Summary: Latarcin precursor
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This family represents the precursor proteins for a number of short antimicrobial peptides called Latarcins. Latarcins were discovered in the venom of the spider Lachesana tarabaevi . Latarcins are likely to adopt amphipathic alpha-helical structure in the plasma membrane.
Kozlov SA, Vassilevski AA, Feofanov AV, Surovoy AY, Karpunin DV, Grishin EV; , J Biol Chem. 2006;281:20983-20992.: Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. PUBMED:16735513 EPMC:16735513
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018802
This entry represents the precursor proteins for a number of short antimicrobial peptides called Latarcins. Latarcins were discovered in the venom of the spider Lachesana tarabaevi [PUBMED:16735513]. Latarcins are likely to adopt amphipathic alpha-helical structure in the plasma membrane.
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EGFdomains, and finally a single
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Curation and family details
|Seed source:||Bateman A|
|Number in seed:||7|
|Number in full:||14|
|Average length of the domain:||66.10 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||75.41 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Latarcin domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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