# STOCKHOLM 1.0 #=GF ID CR6_interact #=GF AC PF10147.10 #=GF DE Growth arrest and DNA-damage-inducible proteins-interacting protein 1 #=GF AU Sammut SJ;0000-0003-4472-904X #=GF GA 29.4 29.4 #=GF NC 29.1 29.3 #=GF TC 29.7 30.2 #=GF SE KOGs (KOG4848) #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 12716909 #=GF RT CR6-interacting factor 1 interacts with Gadd45 family proteins #=GF RT and modulates the cell cycle. #=GF RA Chung HK, Yi YW, Jung NC, Kim D, Suh JM, Kim H, Park KC, Song #=GF RA JH, Kim DW, Hwang ES, Yoon SH, Bae YS, Kim JM, Bae I, Shong M; #=GF RL J Biol Chem. 2003;278:28079-28088. #=GF DR INTERPRO; IPR018472; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC Members of this family of proteins act as negative regulators of #=GF CC G1 to S cell cycle phase progression by inhibiting #=GF CC cyclin-dependent kinases. Inhibitory effects are additive with #=GF CC GADD45 proteins but occur also in the absence of GADD45 #=GF CC proteins. Furthermore, they act as a repressor of the orphan #=GF CC nuclear receptor NR4A1 by inhibiting AB domain-mediated #=GF CC transcriptional activity [1]. #=GF SQ 75 Q7QHT3.3/46-258 LPLTFVdddaestEAREARIAALRNKSRLLP..Q....HRN.MLH..GV..LP.Y....EQ.S...QSWI...........HD.T.VKYKRMMLGRYGIDgSKVDPR.VCFPTkKEAY.E.RA.EYE..R..V.A.FP.....FSLKQ.MMDANESERKARKAQIEAREA...EVA.............................RKLEKLDQWTADLNARIAK.......KEAEARAAK.ERKDRLVEE..VRRHFGFKVDPRDERFQEMLALKEREDR.KKVKEAKRKEKE.EKMMEKLQKKTA Q9VP13.1/29-231 LPASLVg.....dVDVEPTYPQTVDRSGLQP..Q....HKN.VLL..NK..LP.Y....QE.P...HSWI...........HL.T.EKYQRQAFGRYGAQ.SNVNPK.ICFDShGEK-.-.--.DSR..Q..V.M.QL.....ETLLK.MLEKNRAQKAEELARINAREE...DIA.............................KKMEKLTQWKADLHAKIAK.......READAAAAI.QRKERLVEE..VRRHFGFKVDTRDERFKEMLEQKEKEDK.KKQKEAKRKAKE.EKMMAKLVEKAS Q5XJW2.2/1-210 MAAP--.......ATRSRYLLRLT--VTLGP..R....SRS.YHA..PP..PP.R....RR.P...APHWpdrenlmtprwQL.T.PRYAAKQFGRHGAI.SGVPPA.SLWPS.SEQL.C.EL.EAE..E..R.E.WY.....PSLAT.MQESLRVQQQAAEARRQAREQ...HIA.............................ECMAKMPQMIENWRKQKRE.......RWEKIQADK.ERRARLQAE..AQEQLGYHVDPRSARFQELLQDLDKQQR.KRLKEERQRQKK.EARIAAMASAE- F1QAF2.1/19-237 MAASLL.......SRRTASSFSFTKLNSLLP..A....AVI.QIA..NY..NP.RplrlNL.K...DPYIpdkesertpewQK.T.EKFERRLFGRYGRA.SGVNPV.KLWPS.AARL.E.EL.MAE..E..R.E.WH.....PPVEQ.MLQNIAERQMEKEKRRIEREK...TIA.............................ESMAKMPKLIADWKKQKRE.......AKQKANEEK.QKQVRLLAM..ARERFGFAVDPRSVKFKEMVAEIEKEEK.KQRKLLKRQKKE.EEQTSITPTADS Q9CR59.1/6-211 ------.......