Summary: Virulence protein nec1
Virulence protein nec1 Provide feedback
This is a family of virulence proteins that are found in pathogenic Streptomyces species.
Bukhalid RA, Chung SY, Loria R; , Mol Plant Microbe Interact. 1998;11:960-967.: nec1, a gene conferring a necrogenic phenotype, is conserved in plant-pathogenic Streptomyces spp. and linked to a transposase pseudogene. PUBMED:9768513 EPMC:9768513
Bukhalid RA, Takeuchi T, Labeda D, Loria R; , Appl Environ Microbiol. 2002;68:738-744.: Horizontal transfer of the plant virulence gene, nec1, and flanking sequences among genetically distinct Streptomyces strains in the Diastatochromogenes cluster. PUBMED:11823214 EPMC:11823214
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This tab holds annotation information from the InterPro database.
InterPro entry IPR018836
The Nec1 protein has necrogenic activity on excised potato tuber tissue, and the encoding gene is highly conserved in plant-pathogenic Streptomyces spp. The G+C content of nec1 indicates lateral transfer from an unrelated taxon, but its origins are unclear. Deletion analysis of nec1 demonstrated that the 151-amino-acid C-terminal region of the Nec1 protein is sufficient to confer necrogenic activity. Streptomyces turgidiscabies containing a nec1 deletion was greatly compromised in virulence on Arabidopsis thaliana (Mouse-ear cress), Nicotiana tabacum (Common tobacco), and Raphanus sativus (Radish) seedlings. The wild-type strain, S. turgidiscabies Car8, aggressively colonized and infected the root meristem of radish, whereas the delta-nec1 mutant Car811 did not. Taken together, the data suggest that Nec1 is a secreted virulence protein with a conserved plant cell target that acts early in plant infection [PUBMED:17555268].
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Curation and family details
|Seed source:||Pfam-B_11405 (release 21.0)|
|Author:||Mistry J, Morningstar A|
|Number in seed:||1|
|Number in full:||23|
|Average length of the domain:||167.20 aa|
|Average identity of full alignment:||92 %|
|Average coverage of the sequence by the domain:||85.05 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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