELKDYLQNTLGFPAPVILAE.....LPDCG.RTIIEKFEEQ...ADQADIVFVLLTPD....DFNHE.......................NQARARQNVIFELGYFIGKMGRKSGR.VILLS....KGNLDIPSDLSGILRIDIG.
#=GC seq_cons                        +VFIlHG...+spsstpplpchLct.hs.hcsllhp-.....tstpu.pollEclEpt...sspssaAlllhTPD....Dhstt.......................tphpsRpNVlFEhGhhhG+LGRpplh.hl.......psslchPSDltGlshhphsp
//