Summary: Golgi transport complex subunit 5
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Golgi transport complex subunit 5 Provide feedback
The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.
Fotso P, Koryakina Y, Pavliv O, Tsiomenko AB, Lupashin VV; , J Biol Chem. 2005;280:27613-27623.: Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex. PUBMED:15932880 EPMC:15932880
Internal database links
|SCOOP:||Chlorosome_CsmC DUF3138 AKNA Collagen_mid UPF0693 SesA|
|Similarity to PfamA using HHSearch:||COG2 Vps51|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019465
The conserved oligomeric Golgi (COG) complex is a peripheral membrane complex involved in intra-Golgi protein trafficking. Subunit 5 is located in the smaller, B lobe, together with subunits 6-8, and has been shown to bind subunits 1 and 7 [PUBMED:15932880].
Defects in COG5 are the cause of congenital disorder of glycosylation type 2I (CDG2I). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterised by under-glycosylated serum glycoproteins [PUBMED:19690088].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||Golgi transport complex (GO:0017119)|
|Biological process||intra-Golgi vesicle-mediated transport (GO:0006891)|
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This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
The clan contains the following 17 members:COG2 COG5 COG6 Dor1 DUF2450 Exo70 Exo84_C Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Zw10
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Curation and family details
|Seed source:||Pfam-B_24958 (release 21.0)|
|Author:||Wood V, Coggill PC|
|Number in seed:||16|
|Number in full:||503|
|Average length of the domain:||127.20 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||20.95 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the COG5 domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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