-MRSGYLLRLS--VALGP..R....SRS.YRA..PP..PP.R....RR.P...GPHSpdpenlltprwQL.T.PRYVAKQFGRHGAI.SGVPPA.SLWPT.PEQL.R.EL.EAE..E..Q.E.WY.....PSLAT.MQESLRLQQQALEARRQAREQ...RIA.............................ECMAKMPQMIENWRKQKRE.......RWEKIQADK.ERRARLQAE..AQERLGYHVDPRSARFQELLQDLDKQQR.KRLKEERQRQKK.EARIAAMASAEA Q8TAE8.1/1-209 MAAS--.......VRQARSLLGVA--ATLAP..G....SRG.YRA..RP..PP.R....RR.P...GPRWpdpedlltprwQL.G.PRYAAKQFARYGAA.SGVVPG.SLWPS.PEQL.R.EL.EAE..E..R.E.WY.....PSLAT.MQESLRVKQLAEEQKRREREQ...HIA.............................ECMAKMPQMIVNWQQQQRE.......NWEKAQADK.ERRARLQAE..AQELLGYQVDPRSARFQELLQDLEKKER.KRLKEEKQKRKK.EARAAALAAA-- P90915.3/8-203 LVRSFA.......TNSSEEIAPKVDVSFLRP..R....HRI.IAA..GG..MP.P....VQ.F...DS--...........ER.E.RASRRERFGKYGLK.SGVPVE.ELFPT.----.-.--.-AE..E..I.E.EE.....EAIGL.FREFNNAKKEYKELQKKKRES...ELAria.......................eleKNLKKYPATLAKYEASLVK.......QEQEKDEKE.VALEKRIRD..IQEYFGYWMDPKDPRFEVMLQQKEAEEK.KAVKMAKRDEIQ.KKRFAENV---- A0A2J7QI39.1/69-264 ------.......ARKEEEIQRKRNKSRLNP..Q....HRN.LLH..EK..VP.Y....SE.P...MDWF...........HE.T.VKYKRKMYGRYGQS.SGVLPG.IMWPT.REEL.E.EMkEYE..S..V.A.YP.....YTIQE.LMTRAETKKKEEQEALKAREE...DIM.............................KKFAKLEQWKHEVKVNAAK.......KLAEVEAAK.AKKARLVEE..VRRHFGFKIDPRDDRFKELLEEKEKEER.KKAKDAKKKARQ.QLVMTRLKE--- R4FKS8.1/57-254 -----L.......EEKEAEIEAKRNKSMLRP..Q....HHN.ILH..GK..VP.Y....NE.P...VCDI...........HS.S.LRYKKRMFGRYGYE.SGVNPG.ALWPS.TEEIeE.RM.EYE..K..V.A.YP.....YTIPE.MWEKVRQRREEEEKTISERQA...KLA.............................YNVKKLDQWKKEIADRAAK.......KLQTAAAAK.AKKDALIEE..VRRHFGFKVDPRDEKFKEMLLQKERDQK.KKLKAERAKAKQ.EKLLSSLEKE-- A0A4C1T1Y0.1/43-239 ------.......-AREAEIQQKRNKSGLTK..A....HFN.LVN..GR..RP.Y....EV.P...KALA...........HL.T.VKYSRKMYGQYGSA.SGINPS.LCWPSmSDIQ.E.AK.EYE..T..V.A.FP.....YTIKE.MMEQVAKQREEKKLKILQRDA...EVA.............................AKFEKLEQWKKELNDKINK.......KCEETRAAK.EKKERLVEE..VRRHFGFKLDPRDERFQEMLAKREKEQK.KLEKQARKEARE.KQLIAKLQQKS- A0A1J1HKY3.1/61-254 ------.......--KKERIQAIRNKSRLND..N....HRR.LLL..GE..VP.Y....QN.A...QSWV...........HN.T.LKYKRKLYGKLGEK.SGLDPR.ICFWThTEIE.D.KN.EYE..R..T.A.YP.....KTVQE.MIQISEQDKKETKEKELKRDE...DIA.............................RNLEKLEMWKTDIVKRKEK.......RENDARVAK.ERKDRLIEE..VRRHFGYTIDIRDERFKQMLEEKQKQQR.KAMKESKRQEKE.SKLLEKLKS--- A0A1D2N747.1/122-317 ------.......-LTEEEIEAKRNISRLSI..Y....HQR.LVN..GQ..HP.Y....PE.P...MSWV...........HH.T.VRYKQKMFGQYGES.SGVNPG.ILWPT.HEELqN.KK.EFE..E..I.S.NP.....YTIQE.MVEIKLAQRKAEKEAVERRIK...FVE.............................ERMKLVDQFKEDLRKRLEA.......KEKESNEAK.ARKERLVEE..VRRHFGYTVDSRDERFQEMLAKKEKEDK.KKQKEARKLEKE.KRALEKLQGK-- A0A158NC23.1/56-250 ------.......