Summary: Golgi transport complex subunit 5
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The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.
Fotso P, Koryakina Y, Pavliv O, Tsiomenko AB, Lupashin VV; , J Biol Chem. 2005;280:27613-27623.: Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. PUBMED:15932880 EPMC:15932880
Internal database links
|Similarity to PfamA using HHSearch:||COG2 Vps51|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019465
The conserved oligomeric Golgi (COG) complex is a peripheral membrane complex involved in intra-Golgi protein trafficking. Subunit 5 is located in the smaller, B lobe, together with subunits 6-8, and has been shown to bind subunits 1 and 7 [PUBMED:15932880].
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This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
The clan contains the following 16 members:COG2 COG5 COG6 Dor1 DUF2450 Exo70 Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Zw10
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Curation and family details
|Seed source:||Pfam-B_24958 (release 21.0)|
|Author:||Wood V, Coggill PC|
|Number in seed:||16|
|Number in full:||280|
|Average length of the domain:||126.10 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||20.85 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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