Summary: PhoPQ-activated pathogenicity-related protein
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PhoPQ-activated pathogenicity-related protein Provide feedback
Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria .
Garcia-Calderon CB, Casadesus J, Ramos-Morales F; , J Bacteriol. 2007; [Epub ahead of print]: Rcs and PhoPQ regulatory overlap in the control of Salmonella enterica virulence. PUBMED:17616593 EPMC:17616593
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR009199Proteins in this entry are believed to play a role in virulence/pathogenicity in Salmonella. Salmonella typhi PqaA has been shown to be activated by PhoP/Q two-component regulatory system, which regulates many virulence genes [PUBMED:9075219]. It has been also shown to confer resistance to antimicrobial peptides (melittin) [PUBMED:9075219]. Members of this family are predicted to belong to the alpha/beta hydrolase domain superfamily.
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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This catalytic domain is found in a very wide range of enzymes.
The clan contains the following 67 members:Abhydro_lipase Abhydrolase_1 Abhydrolase_2 Abhydrolase_3 Abhydrolase_4 Abhydrolase_5 Abhydrolase_6 Abhydrolase_7 Abhydrolase_8 Acyl_transf_2 Arb2 AXE1 BAAT_C Chlorophyllase Chlorophyllase2 COesterase Cutinase DLH DUF1057 DUF1100 DUF1350 DUF1400 DUF1749 DUF2048 DUF2235 DUF2305 DUF2424 DUF2920 DUF2974 DUF3089 DUF3141 DUF3530 DUF452 DUF676 DUF726 DUF818 DUF829 DUF900 DUF915 EHN Esterase Esterase_phd FSH1 Hydrolase_4 LCAT LIP Lipase Lipase_2 Lipase_3 Ndr PAF-AH_p_II Palm_thioest PE-PPE Peptidase_S10 Peptidase_S15 Peptidase_S28 Peptidase_S37 Peptidase_S9 PGAP1 PhaC_N PHB_depo_C PhoPQ_related Ser_hydrolase Tannase Thioesterase UPF0227 VirJ
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||COGs (COG4287)|
|Author:||COGs, Finn RD, Sammut SJ|
|Number in seed:||17|
|Number in full:||1070|
|Average length of the domain:||354.20 aa|
|Average identity of full alignment:||67 %|
|Average coverage of the sequence by the domain:||74.10 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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