--YQEELTKKRNKSRLSP..K....DRN.ILM..GK..PP.Y....EQ.P...IEWY...........HN.T.VRYKKRMLGRYGFE.GNKEPAgFAWPTpEEIK.I.LQ.EYE..R..V.A.FP.....ESLQD.RWKKLEEKKQIKAEKIKAREA...EIA.............................EKLSKVNQWTAELNARIAK.......KEAEMEAAK.LRKECIVEE..IRKHFGFKISPHDERFKTMLEQKEKEER.KKKKEAKKKAKE.EKLKSKIQK--- A0A482X7Z2.1/51-245 ------.......-QREEMIEMKRNVSRLQP..S....HRN.IVH..DQ..LP.Y....PE.P...QAKY...........HL.T.ERYRRRMYGRYGSA.SGVYPG.IMWPTvKDIE.E.RK.EYE..S..F.K.YP.....NTIQE.MVKNQVDEILDREDKINKRQE...QIK.............................ANMKKLEQWIKELHSKRAH.......KMKAALAER.EKKERLIEE..VRRHFGFTVDPREERFQEMMLKKEREER.RMAKEQRKQLRE.EKYLAELMS--- A0A226EJU1.1/1069-1263 ------.......--SEEEINQKRNKSRLRA..Y....HQR.LVN..GQ..VP.H....PE.P...VFWT...........HH.T.VEYKRRIFGKYGEA.SEVDPR.ILWPT.RKQL.KkKI.EYE..N..I.C.NP.....FTIQE.MITKTRKMKAAEEEAFEQRER...EVD.............................EKMKLVDKYKADLFAKQQA.......KDKEQKDAK.DRKEKLMEE..VRRHFGFTVDSRDERFQEMLAKKEKEQR.KAMKEAKKLEKQ.QKMLDKLEAE-- A0A139WMJ2.1/336-501 ------.......KAREEEIERKRNKSRLKN..S....DRN.ILF..DK..NP.Y....PE.P...EHWQ...........HG.T.LKYMRRTYGRYGEA.SGVDPS.ICWPV.KDEL.E.NAkEYE..R..V.A.FP.....YTITQ.IVEEAHKQRQEKNERIRLRQE...EIA.............................KKLEKLEQMKQDLYNRIRT.......KEKEATAAK.ERKERLIEE..VRMHFGYTVDPRDEKFKEL---------.------------.------------ C4WRY4.1/50-244 ------.......--SEGEVKAICDKSRLNH..G....HRN.MVN..GR..LP.Y....DK.P...VHRY...........HN.T.VKYKRRMYGRYGEA.SNVSPG.LAWPT.AEDL.A.DIrEYE..S..L.A.YP.....LTIQE.MQKNALELIESERQEIQTNQQ...RID.............................NNMKKLNGWLKEVKEKSAK.......KLLEAQQAK.EKKEKLIEE..VKKHFGYKIDPKDDRFKEMLVKREKEEK.KKVREEKKKIRE.EKLLNYLDSK-- W2SXV5.1/41-220 ------.......--------PRADISALKP..R....HRV.IAS..GG..MP.P....LE.F...E--W...........ER.Q.RNSQRERFGTYGLK.SGVEPS.ICWPT.VEEI.E.EE.Q--..A..I.G.LY.....REYET.CLREMKTLKQRNEAKDAARIA...ELE.............................RNLQKYPEVLAKYEASQVK.......AEKERDAKE.IALENRIRE..IQEYFGYWMDPKDPRFEVMLQQKEQEEK.KAAKMAKRAEIQ.KKKIAD------ A0A0N4WK66.1/21-197 ------.......------------CCSLKP..R....HRV.IAA..GG..MP.P....LE.F...E--W...........ER.K.RTAQRERFGTYGLK.SGVDPA.ICWPT.VEEI.E.EE.QA-..-..V.G.LY.....REYDL.CVREMNALKQKKEAKEAARIA...ELE.............................KNLQKYPEMLAKYEASQVK.......AEKERDEKE.IALENRIRE..IQEYFGYWMDPKDPRFEVMLQQKEQEEK.KAAKLAKKAEQQ.KKRIADV----- H9IV23.1/1-153 ------.......------------------..-....---.---..--..--.-....--.-...----...........--.-.------MYGKYGSA.SGVNPS.LCWPTrADIR.E.KL.EYE..S..E.A.YP.....FTIQE.MMETTRQKRLAEEEKILKRDQ...EIV.............................AKMAKLEMWKKELRNKVAK.......KTAEAQAAK.DKKERLVEE..VRRHFGFKLDSRDERFQEMLVKREKEQK.KQEKLARKEAKE.KVMIAKLQQKNA A0A2T7NPP5.1/5-196 ------.......-EEEEKIEALRDISGLRP..V....LKR.RIH..GQ..IP.E....IR.N...DY--...........QQ.T.LKYQRKLYAKFGKA.SGVDPR.IMWLT.KEEA.I.EQ.VEL..I..K.E.WE.....PSLEK.LLADLKAKKEADAKFIADREK...KIE.............................TNMAKMNQWIDEYKQRKKK.......KDEDIKAKE.AKKQKLIEE..AREFFGYYVDPRDTKFQEMVEEKERQEK.AKAKEIKKEKRK.EKLTARLQA--- A0A401NH51.1/55-208 ------.......------------------..-....---.---..--..--.-....--.-...-PEW...........QR.G.PRARRKLYGRWGGA.SGLQAE.ALWPE.PGEL.R.QL.RLH..Q..A.E.WE.....PSLQQ.MQSDLRARELEEQMQRRERQK...LIA.............................ANMAKMPKMVEDWRREKRE.......LKANQREEK.LRRERLLSE..ARERFGYTIDPRSAKFQEMVKELEKEEK.KKRKLMKRRQRE.EG---------- A0A2A2K0U8.1/17-196 ------.......---------HHHFCRLRP..R....HRI.LIE..GG..IP.P....VE.F...E--W...........EK.K.RTARRQRFGQFGLA.SGVNLE.ELWPT.VEEI.E.E-.-EE..A..I.G.MY.....RELQA.VLQEHKQLVAERKKAEAARDK...EIQ.............................ANIKKYPAILKKYEASQIK.......AEKEKDEKE.LTLERRIRE..IHEYFGYWLDPKDPRFGVMLQQKEAEEK.KAEKMAKRAEKE.KKKFADI----- A0A2A2KM47.1/58-233 ------.......-------------TRLRP..R....HRI.LIE..GG..IP.P....VE.F...E--W...........EK.K.RTARRQRFGQFGLA.SGVNLE.ELWPT.VEEI.E.E-.-EE..A..I.G.MY.....RELQA.VLQEHKQLVAERKKTEAARDK...EIQ.............................ANIKKYPAMLKKYEASQIK.......AEKEKDEKE.LTLERRIRE..IHEYFGYWLDPKDPRFGVMLQQKEAEEK.KAEKMAKRAEKE.KKKFADI----- A0A0R3PZ26.1/20-197 ------.......---------PVFHHRLKP..R....HRV.IAA..GG..MP.P....LE.F...DW--...........ER.E.RSAQRERFGTYGLK.SGINPS.ICWPT.VEEI.E.EE.QAVglY..R.E.YH.....TCLRD.MKAL----KGKQQEKEAARIA...ELD.............................KNLENYPNVLAKYEASLVK.......AEKERDAKE.IALENRIRE..IHEYFGYWMDPKDPRFEVMLQQKELEEK.KAAKLARRAEIQ.KKTIA------- A0A2A2K153.1/103-278 ------.......-------------TRLRP..R....HRI.LIE..GG..IP.P....VE.F...E--W...........EK.K.RTARRQRFGQFGLA.SGVNLE.ELWPT.VEEI.E.E-.-EE..A..I.G.MY.....RELQA.VLQEHKQLVAERKKAEAARDK...EIQ.............................ANIKKYPAILKKYEASQIK.......AEKEKDEKE.LTLERRIRE..IHEYFGYWLDPKDPRFGVMLQQKEAEEK.KAEKMAKRAEKE.KKKFADI----- C3YM53.1/45-223 ------.......------------------..-....---.--A..PP..FP.L....DR.S...-RYIpdksdpktpefQK.T.LKFDRKLWGRHGEA.SGFDPS.ICWPT.KAEL.A.EM.QEE..E..R.D.WC.....LTLQE.MQQNIAIRRAEEEKARIAREK...RIA.............................ANMAKMPKLIEQVHEERRL.......KKEQLEEAK.KRKEHLIAK..ARERLGYNVHPNSPKFEAMLEEIENEER.KQKKKAKKA-KQ.EAMREAFK---- A0A0N4XC52.1/28-200 ------.......----------------FP..R....HRI.IAA..GG..MP.P....VE.F...E--W...........ER.Q.RIAQRERFGTYGLK.SGISPS.ICWPT.VEEI.E.E-.--E..Q..A.MgLY.....REYDT.CLREMKALKQKAEAEEAARLA...ELE.............................RNLKKYPEALAKFEASQVK.......AEKERDAKE.IALENRIRE..IQEYFGYWMDPKDPRFEVMLQQKEQEEK.KAAKLAKRAEME.KKKIADI----- T1J5P6.1/51-247 ------.......----TEIDKLRNVSRMKP..H....LRK.ALL..RE..SM.Q...fKD.TlpyENWWv........tsYK.Q.KIIKAKYFGKYGVE.SGVEPG.ILWPN.REEL.E.KI.KAE..E..K.E.FY.....PSLQE.MMANVKKEKEEMAEKTRLRVL...EVD.............................EKMKKLDGWIKDLDMRKQK.......KLDDAKAQK.DKKEKLLEE..VRAHFGYVVDPQDEKFKELLAEKEKEEK.IAKKEAKKKEYI.AKELAKMQ---- A0A0L8GJT0.1/52-241 ------.......---TDELNQIRDVSRLSP..V....LKA.KLY..NE..FP.P....NF.G...ERES...........DN.K.KHYRRRIFAKFGSS.SNLDPA.SMWPS.KAEM.R.EL.IEE..Q..A.K.YE.....VPVHV.MLEKLRVERETEEEKVKLREQ...RIK.............................ENMKAMPKLIAEFHKQTEQ.......KQLLQKKQE.EKKAKLLEE..ARAYFGYSVDPRDEKFKQMLAEKEAAEK.KAAKQQKKAEKM.AKVTARL----- A0A0B2VC77.1/60-242 ------.......------L-LTKNISGLRA..R....HVA.LAE..GR..LA.P....VS.Y...E--W...........EK.E.RWAKRERFGRYGLA.SGVSVS.ELWPT.VEEV.Q.E-.-ES..A..L.G.LY.....TSYSE.ALKRSQIAQEKAKTAISARLE...KLA.............................KNEANYATVLAKFEASNVK.......AEKEKSEKE.EKLERRIRE..IQEYFGYWIDPKDPRFEVMLAQKEADEK.KAEKLARRQAAE.KKKIAAVV---- A0A3S3RPR9.1/28-223 ------.......--TDDEIMAIRDKSGLSP..Q....LKA.IKN..SE..LS.K....PE.R...FQYL...........HQyR.ENNVRRYYAKYGKK.SGLKPG.VMWPS.KAKF.E.FI.KQF..E..A.T.FY.....PSLEK.LWADAKAEKEAAEKEIRQREA...EIA.............................ANLKKLPQLKKEFFAKLES.......KRLEAEAER.TKKEKLIQD..IREYLGYDVDPGDIRFQEALLKKEEEDK.LKAKAEKKISKQ.AKLLAKIAEMT- E9HK90.1/58-243 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-----L.......NESSERTPRYTNVSGLKPhlR....ARM.KHV..NE..IP.D...pTV.A...HNVA...........QL.R.PRYRAKLYAKHGAA.SGVDPG.VMWPS.KEEL.A.EI.KDI..E..A.E.FK.....PTLQE.LWANVAEKRESEKAARLAKEA...TVA.............................RSMAAMPKYIQEHKARLLK.......TEAEEAAAL.AKQKELMEE..ARDYYGYEIARNDPRFVLMVEMKEEEAK.AAKKQKKKEDRD.------------ A0A0N5AU23.1/11-171 ------.......------------CFGLNE..R....HRL.IAE..GK..IP.L....VT.Y...E--W...........EK.E.KWGKRMRFGKYGLA.SGVSPS.DLWPT.VEEV.E.--.EEE..S..F.H.LY.....RPFSE.VMKEVKSSAEKRKSMLQRRME...ELA.............................KNESNYENRLKQYEASLVK.......VEEKKSEAE.AKMEKRILE..IQEYFGYRIDPKDPRFEVMFQQKEAEEK.KAT---------.------------ A0A087TGE1.1/58-248 ------.......---EEEIQRKRFKSRLPE..R....VYR.IFV..QKeaVP.I....EA.K...Y---...........DF.T.MKRLQSYYARHGKD.SKLNPG.ICWPT.KEEI.L.ET.IKY..D..K.I.FE.....PPLQE.LMKKVEVARSAEEKRKKEVEA...EVD.............................RNMANLDKWMAEYYAKIEK.......KEQQAIELK.QKREQQIDA..VSEYLGYEINPKDPRFQEAVEQMKKDEK.KALKVKKQKESY.DKMIAKLKE--- A0A2C9LVE8.1/48-231 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